509 research outputs found
Time step rescaling recovers continuous-time dynamical properties for discrete-time Langevin integration of nonequilibrium systems
When simulating molecular systems using deterministic equations of motion
(e.g., Newtonian dynamics), such equations are generally numerically integrated
according to a well-developed set of algorithms that share commonly agreed-upon
desirable properties. However, for stochastic equations of motion (e.g.,
Langevin dynamics), there is still broad disagreement over which integration
algorithms are most appropriate. While multiple desiderata have been proposed
throughout the literature, consensus on which criteria are important is absent,
and no published integration scheme satisfies all desiderata simultaneously.
Additional nontrivial complications stem from simulating systems driven out of
equilibrium using existing stochastic integration schemes in conjunction with
recently-developed nonequilibrium fluctuation theorems. Here, we examine a
family of discrete time integration schemes for Langevin dynamics, assessing
how each member satisfies a variety of desiderata that have been enumerated in
prior efforts to construct suitable Langevin integrators. We show that the
incorporation of a novel time step rescaling in the deterministic updates of
position and velocity can correct a number of dynamical defects in these
integrators. Finally, we identify a particular splitting that has essentially
universally appropriate properties for the simulation of Langevin dynamics for
molecular systems in equilibrium, nonequilibrium, and path sampling contexts.Comment: 15 pages, 2 figures, and 2 table
Near-equilibrium measurements of nonequilibrium free energy
A central endeavor of thermodynamics is the measurement of free energy
changes. Regrettably, although we can measure the free energy of a system in
thermodynamic equilibrium, typically all we can say about the free energy of a
non-equilibrium ensemble is that it is larger than that of the same system at
equilibrium. Herein, we derive a formally exact expression for the probability
distribution of a driven system, which involves path ensemble averages of the
work over trajectories of the time-reversed system. From this we find a simple
near-equilibrium approximation for the free energy in terms of an excess mean
time-reversed work, which can be experimentally measured on real systems. With
analysis and computer simulation, we demonstrate the accuracy of our
approximations for several simple models.Comment: 5 pages, 3 figure
On the Solution of a Computable General Equilibrium Model
Many of today's most significant socioeconomic problems, such as slower economic growth, the decline of some established industries, and shifts in patterns of foreign trade, are international or transnational in nature. But these problems manifest themselves in a variety of ways; both the intensities and the perceptions of the problems differ from one country to another, so that intercountry comparative analyses of recent historical developments are necessary. Through these analyses we attempt to identify the underlying processes of economic structural change and formulate useful hypotheses concerning future developments. The understanding of these processes and future prospects provides the focus for IIASA's project on Comparative Analysis of Economic Structure and Growth.
Our research concentrates primarily on the empirical analysis of interregional and intertemporal economic structural change, on the sources of and constraints on economic growth, on problems of adaptation to sudden changes, and especially on problems arising from changing patterns of international trade, resource availability, and technology. The project relies on IIASA's accumulated expertise in related fields and, in particular, on the data bases and systems of models that have been developed in the recent past.
This paper is concerned with the solution algorithm of a nonlinear multisectoral model. The model has been developed at IIASA and falls into the class of so called computable general equilibrium models. The economic theoretical properties of the model, as well as some results of simulations based on it, have been reported elsewhere
Thermodynamic metrics and optimal paths
A fundamental problem in modern thermodynamics is how a molecular-scale
machine performs useful work, while operating away from thermal equilibrium
without excessive dissipation. To this end, we derive a friction tensor that
induces a Riemannian manifold on the space of thermodynamic states. Within the
linear-response regime, this metric structure controls the dissipation of
finite-time transformations, and bestows optimal protocols with many useful
properties. We discuss the connection to the existing thermodynamic length
formalism, and demonstrate the utility of this metric by solving for optimal
control parameter protocols in a simple nonequilibrium model.Comment: 5 page
Nonequilibrium Energy Transduction in Stochastic Strongly Coupled Rotary Motors
Living systems at the molecular scale are composed of many constituents with
strong and heterogeneous interactions, operating far from equilibrium, and
subject to strong fluctuations. These conditions pose significant challenges to
efficient, precise, and rapid free energy transduction, yet nature has evolved
numerous molecular machines that do just this. Using a simple model of the
ingenious rotary machine FoF1-ATP synthase, we investigate the interplay
between nonequilibrium driving forces, thermal fluctuations, and interactions
between strongly coupled subsystems. This model reveals design principles for
effective free energy transduction. Most notably, while tight coupling is
intuitively appealing, we find that output power is maximized at
intermediate-strength coupling, which permits lubrication by stochastic
fluctuations with only minimal slippage.Comment: 17 pages, 12 figures. J. Phys. Chem. Lett., 202
The thermodynamics of prediction
A system responding to a stochastic driving signal can be interpreted as
computing, by means of its dynamics, an implicit model of the environmental
variables. The system's state retains information about past environmental
fluctuations, and a fraction of this information is predictive of future ones.
The remaining nonpredictive information reflects model complexity that does not
improve predictive power, and thus represents the ineffectiveness of the model.
We expose the fundamental equivalence between this model inefficiency and
thermodynamic inefficiency, measured by dissipation. Our results hold
arbitrarily far from thermodynamic equilibrium and are applicable to a wide
range of systems, including biomolecular machines. They highlight a profound
connection between the effective use of information and efficient thermodynamic
operation: any system constructed to keep memory about its environment and to
operate with maximal energetic efficiency has to be predictive.Comment: 5 pages, 1 figur
The geometry of thermodynamic control
A deeper understanding of nonequilibrium phenomena is needed to reveal the
principles governing natural and synthetic molecular machines. Recent work has
shown that when a thermodynamic system is driven from equilibrium then, in the
linear response regime, the space of controllable parameters has a Riemannian
geometry induced by a generalized friction tensor. We exploit this geometric
insight to construct closed-form expressions for minimal-dissipation protocols
for a particle diffusing in a one dimensional harmonic potential, where the
spring constant, inverse temperature, and trap location are adjusted
simultaneously. These optimal protocols are geodesics on the Riemannian
manifold, and reveal that this simple model has a surprisingly rich geometry.
We test these optimal protocols via a numerical implementation of the
Fokker-Planck equation and demonstrate that the friction tensor arises
naturally from a first order expansion in temporal derivatives of the control
parameters, without appealing directly to linear response theory
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