System Oriented Social Scrutinizer: Centered Upon Mutual Profile Erudition

Social recommender systems are getting up more attention for product advertisement and social connectivity. A good recommender               should think about the system and the user. The user will have a preference list of some items and these preferences can be useful in suggesting the things which can help the endorsing system to identify better items. In this paper, the idea of social recommender systems as a pattern matching and regular expression making is used for unification of similarities. The concept of mutual profile pattern expression can be applied on various networking platforms. In these type of shared platforms, people all around the globe share resources and interact with each other. In order to manage or scrutinize users according to their interests and likeness, the mutual profile pattern of users can be used. Further predicting of membership function is performed to show how much extent does the profile matches

Study of management of diaphyseal fracture shaft femur by intramedullary interlocking nail

Background: Aim of this study was to analyze the effectiveness of interlocking nail in management of femoral diaphyseal fractures with special reference to fracture anatomy, pattern and status of stability.Methods: This hospital based prospective study was done in the department of Orthopedics, MGM Medical College Navi Mumbai. A total of 41 patients who were admitted in our institute was included to evaluate management of diaphyseal fracture shaft femur by intramedullary interlocking nail from July 2015 to July 2017. They were asked to follow up at 6 weeks, 3 months and 6 months.Results: Most of the fractures (70.7%) were united in 16-20 weeks while 10 (24.4%) fractures were united in 10-15 weeks and 2 (4.9%) fractures were united in 21-25 weeks. The mean time to union was 16.87±3.09 weeks. In the present study, 26 out of 41 patients had excellent results (63.4%) with full, pain free, function of the extremity. 13 patients with good result (31.8%), 9 patients had flexion deformity 1200, 3 patients had shortening 2 cm, 2 patients had shortening 1 cm. Two patients with fair result (4.8%), both had flexion deformity and none had with poor result. So overall, we had 95.2% excellent to good and 4.8% fair results.Conclusions: Interlocking intramedullary nailing is the most effective ad successful method of definitive primary treatment, in most types of fractures of femur shaft. It provides strong fixation, rotational stability and earliest return to functional status, as rate of healing is good with nailing

SURFACE MODIFICATION OF RING-TRAVELER OF TEXTILE SPINNING MACHINE FOR SUBSTANTIALITY

In this report, a study of the wear mechanisms involved in spinning Ring and Traveler of textile industry have been presented. These components, after surface processing with various coatings techniques, were analyzed on the test rig to analyze the wear mechanism. The objective was accomplished by comparing various plasma sprayed coatings on E52100 steel pins using a Pin-on-Disc machine. The surface morphology as well as mechanical properties of the deposited coatings namely WC-Co-Cr, Al2O3+TiO2 (Alumina-Titania) and Cr3C2NiCr, as well as uncoated E52100, were comparatively studied. This study elucidates towards improving the working life of the Ring in a Textile mill while spinning operation. An X-ray diffractometer (XRD) and Scanning Electron Microscope (SEM) was employed to characterize the unworn and worn surfaces of the specimens. The study revealed that the wear rate of Plasma sprayed thermal coatings enhanced with augmenting load. The Plasma sprayed WC-Co-Cr, Cr3C2NiCr, Al2O3+13TiO2 coatings developed on workpiece pins exhibited a notable decrease in volume loss of the material as compared to uncoated E52100 substrate. WC-Co-Cr coating turned out to be the best performer in terms of lowest cumulative volume loss among all the variants of coatings

SURFACE MORPHOLOGY AND MICROHARDNESS BEHAVIOR OF 316L IN HAP-PMEDM

The development of biomaterials for implants nowadays requires materials with superior mechanical and physical properties for enhanced osseointegration and sustained longevity. This research work was conducted to investigate the influence of nano hydroxyapatite (HAp) powder mixed electrical discharge machining (PMEDM) on surface morphology and microhardness of modified 316L stainless steel surface. The chosen process parameters were discharge current, pulse on/off duration and gap voltage in order to analyze the selected output responses. HAp concentration (15 g/l) along with reverse polarity was kept constant for current experimentation. The experimental results testified that surface morphology of PMEDM surface was significantly improved along with augmentation of 79% in microhardness (HV) of HAp modified surface of medical grade stainless steel. Furthermore, XRD and SEM characterization confirmed the deposition of calcium, phosphorous and inter-metallic compounds on HA-PMEDMed surface. The surface thus produced is expected to facilitate better bone-implant adhesion and bioactivity

