6,612 research outputs found
Long-standing unreduced anterior dislocation of the knee - a case report
A case of long standing unreduced anterior dislocation of the knee for 2 months has been reported which was treated first with open reduction and external fixation at 70° flexion of knee followed by gradual extension of knee. Once full extension was achieved, the cylindrical cast was applied for 3 months. The final range of movement of knee at one year follow up was 5-70º along with painless weight bearing. To conclude, this conservative treatment could be one of the valuable option for the patients who can not undergo major surgery because of genreral health problem, or unable to afford for the surgery especially in developing countries, or not willing for arthrodesis.KEY WORDS: Knee joint; Dislocation; Conservative treatmen
Alternative Synthesis of 2,4-Substituted-1,3-thiazines and 2,5-Substituted-thiazole Derivatives
Aneasy and convenient route for the synthesis of 2,4-substituted thiazine (3–6) and 2,5-substituted thiazole (16) derivatives from phenacetamidines and glycine methyl ester is reported. To the best of our knowledge, this is the first report in which phenacetamidines have been utilized as precursors for thiazine synthesis. The syntheses of novel cyclic fused 1,3-diazabutadienes 13 and 2-aza-1,3-butadiene 17, and iodocyclization of 17 leading to the formation of thiazole 16a are also reported. In this paper a total of twenty novel compounds are reported.Keywords: Phenacetamidines, 1,3-thiazines, thiazoles, cyclization
REVIEW POTENT PHARMACEUTICAL PRODUCTS FROM AQUATIC PLANTS – REVIEW
Several biologically active secondary metabolites from aquatic plants have been extracted and identified using modern instrumental BioTechniques and used in various ways as flavors, food, additives, coloring agents, nutraceuticals, cosmetics, and also as unique source of pharma industries for the discovery or development of new drugs. From algae to aquatic macrophytes belonging to various categories, aquatic plants produce a variety of compounds such as polyketides, peptides, alkaloids, flavonoids, phenolic compounds, terpenes, steroids, quinones, tannins, coumarins, and essential oils commercially involving in antibiotic, antiviral, antioxidant, antifouling, anti-inflammatory, anticancer, cytotoxic, and antimitotic activities; thus making them a rich source of medicinal compounds. Moreover, they are comprehensively used in human therapy, veterinary, agriculture, scientific research, and in countless areas. Importantly these chemicals are exercised for developing new antimicrobial and cancer drugs. Furthermore, antioxidant molecules in aquatic plants and seaweeds have recently been acknowledged. This review contains a consolidated contemporary document consisting of entire knowledge available on pharmaceutical products of aquatic plants and highlights major differences among secondary metabolites found in aquatic (algae) and terrestrial plants
Polyarticular tuberculosis in a young boy: A rare presentation
Abstract Polyarticular tuberculosis involving bilateral hip and bilateral knee joints without obvious pulmonary or disseminated form of tuberculosis in a young boy is presented along with literature review
Colossal magnetocapacitance and scale-invariant dielectric response in phase-separated manganites
Thin films of strongly-correlated electron materials (SCEM) are often grown
epitaxially on planar substrates and typically have anisotropic properties that
are usually not captured by edge-mounted four-terminal electrical measurements,
which are primarily sensitive to in-plane conduction paths. Accordingly, the
correlated interactions in the out-of-plane (perpendicular) direction cannot be
measured but only inferred. We address this shortcoming and show here an
experimental technique in which the SCEM under study, in our case a 600
Angstrom-thick (La1-yPry)0.67Ca0.33MnO3 (LPCMO) film, serves as the base
electrode in a metal-insulator-metal (MIM) trilayer capacitor structure. This
unconventional arrangement allows for simultaneous determination of colossal
magnetoresistance (CMR) associated with dc transport parallel to the film
substrate and colossal magnetocapacitance (CMC) associated with ac transport in
the perpendicular direction. We distinguish two distinct strain-related
direction-dependent insulator-metal (IM) transitions and use Cole-Cole plots to
establish a heretofore unobserved collapse of the dielectric response onto a
universal scale-invariant power-law dependence over a large range of frequency,
temperature and magnetic field.Comment: 32 pages, 4 figures, Supplementary section included, Submitted to
Nature Physic
Nishimori point in random-bond Ising and Potts models in 2D
We study the universality class of the fixed points of the 2D random bond
q-state Potts model by means of numerical transfer matrix methods. In
particular, we determine the critical exponents associated with the fixed point
on the Nishimori line. Precise measurements show that the universality class of
this fixed point is inconsistent with percolation on Potts clusters for q=2,
corresponding to the Ising model, and q=3Comment: 11 pages, 3 figures. Contribution to the proceedings of the NATO
Advanced Research Workshop on Statistical Field Theories, Como 18-23 June
200
Correlation of Foot Bimalleolar Angle and Ultrasonography in Assessing the Severity of Club Foot in Neonates Treated by the Ponseti Method
Introduction: Correlation of Pirani score and foot
bimalleolar (FBM) angle has been used in few studies but
correlation of FBM angle with ultrasonography has never
been evaluated so they are being correlated in assessing the
severity of clubfoot in neonates treated by Ponseti method.
