Does neuromuscular exercise training improve proprioception in ankle lateral ligament injury among athletes? Systematic review and meta-analysis

Aims: The prevalence rate of ankle complexities is increasing at a constant rate among athletes. This study aimed to systematically describe the facts and findings related to the effectiveness of training programs on proprioception among athletes suffering from ankle ligament injury. Methods: A literature search in online libraries (Google Scholar, PubMed, EBSCOhost, and ProQuest) using different search engines was conducted for the systematic review and meta-analysis. The common keywords included NEUROMUSCULAR, EXERCISE, TRAINING, PROPRIOCEPTION, and ATHLETES. Studies related to the topic, having relevant resources, and published within the past 10 years were used as inclusion criteria. Methodological quality was assessed through PEDro scale. A meta-analysis of the selected trials was conducted to assess the effectiveness of intervention. Results: Two hundred research articles were initially selected. After close scrutiny, 15 articles were included. Five moderate to excellent quality trials were selected, which involved 2,459 participants. It has been mainly identified that ankle sprain and its complications can be easily prevented with the help of training programs (five trials, relative risk: 0.69, 96%CI: 0.65-0.87). A statistically significant relationship was identified among athletes regarding the preventive impacts of training on proprioception. Conclusions: Preventive training programs were helpful for athletes in terms of proprioception, thus reducing the risk of ankle sprains.O treinamento neuromuscular melhora a propriocepção em lesão ligamentar lateral do tornozelo entre atletas? Revisão sistemática e metanáliseObjetivos: A taxa de prevalência de lesões no complexo ligamentar lateral vem aumentando entre os atletas a uma velocidade constante. Este estudo teve por objetivo descrever sistematicamente os achados relacionados à eficácia dos programas de treinamento na propriocepção entre atletas com lesão ligamentar do tornozelo. Métodos: Foi realizada uma busca em bases de dados online (Google Scholar, PubMed, EBSCOhost e ProQuest) com o uso de diferentes mecanismos de busca, para revisão sistemática e metanálise. Os descritores comuns foram NEUROMUSCULAR, EXERCISE, TRAINING, PROPRIOCEPTION, e ATHLETES. Os estudos relacionados ao assunto, os que continham recursos relevantes e aqueles publicados nos últimos 10 anos foram usados como critério de inclusão. A qualidade metodológica foi avaliada pela escala PEDro. Foi feita uma metanálise dos estudos selecionados a fim de avaliar a eficácia da intervenção. Resultados: Inicialmente, foram selecionados 200 artigos de pesquisa. Após uma avaliação detalhada, restaram 15 artigos. Cinco estudos de qualidade moderada a excelente foram selecionados, totalizando 2.459 participantes. Verificou-se, principalmente, que o entorse de tornozelo e suas complicações podem ser evitados facilmente com o auxílio de programas de treinamento (cinco estudos, risco relativo: 0,69, IC 96%: 0,65-0,87). Observou-se uma relação estatisticamente significativa em termos dos efeitos preventivos do treinamento na propriocepção entre atletas. Conclusões: Os programas de treinamento preventivos foram úteis aos atletas em termos de propriocepção, reduzindo o risco de entorses de tornozelo.

Does neuromuscular exercise training improve proprioception in ankle lateral ligament injury among athletes?: systematic review and meta-analysis = O treinamento neuromuscular melhora a propriocepção em lesão ligamentar lateral do tornozelo entre atletas?: revisão sistemática e metanálise

Objetivos: A taxa de prevalência de lesões no complexo ligamentar lateral vem aumentando entre os atletas a uma velocidade constante. Este estudo teve por objetivo descrever sistematicamente os achados relacionados à eficácia dos programas de treinamento na propriocepção entre atletas com lesão ligamentar do tornozelo. Métodos: Foi realizada uma busca em bases de dados online ( Google Scholar, PubMed, EBSCOhost e ProQuest) com o uso de diferentes mecanismos de busca, para revisão sistemática e metanálise. Os descritores comuns foram NEUROMUSCULAR, EXERCISE, TRAINING, PROPRIOCEPTION, and ATHLETES. Os estudos relacionados ao assunto, os que continham recursos relevantes e aqueles publicados nos últimos 10 anos foram usados como critério de inclusão. A qualidade metodológica foi avaliada pela escala PEDro. Foi feita uma metanálise dos estudos selecionados a fim de avaliar a eficácia da intervenção. Resultados: Inicialmente, foram selecionados 200 artigos de pesquisa. Após uma avaliação detalhada, restaram 15 artigos. Cinco estudos de qualidade moderada a excelente foram selecionados, totalizando 2. 459 participantes. Verificou-se, principalmente, que o entorse de tornozelo e suas complicações podem ser evitados facilmente com o auxílio de programas de treinamento (cinco estudos, risco relativo: 0,69, IC 96%: 0,65-0,87). Observou-se uma relação estatisticamente significativa em termos dos efeitos preventivos do treinamento na propriocepção entre atletas. Conclusões: Os programas de treinamento preventivos foram úteis aos atletas em termos de propriocepção, reduzindo o risco de entorses de tornozel

