Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS

Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome

Lynch syndrome (LS) increases cancer risk. There is considerable individual variation in LS cancer occurrence, which may be moderated by lifestyle factors, such as body weight and physical activity (PA). The potential associations of lifestyle and cancer risk in LS are understudied. We conducted a retrospective study with cancer register data to investigate associations between body weight, PA, and cancer risk among Finnish LS carriers. The participants (n = 465, 54% women) self-reported their adulthood body weight and PA at 10-year intervals. Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased risk of all cancers (HR 1.02, 95% CI 1.00–1.04) and CRC (HR 1.03, 1.01–1.05) in men. The near-term weight change was associated with a lower CRC risk in women (HR 0.96, 0.92–0.99). Furthermore, 77.6% of the participants retained their PA category over time. Men in the high-activity group had a reduced longitudinal cancer risk of 63% (HR 0.37, 0.15–0.98) compared to men in the low-activity group. PA in adulthood was not associated with cancer risk among women. These results emphasize the role of weight maintenance and high-intensity PA throughout the lifespan in cancer prevention, particularly in men with LS

Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning

The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function and body composition. Two independent cohorts (N = 139 and N = 47) were included, whose age span covered adulthood (23–69 years). Whole blood and m. vastus lateralis samples were collected, and DNA methylation was analysed. Four different DNA methylation age (DNAmAge) estimates were calculated using genome-wide methylation data and publicly available online tools. A novel muscle-specific methylation age was estimated using the R-package ‘MEAT’. PA was measured with questionnaires and accelerometers. Several tests were conducted to estimate cardiorespiratory fitness and muscle strength. Body composition was estimated by dual-energy X-ray absorptiometry. DNAmAge estimates from blood and muscle were highly correlated with chronological age, but different age acceleration estimates were weakly associated with each other. The monozygotic twin within-pair similarity of ageing pace was higher in blood (r = 0.617–0.824) than in muscle (r = 0.523–0.585). Associations of age acceleration estimates with PA, physical function and body composition were weak in both tissues and mostly explained by smoking and sex. The muscle-specific epigenetic clock MEAT was developed to predict chronological age, which may explain why it did not associate with functional phenotypes. The Horvath’s clock and GrimAge were weakly associated with PA and related phenotypes, suggesting that higher PA would be linked to accelerated biological ageing in muscle. This may, however, be more reflective of the low capacity of epigenetic clock algorithms to measure functional muscle ageing than of actual age acceleration. Based on our results, the investigated epigenetic clocks have rather low value in estimating muscle ageing with respect to the physiological adaptations that typically occur due to ageing or PA. Thus, further development of methods is needed to gain insight into muscle tissue-specific ageing and the underlying biological pathways.Peer reviewe

Facial pain and temporomandibular disorders

Abstract The study was undertaken to determine the prevalence of facial pain and the association of facial pain with temporomandibular disorders (TMD) as well as with other factors, in a geographically defined population-based sample consisting of subjects born in 1966 in northern Finland, and in a case-control study including subjects with facial pain and their healthy controls. In addition, the influence of conservative stomatognathic and necessary prosthetic treatment on facial pain and TMD was evaluated in a sample of patients with facial pain. In the age group of 31-32-year-olds, facial pain was reported by 12 % of men and 18 % of women. Reported facial pain was strongly associated with TMD symptoms, and a relation was also seen with other factors, i.e. certain occlusal factors, previous traumas, other pain conditions in the body, clinically assessed tenderness in the neck muscles, and psychological problems, such as depressiveness and alexithymia. Conservative treatment of TMD seemed to be effective in relieving facial pain in a one-year follow-up. It can be concluded that facial pain is quite a common symptom with several both localized and generalized associated factors. Conservative stomatognathic treatment is recommended in the case of TMD-related facial pain. The possibility of psychological problems should be taken into account, especially in complex and chronic cases. When no response to conservative stomatognathic treatment is achieved, a multidisciplinary team, including mental health professionals, will be needed in both diagnosis and treatment. This study provides support for the suggestion that in future individualizing treatment of the patients with facial pain should be based on patient characteristics, which may improve treatment efficacy

