Retrospective evaluation of the incidental finding of 403 papillary thyroid microcarcinomas in 2466 patients undergoing thyroid surgery for presumed benign thyroid disease

This research was aimed to describe the effectiveness of discovery learning model to increase student’s fluency thinking skills on chemical equilibrium subject matter.  The method of the research was quasi-experimental with  Non Equivalent Control Group Design.  The population of this research was all students in XI science class of MA Negeri 1 Metro whose sit in odd semester of academic year 2013-2014.  The sample were taken by purposive sampling technique then obtained XI IPA2 dan XI IPA3 class as sample of the research.  The effectiveness of discovery learning model was showed by the significant difference of n-Gain between control and experiment class.The result of research showed that the average n-Gain score for experiment class was  0,32 and the average n-Gain score for control class was 0,21.  Proving the hypothesis showed that discovery learning model is effective to increase student’s fluency thinking skills on chemical equilibrium subject matter. Tujuan penelitian ini adalah untuk mendiskripsikan efektivitas model discovery learning dalam meningkatkan keterampilan berpikir lancar siswa pada materi kesetimbangan kimia.  Metode dalam penelitian ini adalah kuasi eksperimen.  Populasi dalam peneliian ini adalah semua siswa kelas XI IPA MA Negeri 1 Metro semester ganjil Tahun Pelajaran 2013-2014.  Sampel diambil dengan tehnik purposive sampling sehingga diperoleh kelas XI IPA2 dan XI IPA3 sebagai sampel penelitian.  Efektivitas model discovery learning ditunjukan berdasarkan perbedaan nilai n-Gain yang signifikan antara kelas eksperimen dan kelas kontrol. Hasil penelitian menunjukan rata-rata nilai n-Gain untuk kelas eksperimen adalah 0,32 dan rata-rata nilai n-Gain  untuk kelas kontrol adalah 0,21.  Pengujian hipotesis menunjukan bahwa model discovery learning efektif dalam meningkatkan keterampilan berpikir lancar siswa pada materi kesetimbangan kimia. Kata kunci : kesetimbangan kimia, keterampilan berpikir lancar, model discovery learnin

HIV/AIDS Risk Behaviours among Roma and Non-Roma Sex Workers in Belgrade (Serbia)

The aim of this cross-sectional study was to analyze differences between Roma and non-Roma sex workers (SWs) according to their HIV/AIDS risk behaviors. In this study 91 Roma and 100 non-Roma SWs were included. They offered sex services at Belgrade hot spots during the period 2006–2007. Roma SW were significantly younger and with lower education and they were significantly more often without reading and writing skills than non Roma SW. They also significantly more often had the first sexual intercourse before an age of 14 years. Roma and non-Roma SWs did not differ significantly in their risky sex behaviors. Out of all SWs (both Roma and non-Roma) 13.6% had more than 5 clients daily, 61.3% always used a condom with the commercial sex partners and 17.3% always used a condom with the steady partner. More than half of all participants (55.0%) reported daily use of some psychoactive substance. Correct answers to all 6 standardized questions regarding HIV transmission gave only 9.9% Roma and 5.0% non-Roma SW and mean scores were 2.87 for Roma and 3.03 for non-Roma SW. These differences were not significant. According to multivariate analysis, Roma SWs were significantly younger, less educated, and with more testing to HIV during life in comparison with non Roma SWs. Significantly protective determinants for Roma SWs were knowledge of reading and writing and less frequently daily using of ecstasy during last month in comparison with non Roma SWs. It is necessary to continue work on education of both Roma and non-Roma SWs and to reconsider and revise the existing prevention programs regarding their impact on HIV transmission knowledge and the respective protective behaviors

HIV/AIDS Risk Behaviours among Roma and Non-Roma Sex Workers in Belgrade (Serbia)