Material and Methods: Thirty-two feet with congenital
talipes equinovarus (CTEV) deformity in neonates were
prospectively treated by the Ponseti method. FBM angle and
ultrasound parameters were measured three times i.e. at the
time of initial presentation, at four weeks of treatment and at
completion of treatment. The feet were divided according to
the Pirani score in groups: one (0-2.0), two (2.5-4) and three
(4.5-6). Correlation between FBM angle and ultrasound
parameters were evaluated using Pearson
correlation/regression.
Results: Correlation between FBM angle and ultrasound
parameters were statistically significant (p-value < 0.05).
Conclusion: Ultrasound has the potential to accurately
depict the pathoanatomy in clubfoot. FBM angle and
ultrasound are objective methods to assess the severity of
clubfoot. FBM angle and ultrasonography correlated in
severity of deformity and correction achieved along the
course of treatment
MUC16 (mucin 16, cell surface associated)
Review on MUC16 (mucin 16, cell surface associated), with data on DNA, on the protein encoded, and where the gene is implicated
Evaluation of the effectiveness of a novel brain-computer interface neuromodulative intervention to relieve neuropathic pain following spinal cord injury: Protocol for a single-case experimental design with multiple baselines
Background: Neuropathic pain is a debilitating secondary condition for many individuals with spinal cord injury. Spinal cord injury neuropathic pain often is poorly responsive to existing pharmacological and nonpharmacological treatments. A growing body of evidence supports the potential for brain-computer interface systems to reduce spinal cord injury neuropathic pain via electroencephalographic neurofeedback. However, further studies are needed to provide more definitive evidence regarding the effectiveness of this intervention. Objective: The primary objective of this study is to evaluate the effectiveness of a multiday course of a brain-computer interface neuromodulative intervention in a gaming environment to provide pain relief for individuals with neuropathic pain following spinal cord injury. Methods: We have developed a novel brain-computer interface-based neuromodulative intervention for spinal cord injury neuropathic pain. Our brain-computer interface neuromodulative treatment includes an interactive gaming interface, and a neuromodulation protocol targeted to suppress theta (4-8 Hz) and high beta (20-30 Hz) frequency powers, and enhance alpha (9-12 Hz) power. We will use a single-case experimental design with multiple baselines to examine the effectiveness of our self-developed brain-computer interface neuromodulative intervention for the treatment of spinal cord injury neuropathic pain. We will recruit 3 participants with spinal cord injury neuropathic pain. Each participant will be randomly allocated to a different baseline phase (ie, 7, 10, or 14 days), which will then be followed by 20 sessions of a 30-minute brain-computer interface neuromodulative intervention over a 4-week period. The visual analog scale assessing average pain intensity will serve as the primary outcome measure. We will also assess pain interference as a secondary outcome domain. Generalization measures will assess quality of life, sleep quality, and anxiety and depressive symptoms, as well as resting-state electroencephalography and thalamic Îł-aminobutyric acid concentration. Results: This study was approved by the Human Research Committees of the University of New South Wales in July 2019 and the University of Technology Sydney in January 2020. We plan to begin the trial in October 2020 and expect to publish the results by the end of 2021. Conclusions: This clinical trial using single-case experimental design methodology has been designed to evaluate the effectiveness of a novel brain-computer interface neuromodulative treatment for people with neuropathic pain after spinal cord injury. Single-case experimental designs are considered a viable alternative approach to randomized clinical trials to identify evidence-based practices in the field of technology-based health interventions when recruitment of large samples is not feasible
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