Regeneration of Invitro Plantlets in Hemidesmus indicus (L.) R. Br. through Nodal and Leaf Explants

Invitro plantlet regeneration of Hemidesmus indicus (L.) R.Br, through nodal and leaf explants were attempted by culturing on MS medium supplemented with various PGRs. Nodal and leaf explants induced callus on media containing 2,4-D, 2,4,5-T, 2ip, IAA, NAA, BAP and KIN. The highest frequency of callus was observed in the leaf explants supplemented with 1.0, 3.0, 5.0 mgL-1 concentration of IAA, NAA, IBA. Rhizogenesis was observed in leaf explants highly in Auxin treatment like 2,4-D and 2,4,5-T with the concentrations of 0.2 mgL-1 and 0.5 mgL-1 respectively. Shoot differentiation was obtained from the callus of nodal explants on MS-medium with 1.0, 3.0, 5.0 mgL-1 of 2,4,5-T, KIN and BAP. Regenerated shoots showed rhizogenesis in MS-medium supplemented with 0.5 mgL-1 of IBA and KIN. Eight week old rooted invitro plantlets of H.indicus were removed from the culture vessels and transplanted into plastic pots. The plantlets were exposed to a relative humidity of 80%-90% and temperature 28±2ºC during day time, and 24 ±2ºC during night time. The percentage of surviving plantlets were recorded after four weeks of acclimatization. More than 95% of acclimatized plantlets grew vigorously without any morphological abnormalities

EFFECTIVENESS OF LOW-COST CUSTOMIZED SADDLE PILLOW ON PAIN IN POST-EPISIOTOMY PATIENTS

Objective: To examine the effectiveness of customized saddle pillow for pain in post-episiotomy patients and also to analyze the duration of sitting for breastfeeding and other functional activities following episiotomy.Methods: A total of 28 postnatal mothers who have undergone episiotomy were included in the study based on the inclusion criteria and were divided conveniently into an experimental group (n=16) and control group (n=12). Both the groups received the conventional physiotherapy protocol, but experimental group patients, in addition, were provided with customized saddle pillow. Customized saddle pillow was used by the patients from postnatal day (PND) 0 to PND 2. Pre- and post-test values for pain were assessed through the numerical pain rating scale (NPRS). In addition, data such as duration of sitting for breastfeeding and other functional activities were collected through sitting tracker.Results: The study manifested the effectiveness of low-cost customized saddle pillow in reducing perineal pain (p=0.01) and increase in sitting duration (p=0.01) in post-episiotomy patients compared to the control group.Conclusion: Among the postnatal mothers selected for the study the mothers who used customized saddle pillow experienced a reduction in pain as well as the better sitting duration for breastfeeding. The research recommends mothers who underwent episiotomy to use the low-cost saddle pillows for healthier breastfeeding and pain-free life

Farmakološko djelovanje izatina i njegovih derivata

Isatin is an endogenous compound identified in humans that possesses wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activity and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin N-Mannich bases of isatin-3-thiosemicarbazones have shown antiviral and tuberculostatic activity. Methisazone is an effective compound against variola and vaccinia viruses. The N-dimethyl and morpholino derivative of 5-methyl isatin and trimethoprim exhibited an EC50 of more than 4.3 and 17.7 microgram mL-1 and 17.7 microgram mL-1, respectively. Isatin (3-o-nitrophenyl)hydrazone has shown activity against Walker carcinoma-256. Various substituted indolinones showed antitubercular activity against M. tuberculosis H37Rv with MIC ranging from 10-20 microgram mL-1. Isatin derivatives of Mannich bases had fibrinolytic, muscle relaxant, antiallergic, immunosuppressant, and antithrombotic activity. Isatin showed cardioinhibitory effect on frog heart, and hypotensive, respiratory depression and antidiuretic effects.Izatin je endogeni spoj prisutan u organizmu čovjeka koji posjeduje niz farmakoloških učinaka. Izatin djeluje kao antioksidans, sedativ i antikonvulziv. In vitro je snažni antagonist na receptorima za natrijeve ione u atriju. Serija p-supstituiranih semikarbazona izatina pokazala je antikonvulzivno djelovanje u MES, scPTZ i scSTY testovima, a N-Mannichove baze izatina i izatin-3-tiosemikarbazona virustatsko i tuberkulostatsko djelovanje. Metisazon je učinkovit protiv infekcija variola i vakcinia virusima. EC50 N-dimetil i morfolino derivata 5-metilizatina i trimetoprima veći je od 4,3, odnosno 17,7 g mL-1. Izatin (3-o-nitrofenilhidrazon) inhibira rast tumorskih stanica Walker-256, a supstituirani indolinoni su aktivni protiv M. tuberculosis H37Rv (MIC vrijednosti 1020 g mL-1. Mannichove baze izatina djeluju kao fibrinolitici, miorelaksansi, antihistaminici, imunosupresivi i antitrombotici. Izatin ima kardioinhibitorni učinak na srce žabe, a djeluje i kao hipotenziv, depresor respiracije i antidiuretik