The aim of this cross-sectional study was to analyze differences between Roma and non-Roma sex workers (SWs) according to their HIV/AIDS risk behaviors. In this study 91 Roma and 100 non-Roma SWs were included. They offered sex services at Belgrade hot spots during the period 2006–2007. Roma SW were significantly younger and with lower education and they were significantly more often without reading and writing skills than non Roma SW. They also significantly more often had the first sexual intercourse before an age of 14 years. Roma and non-Roma SWs did not differ significantly in their risky sex behaviors. Out of all SWs (both Roma and non-Roma) 13.6% had more than 5 clients daily, 61.3% always used a condom with the commercial sex partners and 17.3% always used a condom with the steady partner. More than half of all participants (55.0%) reported daily use of some psychoactive substance. Correct answers to all 6 standardized questions regarding HIV transmission gave only 9.9% Roma and 5.0% non-Roma SW and mean scores were 2.87 for Roma and 3.03 for non-Roma SW. These differences were not significant. According to multivariate analysis, Roma SWs were significantly younger, less educated, and with more testing to HIV during life in comparison with non Roma SWs. Significantly protective determinants for Roma SWs were knowledge of reading and writing and less frequently daily using of ecstasy during last month in comparison with non Roma SWs. It is necessary to continue work on education of both Roma and non-Roma SWs and to reconsider and revise the existing prevention programs regarding their impact on HIV transmission knowledge and the respective protective behaviors

Psychometric characteristics of the chronic Otitis media questionnaire 12 (COMQ - 12): stability of factor structure and replicability shown by the Serbian version.

BACKGROUND: Recently, demand for and supply of short-form patient-reported outcome measures (PROMs) have risen throughout the world healthcare. Our contribution to meeting that demand has been translating and culturally adapting the Chronic Otitis Media Questionnaire-12 (COMQ-12) for adults into Serbian and enhancing its psychometric base on the relatively large Serbian COM caseload. Chronic otitis media can seriously affect quality of life progressively and in long-term, and it remains the major source of hearing problems in the developing world. METHODS: The translated questionnaire was given twice to 60 adult patients with chronic otitis media of three types (inactive, active mucosal and active squamous disease) and to 60 healthy volunteers. Both patients and volunteers also filled the generic Short-Form 36 questionnaire (SF-36). Conventional statistical procedures were used in strategically driven development of scoring. Additionally, item responses were scaled by linear mapping against the provisional total score. Generalizability, detailed factor interpretation and supportability of scores were criteria, for the best compromise factor solution. RESULTS: Test-retest reliability was very high (0.924 to 0.989, depending on score). The a priori content dimensions of the questionnaire were strongly supported by 3-factor exploratory and confirmatory factor analyses for content validity, separating (i) ear symptoms from (ii) hearing problems, from (iii) daily activity restriction plus healthcare uptake. The 3-factor structure was furthermore highly stable on replication. The very large effect sizes when contrasting patients with healthy volunteers, and active with inactive disease established construct validity for the total score. A strong association with disease activity and a moderate one with generic health-related quality of life (HRQoL), the SF-36, supported construct validity for two of three factors extracted (ear symptoms, and impact on daily activities plus healthcare uptake). CONCLUSIONS: Given the minimal psychometric work to date on COMQ-12, this interim sample with 120 data points adds materially to knowledge of its reliability, several forms of validity and the feasibility of profile sub-scores to supplement total scores. The good psychometric properties shown for COMQ-12 justify both its routine clinical use and acquisition of the necessarily larger sample for generality, score optimisation and the evaluation of responsiveness

Smartphone addiction, sleep quality, depression, anxiety, and stress among medical students