Bruksismi ja psyykkinen kuormittuneisuus hammaslääketieteen opiskelijoilla

Tiivistelmä Lähtökohdat: Bruksismi määritellään toistuvaksi puremalihasten aktivaatioksi, joka voi olla narskuttelua tai hampaiden tiukkaa yhteen puremista unessa tai valveilla. Keskushermostolla on keskeinen rooli bruksismin synnyssä, ja psyykkisillä kuormitustekijöillä, kuten ahdistuneisuudella ja masentuneisuudella, on yhteys bruksismiin. Tämän tutkimuksen tavoitteena oli selvittää itseraportoitua bruksismin esiintyvyyttä ja sen yhteyttä psyykkiseen kuormittuneisuuteen hammaslääketieteen opiskelijoilla. Menetelmät: Tutkimukseen osallistui 192 hammaslääketieteen opiskelijaa Oulun ja Itä-Suomen yliopistoista. Bruksismia ja psyykkistä kuormittuneisuutta selvitettiin DC/TMD (Diagnostic Criteria for Temporomandibular Disorders) -kriteeristön kyselyillä. Tulokset: Itseraportoidun unibruksismin esiintyvyys opiskelijoilla oli 39,7 %, valvenarskuttelun 19,9 % ja hampaiden lujasti yhteen puremisen 48,4 %. Vähintään lieväasteista psyykkistä kuormittuneisuutta esiintyi ­35 %:lla opiskelijoista. Naisilla hampaiden lujasti yhteen pureminen oli merkitsevästi yhteydessä psyykkiseen kuormittuneisuuteen. Päätelmät: Valvebruksismilla ja psyykkisellä kuormittuneisuudella on yhteyttä. Kuormittuneisuus tulee ottaa huomioon bruksismin hoidossa.Background: Bruxism is defined as repetitive jaw-muscle activity characterized by clenching or grinding of the teeth while either awake or asleep. The aetiology of bruxism is multifactorial and the central nervous system plays an important role. Psychological factors, such as depression and anxiety symptoms, are related to awake and sleep bruxism. Awake bruxism can be grinding or clenching of the teeth. The aim of the study was to examine the prevalence of awake and sleep bruxism and the association of self-reported bruxism with psychological distress in dental students. Methods: Altogether 192 dental students from the University of Oulu and the University of Eastern Finland participated in the study. Bruxism and distress were reported using questionnaires included in the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Results: The prevalence for self-reported sleep bruxism was 39.7%, for awake grinding of the teeth 19.9% and for clenching of teeth 48.4%. Of the students, 35.0% had at least mild psychological distress. Among women, clenching of teeth had a statistically significant association with psychological distress. Conclusions: Awake bruxism is associated with psychological distress and this should be taken into account in the treatment of bruxism

Factors associated with signs of temporomandibular pain:an 11-year-follow-up study on Finnish adults

Abstract Background: Pain in the temporomandibular region is a main complaint causing disability and distress among temporomandibular disorders sufferers. Objectives: The aim of the study was, over an 11-year follow-up on Finnish adult population, to investigate the prevalence of clinically assessed pain-related temporomandibular disorder (TMD) signs, i.e. temporomandibular joint (TMJ) and masticatory muscles (MM) pain on palpation, and their association with sociodemographic background and denture status. Methods: The data were based on the nationally representative Finnish Health 2000 and Health 2011 Surveys (BRIF8901). The sample comprised 1210 adults who underwent clinical oral examinations including TMD signs assessment. Statistical evaluations included chi-square tests and logistic regressions. Results: The prevalence of palpatory MM pain decreased from 9.5% at baseline to 4.6% in the follow-up. Cross-sectionally, presence of palpatory MM pain significantly associated with gender (p < .001, p = .002) and educational level (p < .001, p = .001) in both years, and with age (p = .006) and denture status (p = .022) at baseline. The prevalence of palpatory TMJ pain increased from 2.1% at baseline to 3.5% in the follow-up. Presence of palpatory TMJ pain significantly associated with gender in both years (p = .012, p = .032). Female gender, lower education and palpatory MM pain at baseline predicted palpatory MM pain in the follow-up. Conclusion: Palpatory MM pain is relatively prevalent in adults, yet with a favourable prognosis. Women and people with low education are more susceptible groups. Previous experience of palpatory MM pain increases the risk of exhibiting it later in life

Association between cynical hostility and temporomandibular pain mediated through somatization and depression:an 11-year follow-up study on Finnish adults

Abstract Background: Hostility is believed to have an adverse effect on physical health through mediating psychosocial factors. Objectives: This study aimed to investigate the association of hostility with temporomandibular (TMD) pain. Another aim was to investigate if the association is mediated through increases in depressiveness and somatization in an 11-year follow-up on Finnish adults, based on the Health 2000 and 2011 Surveys (BRIF8901). Material and methods: The sample comprised subjects who underwent clinical TMD pain examination (pain on palpation of the masticatory muscles and temporomandibular joints) in 2000 and 2011 and responded to questions on TMD pain symptoms in 2011. Hostility was measured using the Cynical Distrust Scale, somatization was measured using the Symptom Checklist-90, and depressiveness using Beck’s Depression Inventory-21. Four subgroups were formed based on the presence of TMD pain: no pain, pain in 2000 only, pain in 2011 only, and pain in 2000 and 2011. Analyses included chi-square test cross-sectionally, and multinomial logistic regression longitudinally with the level of hostility in 2000 as the predictor. Mediation analysis was performed using Hayes’ Process v3.5. Results: Those with higher hostility showed a higher prevalence of TMD pain. Longitudinally, the association of hostility with TMD pain in 2000 only, and with TMD pain in both years, was mediated either by somatization only or by depressiveness that was mediated by somatization. In those with TMD pain in 2011 only, the association was mediated by depressiveness that was mediated by somatization. Conclusion: Hostility increased the risk of TMD pain through increases in depressiveness and somatization

