N-(3-Chloro­propion­yl)-N′-phenyl­thio­urea

The title compound, C10H11ClN2OS, adopts a cis-trans configuration with respect to the position of the phenyl and 3-chloro­propionyl groups relative to the thiono group across the C—N bonds. The benzene ring is perpendicular to the propionyl thio­urea fragment with a dihedral angle of 82.62 (10)°. An intra­molecular N—H⋯O inter­action occurs. The crystal structure is stabilized by inter­molecular N—H⋯S hydrogen bonds, which link pairs of mol­ecules, building up R 2 2(8) ring motifs, and C—H.. π inter­actions

N-(2-Chloro-5-nitrophenyl)-N′-(3-chloropropionyl)thiourea

The title compound, C10H9Cl2N3O3S, adopts a trans–cis conformation with respect to the position of chloropropionyl and chloronitrobenzene groups respectively, against the thiono about their C—N bonds. The conformation is stabilized by an intramolecular N—H...O hydrogen bond. In the crystal, there is a short Cl...Cl contact with a distance of 3.386 (13) Å

Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities

Abstract Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as statins for hypercholesterolemia or beta-blockers for hypertension, the elderly appear to present a greater likelihood of suffering non-related side effects such as increased risk of developing new onset type 2 diabetes (NODM). In some cases, lower efficacy in the elderly have also been reported. Alternative forms of treatment have been sought to address these issues, and there has been a growing interest in looking at herbal remedies or plant-based natural compounds. Oxidative stress and inflammation are implicated in the manifestation of ageing-related cardiovascular disease. Thus, it is natural that a compound that possesses both antioxidative and anti-inflammatory bioactivities would be considered. This review article examines the potential of tocotrienols, a class of Vitamin E compounds with proven superior antioxidative and anti-inflammatory activity compared to tocopherols (the other class of Vitamin E compounds), in ameliorating ageing-related cardiovascular diseases and its associated morbidities. In particular, the potential of tocotrienols in improving inflammaging, dyslipidemia and mitochondrial dysfunction in ageing-related cardiovascular diseases are discussed

The value of open-source clinical science in pandemic response: lessons from ISARIC

International audienc