IntroductionStudies consistently link excessive smartphone use to poor sleep quality, depression, anxiety, and stress. This study specifically aimed to investigate these associations among medical students in Belgrade and Nis (Central Serbia).Materials and methodsThe cross-sectional study included a sample of 761 students, who were selected from both the Faculties of Medicine at the University of Belgrade and the University of Nis. Questionnaires, including the International Physical Activity Questionnaire – Short Form (IPAQ-SF), Smartphone Addiction Scale – Short Version (SAS-SV), the Pittsburgh Sleep Quality Index (PSQI), and the Depression, Anxiety, and Stress Scale – 21 items (DASS-21), were completed by the participants. Statistical analysis techniques, such as the Chi-square test, student’s t-test, and logistic regression, were employed to examine the relationship between smartphone addiction, physical activity, sleep quality, depression, anxiety, and stress.ResultsThe findings indicated a prevalence of smartphone addiction among medical students at 21.7%, with rates of 22.9% among males and 21.1% among females. Females exhibited significantly higher scores on the SAS-SV scale compared to males (p = 0.032). Univariate logistic regression analysis revealed significant associations between smartphone addiction and spending over 4 h daily on smartphones (OR = 2.39; p < 0.001), poor sleep quality (OR = 1.65; p = 0,005), as well as elevated levels of stress (OR = 1.75; p = 0.003), anxiety (OR = 2.04; p < 0.001), and depression (OR = 2.29; p < 0.001). Multivariate regression analysis identified spending more than 4 h daily on smartphones (OR = 2.39; p < 0.001) and increased levels of depression (OR = 2.51; p < 0.001) as independent significant factors associated with smartphone addiction.ConclusionThis study sheds light on the prevalence of smartphone addiction among medical students, with spending excessive time on smartphones and higher levels of depression standing out as significant factors. Future research should delve into the underlying mechanisms and causal relationships between smartphone addiction and these psychosocial factors. Understanding these connections will aid in developing effective interventions and strategies to tackle this growing public health concern

Age as a Prognostic Factor in Anaplastic Thyroid Cancer

Background. Anaplastic thyroid cancer (ATC) is one of the tumors with the shortest survival in human medicine. Aim. The aim was to determine the importance of age in survival of patients with ATC. Material and Methods. We analyzed the data on 150 patients diagnosed with ATC in the period from 1995 to 2006. The Kaplan-Meier method and log-rank test were used to determine overall survival. Prognostic factors were identified by univariate and multivariate Cox regression analysis. Results. The youngest patient was 35 years old and the oldest was 89 years old. According to univariate regression analysis, age was significantly associated with longer survival in patients with ATC. In multivariate regression analysis, patients age, presence of longstanding goiter, whether surgical treatment is carried out or not, type of surgery, tumor multicentricity, presence of distant metastases, histologically proven preexistent papillary carcinoma, radioiodine therapy, and postoperative radiotherapy were included. According to multivariate analysis, besides surgery (P=0.000, OR = 0.43, 95% CI = 0.29–0.63), only patients age (P=0.023, OR = 0.68, 95% CI = 0.49–0.95) was independent prognostic factor of favorable survival in patients with ATC. Conclusion. Age is a factor that was independently associated with survival time in ATC. Anaplastic thyroid cancer has the best prognosis in patients younger than 50 years

Penile herpes zoster: an unusual location for a common disease

Herpes zoster is a common dermatological condition which affects up to 20% of the population, most frequently involving the thoracic and facial dermatomes with sacral lesions occurring rarely and only a few reported cases of penile shingles. Case report: We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. The patients presented with grouped clusters of vesicles and erythema on the left side of penile shaft and posterior aspect of the left thigh and buttock, involving s2-s4 dermatomes. The lesions resolved quickly upon administration of oral antiviral therapy. Conclusion: Penile herpes zoster should not be overlooked in patients with unilateral vesicular rash

Penile herpes zoster: an unusual location for a common disease

Herpes zoster is a common dermatological condition which affects up to 20% of the population, most frequently involving the thoracic and facial dermatomes with sacral lesions occurring rarely and only a few reported cases of penile shingles. Case report: We report two cases of unusual penile clinical presentations of varicella zoster virus infection in immunocompetent men. The patients presented with grouped clusters of vesicles and erythema on the left side of penile shaft and posterior aspect of the left thigh and buttock, involving s2-s4 dermatomes. The lesions resolved quickly upon administration of oral antiviral therapy. Conclusion: Penile herpes zoster should not be overlooked in patients with unilateral vesicular rash