Ultrasensitive Reagent for Ratiometric Detection and Detoxification of iAsIII in Water and Mitochondria

Toxicity induced by inorganic arsenic as AsO33– (iAsIII) is of global concern. Reliable detection of the maximum allowed contaminant level for arsenic in drinking water and in the cellular system remains a challenge for the water quality management and assessment of toxicity in the cellular milieu, respectively. A new Ir(III)-based phosphorescent molecule (AS-1; λExt = 415 nm and λEms = 600 nm, Φ = 0.3) is synthesized for the selective detection of iAsIII in an aqueous solution with a ratiometric luminescence response even in the presence of iAsV and all other common inorganic cations and anions. The relatively higher affinity of the thioimidazole ligand (HPBT) toward iAsIII led to the formation of a fluorescent molecule iAsV–HPBT (λExt = 415 nm and λEms = 466 nm, Φ = 0.28) for the reaction of iAsIII and AS-1. An improved limit of quantitation (LOQ) down to 0.2 ppb is achieved when AS-1 is used in the CTAB micellar system. Presumably, the cationic surfactants favor the localization of AS-1@CTABMicelle in mitochondria of MCF7 cells, and this is confirmed from the images of the confocal laser fluorescence scanning microscopic studies. Importantly, cell viability assay studies confirm that AS-1@CTABMicelle induces dose-dependent detoxification of iAsIII in live cells. Further, luminescence responses at 466 nm could be utilized for developing a hand-held device for the in-field application. Such a reagent that allows for ratiometric detection of iAsIII with LOQ of 2.6 nM (0.5 ppb) in water, as well as helps in visualizing its distribution in mitochondria with a detoxifying effect, is rather unique in contemporary literature

Highly Sensitive Optical Sensor for Selective Detection of Fluoride Level in Drinking Water: Methodology to Fabrication of Prototype Device

Excess consumption of fluoride through drinking water and its detrimental effects on human health have been a serious global concern. Therefore, frequent monitoring as well as quantitative determination of fluoride ion (F-) concentration in aqueous media is of vital importance. Herein, we have developed a facile and highly sensitive spectroscopic technique for selective detection of F- in aqueous media using aluminium phthalocyanine chloride (AlPc-Cl) as a sensor. The absorbance as well as steady-state fluorescence intensity of AlPc-Cl has been found to decrease in presence of F- which has been used as a marker for the determination of fluoride ion concentration in water. The structural change in AlPc-Cl after addition of F- has been thoroughly studied by using 19F NMR (Nuclear Magnetic Resonance) spectroscopy. Our detailed steady-state as well as time-resolved fluorescence studies reveal that the quenching mechanism is static in nature due to ground state complexation in between F- and AlPc-Cl molecules. The response of the sensor is found to be linear over the F- concentration regime from 0 to 6 parts per million (ppm) with a detection limit of 0.05 ppm. Additionally, it shows an excellent selectivity as well as an insignificant change in sensitivity even in the presence of interfering iron and aluminium ions. Based on the detailed photophysical study, we have further developed a low cost and portable prototype device which shows an excellent sensitivity with the detection limit of 0.10 ppm. This prototype device has a high prospect for real-time monitoring of fluoride ion concentration especially in remote areas.</p

Nanoparticle-based 'turn-on' scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window.

Ultrasensitive detection of heavy metal ions in available water around us is a great challenge for scientists since long time. We developed an optical technique that combines Rayleigh scattering of UV light (365 nm) and post-sample fluorescence detection from colloidal silver (Ag) nanoparticles (NPs) having a surface plasmon resonance (SPR) band at 420 nm. The efficacy of the technique is tested by the detection of several model toxic ions, including mercury, lead, and methylmercury in aqueous media. The light scattering from the Hg-included/inflated Ag NPs at 395 nm was observed to saturate the light sensor even with ppm-order concentrations of Hg ions in the water sample. However, the pollutant is not detected at lower concentrations at this wavelength. Instead, the fluorescence of a high-pass filter (cut-off at 400 nm) at 520 nm is applied to detect pollutant concentrations of up to several hundreds of ppm in the water sample. We also detected lead and methylmercury as model pollutants in aqueous media and validated the efficacy of our strategy. Finally, we report the development of a working prototype based on the strategy developed for efficient detection of pollutants in drinking/agricultural water