Graphene Composite Cutting Tool for Conventional Machining

Cutting is an important process in the manufacturing industry and cutting tool is an important element in machining. It is essential to use good quality cutting tools in arrange to maintain the quality of a product. To retain the performance of cutting tool, various techniques have been utilized like cutting fluid, cutting under MQL, coating, multilayer coating, cryoprocessing, different types of surface texturing, different types of solid lubricants, etc. All these processes have a great impact to enhance the mechanical, thermal, and tribological properties in case of conventional machining process. Nowadays composite engineered materials are very successful in metal cutting industry due to its wear-related application and excellent mechanical and thermal properties. A very few research has been carried out on graphene mixed composite tool material, which has very high demand in manufacturing industries, due to its application as a cutting tool material for machining of Al, copper, or high strength carbon steel. In the end, challenges in the processing of tungsten carbide graphene mixed self-lubricated tool have been identified from the literature. In parallel, the latest improvements to enhance the properties of tungsten carbide-cobalt cutting tool with graphene mixed are reviewed

EXPERIMENTAL INVESTIGATION OF OPTIMAL ED MACHINING PARAMETERS FOR Ti-6Al-4V BIOMATERIAL

The present study investigates optimal parameters for machining of Ti-6Al-4V using EDM with graphite electrode. Herein, another technique of modifying surface properties and enhancing machining rate using electrical discharge machining (EDM) was developed. In the present study, design of experiment (D.O.E) was developed using the Taguchi’s orthogonal array to examine the effect of the input machining factors on the machining characteristics, and to forecast the optimized EDM parameters in terms of peak current, pulse-on time, pulse-off time and applied gap voltage. Each experiment was performed to obtain a hole of 1mm depth on the workpiece. From the results, it is found that the discharge current has significant influence on material removal rate (MRR) and surface roughness (SR) followed by other selected parameters, i.e. pulse-on time, pulse-off time. The MRR augmented steeply with the current and was recorded as maximum at 4 Amps. In-vitro bioactivity test was conducted in the simulated body fluid to examine bioactivity confirming a significant apatite growth on the surface treated with ED sparks. The surface and chemical alteration were analyzed by using Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) along with the identification of the substantially enhanced morphology for clinical success

RGD-tagged helical rosette nanotubes aggravate acute lipopolysaccharide-induced lung inflammation

Rosette nanotubes (RNT) are a novel class of self-assembled biocompatible nanotubes that offer a built-in strategy for engineering structure and function through covalent tagging of synthetic self-assembling modules (G∧C motif). In this report, the G∧C motif was tagged with peptide Arg-Gly-Asp-Ser-Lys (RGDSK-G∧C) and amino acid Lys (K-G∧C) which, upon co-assembly, generate RNTs featuring RGDSK and K on their surface in predefined molar ratios. These hybrid RNTs, referred to as Kx/RGDSKy-RNT, where x and y refer to the molar ratios of K-G∧C and RGDSK–G∧C, were designed to target neutrophil integrins. A mouse model was used to investigate the effects of intravenous Kx/RGDSKy-RNT on acute lipopolysaccharide (LPS)-induced lung inflammation. Healthy male C57BL/6 mice were treated intranasally with Escherichia coli LPS 80 μg and/or intravenously with K90/RGDSK10-RNT. Here we provide the first evidence that intravenous administration of K90/RGDSK10-RNT aggravates the proinflammatory effect of LPS in the mouse. LPS and K90/RGDSK10-RNT treatment groups showed significantly increased infiltration of polymorphonuclear cells in bronchoalveolar lavage fluid at all time points compared with the saline control. The combined effect of LPS and K90/RGDSK10-RNT was more pronounced than LPS alone, as shown by a significant increase in the expression of interleukin-1β, MCP-1, MIP-1, and KC-1 in the bronchoalveolar lavage fluid and myeloperoxidase activity in the lung tissues. We conclude that K90/RGDSK10-RNT promotes acute lung inflammation, and when used along with LPS, leads to exaggerated immune response in the lung

Breast and Cervical Cancer Disparities in Alabama: Current Scenario, Ongoing Efforts to Reduce the Disparity Gaps, and What More We Could be Doing

Over the years, we have made considerable progress in our understanding of the biology of various cancers leading to advancements in cancer management strategies. Consequently, we have witnessed steady improvement in survival rates of cancer patients post-diagnosis, although the progress has been slow for some cancer types. Moreover, the advances in cancer care have not equally benefited all the minority and ethnic populations residing in the United States. The state of Alabama has one of the most diverse demographics in the country and as a result, we witness significant health disparities among our populations. Breast and cervical cancers are two major cancer types that disparately affect the women in our state. Here, we discuss the extent of disparities in the diagnosis and death rates from these cancers in the state of Alabama and potential underlying causes affecting the health outcomes. We also discuss ongoing efforts undertaken to reduce the disparity gaps and provide a perspective for addressing these disparities more effectively. &nbsp