Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk

Psychological reactions of family members of patients in intensive care unit in Iran

Studies suggest that family members of patients in the icu and true negative changes in your life as stress, physical, emotional - psychological and social experience Members stress has increased over time, eventually resulting in impaired function and role of the family. This alone can cause severe fouling in distress within the family system. Therefore, this study compared stress, anxiety and depression in family members of patients hospitalized in intensive ccu, icu in Iran. This descriptive - analytical comparison. On 200 first-degree family members of the patients admitted to the ICU ccu, icu hospital Anbiya paced Zahedan in 2014. Stress and depression DASS questionnaire collected data using spss software and parametric t-test and chi-square test was used for statistical analysis. Our findings in the study of stress, anxiety and depression in family members of ICU patients in ICU, CCU showed. ICU hospitalized patients, family stress, anxiety and depression in family members of patients with more than hospitalized in CCU experience. When a patient is admitted in intensive care unit patients and family members should be treated with respect and make a decision that impacts the physiological and psychological symptoms in family members. Members often stress, anxiety and depression so it seems the nurses support patients and families through health communication proper and assist them in the discharge of feelings and emotions, to create hope in families and reduce their stress levels