METHODS TO INVESTIGATE HYPERTHERMIA INDUCED BY TUMOR TREATING FIELDS

Tumor Treating Fields (TTFields) are an antineoplastic treatment delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. TTF’s is a non-invasive application of low-intensity (1-3 V/cm), intermediate-frequency (100-500 kHz) alternating electric fields. The predominant mechanism by which TTFields are thought to kill tumor cells is the disruption of mitosis through the depolymerization of microtubules and interruption of the spindle structure leading to mitotic catastrophe and the formation of non-viable daughter cells. Tumor Treating fields do not stimulate nerves and muscle because of their high frequency, and do not generate heat because of their low intensity. However, there is no study to support the mechanism of TTF’s. It is still under research. There is not much research done on the hyperthermia induced by tumor treating fields. It’s still not known whether heat also plays a role in inhibiting cancer growth and killing cancer cells. Our hypothesis is that the TTF’s at 150 kHz frequency induce hyperthermia in pancreatic cancer cells. Two specific aims are set to approach this hypothesis. First specific aim is to design and develop an engineering set up capable of generating frequency with amplitude modulation to induce TTF’s (150kHz). And second aim is to perform experiments on panc-1 cells stained with PEG BODIPY dye cultured in a custom designed Delta T dish using picoquant confocal microscope. Lifetime measurement of the dye clearly suggests that temperature does increase in the cells with time

Genome-wide Insilico analysis of plant two component signaling system in woody model plant Populus trichocarpa

The two-component system (TCS) which works on the principle of histidine-aspartate phosphorelay signaling, is known to play an important role in diverse physiologicalprocesses in lower organisms and emerged as an important signaling system in both prokaryotic as well as eukaryotic systems including plants. Employing various bioinformatics tools, we have characterized TCS signaling candidate genes in the genome of Populus trichocarpa. In this study we present an overview of TCS gene families in P. tricocarpha, including gene structures, conserved motifs, chromosome locations, andphylogeny. This analysis indicates a total of 49 genes out of which at least 12 belongs tohistidine kinases (8 histidine kinase (PtHK) and 4 ethylene responsive (PtETR)), 12 pseudo phosphotransfers(PtHPT) and 9 type-A(PtRRA), 11 type-B (PtRRB), and 5 pseudo-responseregulator proteins (PtPRR) present on different chromosomes. Fourteen genes encode 22putative histidine kinases with a conserved histidine and other typical histidine kinasesignature sequences, five phosphotransfer genes encoding seven phosphotransfer proteins,and 32 response regulator genes encoding 44 proteins. Structural and phylogenetic analysesof populous TCS members with their Arabidopsis and rice counterparts revealed similararchitecture of their TCSs. Our analysis provides insights into the conservation anddivergence of this important signaling machinery in woody plants

Fixed Point Result in Probabilistic Metric Space

In this paper we prove common fixed point theorem for four mapping with weak compatibility in probabilistic metric space. Keywords: Menger space, Weak compatible mapping, Semi-compatible mapping, Weakly commuting mapping, common fixed point. AMS Subject Classification: 47H10, 54H25

Recent advances of biosensors in biomedical sciences

This review discusses recent advances in biosensor technology which draw on the disciplines of physics, chemistry, biochemistry and electronics. We first show that a biosensor consists of three components, a biological detection system, a transducer and an output system. Biological receptors are reviewed, followed by a detailed discussion of transducers, optical, electrochemical, piezoelectric, and others which involve interesting physics and show particular promise for commercial biosensors, are discussed thoroughly. New developments in biosensor design are appearing at a high rate as these devices play increasingly important roles in daily life. We describe a new technology, the Ibis T5000, for the identification of pathogens in clinical and environmental samples; a novel ion channel switch biosensor (ICSB), offers a rapid and sensitive immunodiagnostic for viral detection at point-of care; Chip-NMR, new diagnostic platforms have been developed to measure biomolecule abundance with high sensitivity; Graphene has attracted strong scientific and technological interest in recent years. Finally, future trends in biosensor development are discussed. In this context, bioelectronics, miniaturization, and especially biotechnology seem to be growing areas that will have a marked influence on the development of new biosensing strategies in the next future

A Review on Maximum Power Point Tracking (MPPT) Technique for PV Power Generation System

The growing concern on environmental issues caused by fossil fuels and, indeed, on the availability of such energy resources in a long-run basis have settled the ground for the spreading of the so-called green energy sources. Among them, photovoltaic energy stands out due to the possibility of turning practically any household into a micro power plant. One important aspect about this source of energy is that practical photovoltaic generators are equipped with maximum power point tracking (MPPT) systems. Currently, researchers are focused on developing MPPT algorithms for partial shaded panels. In this paper review is presented on the emerging topologies for PV applications that could be used in the generation of new smart inverters

Evaluation of Representative Smart Grid Investment Grant Project Technologies: Distributed Generation

This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of addition of renewable resources- solar and wind in the distribution system as deployed in the SGIG projects

CLINICAL TRIAL OF DRUG VYAN UTKSHEPAHARA GHAN VATI (KALPIT YOG) IN DIABETES (NIDDM) INDUCED HYERTENSION.

Due to the unwholesome diet, sedentary life style, day by day our country is facing the increasing burden of the patients of diabetes induced high blood pressure, and obesity. Our country is becoming the capital of these diseases. These diseases mostly treated by allopathic medicines which are having considerable side effects and could not be used on long term basis. So conclusion is that in these disease, the dose of allopathic medicines and disease gradually progresses and in addition due to the side effects of allopathic medicines, it is better that these diseases should be treated by Ayurvedic medicines