Repair bond strength of bulk-fill composites:influence of different primers and direction of debonding stress

Abstract Background: The purpose of this in vitro study was to evaluate the effect of different adhesion primers on the repair bond strength of bulk-fill resin composite and short-term hydrolytic stability of the repair interface before and after accelerated aging. In addition, direction of debonding stress was examined. Materials and methods: Bulk-fill substrates were aged in water for 14 days at 37 °C. Smooth resin composite surfaces were prepared for the substrates with a superfine grinding paper (FEPA #500, #1200, #2000). Test specimens were produced by attaching bulk-fill composite to the substrate surfaces, using three different primer/bonding systems. Specimens were aged 24 h at 37 °C in water, or thermal cycled (5–55 °C/5,000 cycles). Subsequently, shear bond strength and micro-tensile bond strength were evaluated. In total there were 60 specimens for the shear bond strength and 60 specimens for the micro-tensile bond strength measurements (30 stored in water 24 h, 30 thermal cycled, n = 10 in each primer/bonding mode). Results: The mean shear bond strength was 9.1–13.1 MPa after 24 h water storage and 6.9–10.7 MPa after thermal cycling. The mean micro-tensile bond strength was 28.7–45.8 MPa after 24 h water storage and 22.7–37.9 MPa after thermal cycling. Conclusion: The Ceramic primer (silane containing) seems to perform better than the three-step etch and rinse adhesive or the Composite primer. Shear-type stress had an adverse effect on the repair bond strength of bulk-fill resin composites

Low-grade inflammation as a potential mediator between depressive symptoms and temporomandibular pain:an 11-year follow-up study on Finnish adults

Abstract Background: Low-grade inflammation and depressiveness have been associated with chronic pain conditions. Objective: To examine whether low-grade inflammation mediates the association between depressive symptoms and temporomandibular (TM) pain in Finnish adults based on the Health 2000/2011 Surveys (BRIF8901). Methods: The sample comprised subjects who underwent clinical TM pain examination (pain on palpation of the masticatory muscles and temporomandibular joints) in 2000 and 2011 and responded to questions on TM pain symptoms in 2011. The serum level of hs-CRP was obtained in both years, and depressiveness was assessed using the Beck Depression Inventory-21 (BDI-21) in 2000 and BDI-13 in 2011. Four subgroups were formed based on the presence of TM pain: No pain, pain in 2000-only, pain in the 2011-only, and pain in both-years. Analyses included Rao Scott’s chi-square test cross-sectionally, and multinomial logistic regression longitudinally with the level of hs-CRP and BDI-21 score in 2000 as predictors. Mediation was tested using Hayes A. Processv3.5. Results: Higher BDI-21/-13 and hs-CRP levels corresponded to higher prevalences of TM pain in both years. Longitudinally, in men, higher hs-CRP level predicted TM pain in 2000-only and TM pain in both-years. Higher BDI-21 score predicted having TM pain in 2011-only. In women, higher BDI-21 score predicted TM pain in 2000-only and having TM pain in both-years. Both BDI-21 and hs-CRP had a direct effect on TM pain outcome with no mediation detected. Conclusions: While depressiveness may increase the risk of chronic TM pain in women, the risk in men is increased by low-grade inflammation

Role of psychosocial factors on treatment outcome of temporomandibular disorders

Abstract Objectives: The aim of this randomized controlled study was to investigate the effect of depressive and non-specific physical symptoms on treatment outcome of temporomandibular disorders (TMD). Material and methods: Eighty TMD patients were randomly assigned to splint group (n = 39) and control group (n = 41). The patients were classified in terms of depressive and non-specific physical symptoms as normal, moderate or severe using Research Diagnostic Criteria for Temporomandibular Disorders Axis II protocol. The effect of depressive and non-specific physical symptoms on the intensity of facial pain, as measured with visual analogue scale (VAS) was estimated with linear mixed models. The patients’ subjective estimates of the effects of treatment and TMD symptom severity were inquired at 1-year follow-up. Results: At baseline and during the follow-up there were no significant differences in VAS scores between patients in different Axis II subscales. According to the mixed linear regression, depressiveness or nonspecific physical symptoms separately were not significantly associated with the VAS during the study. The association of VAS with depressive (p = .073) and nonspecific physical symptoms (p = .088) approximated statistical significance. Patients with moderate or severe nonspecific physical symptoms (with pain items) at baseline had more frequently moderate, severe or intolerable TMD symptoms after the treatment compared to those who were classified in normal subgroup. Conclusions: The present study gave some indication of a possible negative effect of depressive and nonspecific physical symptoms (with pain items) on TMD treatment response. However, the results should be regarded as preliminary, and further studies with larger sample size are needed to confirm the results