MP-6 Coccidiosis Intestinal Dysmotility in C57BL/6 Mice

Recently, anecdotal report was arisen that coccidiosis in cattle resulted in delayed intestinal motility. The occurrence of delayed intestinal motility has been never briefly reported. However, some study indicated a delay in intestinal motility. A study in cattle coccidiosis reported a transient increase of nutrients apparent digestibility, especially of crude fiber index, during clinical coccidiosis and that anorexia and intestinal leakage impaired the nitrogen balance, causing weight depression. The observation may have reflected intestinal hypomotility, however, this work did not observe the intestinal motility directly. Another study indicated that Eimeria infection in rabbit could induce intestinal motility disturbance. The disturbance, however, did not indicate as general delay in intestinal transit, because some part of the intestine experienced faster motility and another part indicated slower motility.As one of the cosmopolitan diseases of production animal, the occurrence of intestinal dysmotility by coccidiosis need to be clarified. And a control measure against intestinal dysmotility of coccidiosis need to be proposed soon after the clarification of its clinical existence. Therefore, we designed a study with murine Eimeria as model to provide evidence for better approach toward this emerging issue

MP-11 Eimeria pragensis Induce Immune Mediated Intestinal Hypomotility in C57BL/6 Mice

The manifestation of intestinal dysmotility of coccidiosis has never been briefly reported before. From murine Eimeria study we concluded that Eimeria pragensis (Ep) is capable to induce intestinal hypomotility described to be similar to pan-enteric ileus.In comparison with the intestinal dysmotility in postoperative ileus which is orchestrated by TH1 immune response [1], a local injury to some part of intestine could trigger pan-enteric ileus. If the TH1 immune response could also be induced in Ep infection, the delay in intestinal motility could be explained as similar mechanism as the post-operative ileus. Since the Ep infestation occurred in the ileocecal part of the intestines, with similar mechanism of post-operative ileus, the pan-enteric ileus could be triggered. In this study, we tried to find a relationship between intestinal dysmotility and TH1 immune response in murine coccidiosis