35 research outputs found

    The Planteome database:an integrated resource for reference ontologies, plant genomics and phenomics

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    The Planteome project (http://www.planteome.org) provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. The Planteome project is developing a plant gene annotation platform; Planteome Noctua, to facilitate community engagement. All the Planteome ontologies are publicly available and are maintained at the Planteome GitHub site (https://github.com/Planteome) for sharing, tracking revisions and new requests. The annotated data are freely accessible from the ontology browser (http://browser.planteome.org/amigo) and our data repository

    Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models

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    Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer, with 45–50% of primary ductal carcinomas overexpressing this oncoprotein. Targeted deletion of the gene encoding cyclin D1 demonstrates an essential role in normal mammary gland development while transgenic studies provide evidence that cyclin D1 is a weak oncogene in mammary epithelium. In a recent exciting development, Yu et al. demonstrate that cyclin D1-deficient mice are resistant to mammary carcinomas induced by c-neu and v-Ha-ras, but not those induced by c-myc or Wnt-1. These findings define a pivotal role for cyclin D1 in a subset of mammary cancers in mice and imply a functional role for cyclin D1 overexpression in human breast cancer

    A study of the influence of social Darwinism on the ideas of history in China, 1895-1906

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    published_or_final_versionHistoryMasterMaster of Philosoph

    The Tung Wah Hospital, 1869-1896: a study of a medical, social and political institution in Hong Kong

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    published_or_final_versionHistoryDoctoralDoctor of Philosoph

    Epitaxial Electrodeposition of Chiral CuO Films from Copper(II) Complexes of Malic Acid on Cu(111) and Cu(110) Single Crystals

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    Chiral films of CuO were anodically electrodeposited onto Cu(111) and Cu(110) single crystals from alkaline solutions of Cu(ii) complexed with the malate ion. The chirality of the film was directed by the chiral solution precursor. X-Ray diffraction pole figures and stereographic projections were used to determine the absolute configuration of the films. CuO films grown on Cu(111) from l-malate had (111) and (311) orientations and the films grown from d-malate had (111) and (311) orientations. CuO films grown on Cu(110) from l-malate had (110) and (311) orientations, whereas the films grown from d-malate deposition bath had (110) and (311) orientations. The CuO films grown from a racemic malate bath showed only the (111) and (111) orientations on Cu(111) and (110) and (110) orientations on Cu(110). Single crystals of l-, d- and dl-bis(malato)copper(ii) dihydrate complexes were synthesized and the structures were determined with X-ray crystallography. The chiral complexes of bis(malato)copper(ii) dihydrate were each found to belong to the monoclinic space group P2 1 whereas the racemic complex belonged to the centrosymmetric P2 1/c space group. The chiral complexes formed coordination polymers along the b-axis, with the carboxyl group from each complex linking to the axial site of an adjacent Cu(ii) complex. In the complex produced from the racemic mixture, no coordination polymers formed. © 2011 The Royal Society of Chemistry

    Place, identity and immigrant communities: The organisation of the Yulan Festival in post-war Hong Kong

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    In the process of migration, some traditions persist while others do not. The Yulan Festival, also known as the Ghost Festival, continues to be observed by different subethnic Chinese migrant groups in Hong Kong for a variety of reasons. Although the festival organisation accentuates subethnic distinctions, paradoxically it also enables different groups to integrate into the larger community. The activities articulate various meanings of 'place' - as 'ancestral place' on the mainland where the rituals are believed to originate, as the specific locality/neighbourhood in Hong Kong where the festival is held, and Hong Kong as a whole. This article, based on interviews with Chiu Chow and Hoklo participants, shows how they think of the different meanings of 'place', which in turn reflects the way they make sense of the process of migration. © Victoria University of Wellington, 2005.link_to_subscribed_fulltex
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