36 research outputs found
Business Opportunities in Power Supply with Gas Engines in the Health Sector
In the research, we have developed an operational concept based on new energy generation devices, which, in addition to providing heat and electricity, guarantees uninterrupted supply locally and the sale of system services off-site. Based on international experience in the sector, the overall business concept needs to be developed for successful pilot projects. The trends in the technical-economic and regulatory environment examined show that the direction of change, with uncertain outcomes today, is unanimous: they all support the market penetration and the continued profitability of smallscale power plant devices suitable for secondary regulation. An important task is to identify unique elements in the value propositions. The aim of the research is to identify which of the factors such as realized price differential, heat-side revenues, generation utilization, optimized plant operation, scaling, etc. have an impact on the investment, operation, as well as the overall business model and profitability, and to what extent
A gázmotoros áramszolgáltatás üzleti lehetőségei az egészségügyi szektorban
A kutatásban Ăşj energiatermelĹ‘ eszközökre alapozva a hĹ‘- Ă©s villamos energia biztosĂtása mellett helyben a szĂĽnetmentes ellátást szavatolĂł – telephelyen kĂvĂĽlre rendszerszintű szolgáltatás Ă©rtĂ©kesĂtĂ©sĂ©re Ă©pĂtĹ‘ – ĂĽzemeltetĂ©si koncepciĂłt alakĂtottunk ki. A szektorra jellemzĹ‘ nemzetközi tapasztalatok alapján teljes ĂĽzleti koncepciĂłt szĂĽksĂ©ges kialakĂtani a sikeres pilotprojektekhez. A megvizsgált műszaki-gazdasági Ă©s reguláciĂłs környezet tendenciái alapján láthatĂł, hogy a ma mĂ©g bizonytalan kimenetelű változások iránya egyöntetű: mind támogatja a szekunder szabályozásra alkalmas kiserĹ‘művi eszközök piaci tĂ©rnyerĂ©sĂ©t Ă©s profitabilitásának fennmaradását. Fontos feladat az unikális elemek azonosĂtása az Ă©rtĂ©kajánlatokban. A kutatás cĂ©lja annak feltárása, hogy a realizált árkĂĽlönbsĂ©g, a hĹ‘oldali bevĂ©telek, a termelĂ©si kihasználtság, az optimalizált ĂĽzemviteli működtetĂ©s, a mĂ©retezĂ©s stb. közĂĽl melyik Ă©s milyen mĂ©rtĂ©kben van hatással a beruházásra, az ĂĽzemeltetĂ©sre Ă©s összessĂ©gĂ©ben az ĂĽzleti modellre, annak eredmĂ©nyessĂ©gĂ©re
The master role of polarized NIS expression in regulating iodine metabolism in the human body
ABSTRACT Objective: The aim of this study was to investigate how polarized sodium iodide symporter (NIS) expression may regulate iodide metabolism in vivo. Materials and methods: Polarized NIS expression was analyzed in tissues that accumulate iodide by the use of immunohistochemistry and polyclonal antibody against the C-terminal end of human NIS (hNIS). Results: Iodide absorption in the human intestine occurs via NIS expressed in the apical membrane. Iodide is secreted into the lumen of the stomach and salivary glands via NIS expressed in the basolateral membrane and then circulates back from the small intestine to the bloodstream via NIS expressed in the apical membrane. Conclusion: Polarized NIS expression in the human body regulates intestinal-bloodstream recirculation of iodide, perhaps prolonging the availability of iodide in the bloodstream. This leads to more efficient iodide trapping by the thyroid gland. Understanding the regulation and manipulating gastrointestinal iodide recirculation could increase radioiodine availability during theranostic NIS applications