Farmakološko djelovanje izatina i njegovih derivata

Isatin is an endogenous compound identified in humans that possesses wide range of biological activities. Isatin has anxiogenic, sedative, anticonvulsant activity and acts as a potent antagonist on atrial natriuretic peptide receptors in vitro. A series of p-substituted isatin semicarbazones have shown anticonvulsant activity in MES, scPTZ and scSTY tests. Various isatin N-Mannich bases of isatin-3-thiosemicarbazones have shown antiviral and tuberculostatic activity. Methisazone is an effective compound against variola and vaccinia viruses. The N-dimethyl and morpholino derivative of 5-methyl isatin and trimethoprim exhibited an EC50 of more than 4.3 and 17.7 microgram mL-1 and 17.7 microgram mL-1, respectively. Isatin (3-o-nitrophenyl)hydrazone has shown activity against Walker carcinoma-256. Various substituted indolinones showed antitubercular activity against M. tuberculosis H37Rv with MIC ranging from 10-20 microgram mL-1. Isatin derivatives of Mannich bases had fibrinolytic, muscle relaxant, antiallergic, immunosuppressant, and antithrombotic activity. Isatin showed cardioinhibitory effect on frog heart, and hypotensive, respiratory depression and antidiuretic effects.Izatin je endogeni spoj prisutan u organizmu čovjeka koji posjeduje niz farmakoloških učinaka. Izatin djeluje kao antioksidans, sedativ i antikonvulziv. In vitro je snažni antagonist na receptorima za natrijeve ione u atriju. Serija p-supstituiranih semikarbazona izatina pokazala je antikonvulzivno djelovanje u MES, scPTZ i scSTY testovima, a N-Mannichove baze izatina i izatin-3-tiosemikarbazona virustatsko i tuberkulostatsko djelovanje. Metisazon je učinkovit protiv infekcija variola i vakcinia virusima. EC50 N-dimetil i morfolino derivata 5-metilizatina i trimetoprima veći je od 4,3, odnosno 17,7 g mL-1. Izatin (3-o-nitrofenilhidrazon) inhibira rast tumorskih stanica Walker-256, a supstituirani indolinoni su aktivni protiv M. tuberculosis H37Rv (MIC vrijednosti 1020 g mL-1. Mannichove baze izatina djeluju kao fibrinolitici, miorelaksansi, antihistaminici, imunosupresivi i antitrombotici. Izatin ima kardioinhibitorni učinak na srce žabe, a djeluje i kao hipotenziv, depresor respiracije i antidiuretik

Stochastic optimization of electricity transmission : dynamic programming algorithms under uncertainties

Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.Includes bibliographical references (leaves 141-144).by Ishwar Krishnan Ashok Sivakumar.M.Eng

Sparrow Search Algorithm based BGRNN Model for Animal Healthcare Monitoring in Smart IoT

Rural regions rely heavily on agriculture for their economic survival. Therefore, it is crucial for farmers to implement effective and technical solutions to raise production, lessen the impact of issues associated to animal husbandry, and improve agricultural yields. Because of technological developments in computers and data storage, huge volumes of information are now available. The difficulty of extracting useful information from this mountain of data has prompted the development of novel approaches and tools, such as data mining, that can help close the informational gap. To evaluate data mining methods and put them to use in the Animal database to create meaningful connections was the goal of the suggested system. The study's primary objective was to develop an IoT-based Integrated Animal Health Care System. Various sensors were used as the research tool to collect physical and environmental data on the animals and their habitats. Temperature, heart rate, and air quality readings were the types of information collected. This research contributes to the field of health monitoring by introducing an Optimised Bidirectional Gated Recurrent Neural Network approach. The BiGRNN is an improved form of the Gated Recurrent Unit (GRU) in which input is sent both forward and backward through a network and the resulting outputs are connected to the same output layer. Since the BiGRNN method employs a number of hyper-parameters, it is optimised by means of the Sparrow Search Algorithm (SSA). The originality of the study is demonstrated by the development of an SSA technique for hyperparameter optimisation of the BiGRNN, with a focus on health forecasting. Hyperparameters like momentum, learning rate, and weight decay may all be adjusted with the SSA method. In conclusion, the results demonstrate that the suggested tactic is more effective than the current methods

Analysis of voluntary reported adverse drug reactions in a tertiary care hospital

Background: Adverse drug reactions are the major cause for increased hospital stay and it increases the economic burden of the patients. Reporting of ADR helps in signal generation and to ensure safe use of a drug. Present study was conducted to analyse the ADR reporting pattern and completeness of the ADR forms. Methods: This was a retrospective study conducted for 6 months in a tertiary care hospital. A total of 330 ADR forms were analysed and completeness of ADR forms were assessed. Results: A total of 330 ADRs were reported. 46% ADRs were reported in 2018, 23% in 2019, 11% in 2020, 8.9% in 2021 and 10.7% in 2022. 177 (53%) were males and 153 (47%) were females. Most occurred reaction was Hyponatremia 22 (6%), followed by Hypokalaemia 18 (5%). Neuropsychiatry cases were 62 (18.78%), Urinary system cases were 45 (13.63%). 122 (88%) patients were taking concomitant drugs whereas only 17 (12%) patients were not taking. Above 80% completeness were seen in 155 (46.96%) forms. Above 70% completeness in 292 (88.68%) forms. Conclusions: ADRs occurrence was high in male compared to female. Most of the ADRs affected Neuropsychiatry followed by Urinary system. Antimicrobials are responsible for majorly reported ADRs followed by cephalosporins (17.6%) and Penicillin (11.76%). Overall completeness of reported ADR form was 80%, 67.87% of forms were not adequately filled with mandatory fields.