Continental extension of northern Gondwana margin in the Eastern Himalaya: Constraints from geochemistry and U–Pb zircon ages of mafic intrusives in the Siang window, Arunachal Himalaya, India

We report new U–Pb zircon age and whole-rock geochemical data from the Pangin mafic intrusive rocks of the Siang window, eastern Himalayas. These mafic rocks are medium to coarse-grained gabbros, consisting mainly of plagioclase and clinopyroxene with accessory phases (hornblende $+$ Fe–Ti oxides) that retain granular and interlocking texture. Geochemically, they display enriched-mid oceanic ridge basalt (E-MORB) affinity characterized by moderate to slightly fractionated REE patterns marked by $(\mathrm{La}/\mathrm{Yb})_{\mathrm{N}} = 2.65-3.99$. Their geochemical characteristics suggest that the parental magmas of these rocks were formed by medium to higher degrees (∼12–28%) of partial melting similar to that of the asthenospheric mantle in the garnet-spinel transition zone. Magmatic zircons from two gabbros yield U–Pb ages of 521.50 $\sim$ 2.53 Ma and 568 ${\pm }$ 2 Ma. This new age reveals two pulses of Late Neoproterozoic and Early Cambrian mafic magmatism that are inconsistent with the temporal distribution of Paleozoic magmatism in the Siang window of the Eastern Himalayas. However, based on the results of this study and the correlation of continental extensional mafic magmatism in the Northwest Himalaya, we suggest that investigated mafic intrusive rocks might have been generated in an extensional tectonic environment during the long-lasting Pan-African orogenic cycle of the late Neoproterozoic to early Cambrian which ended with the formation of the Gondwana supercontinent

Continental extension of northern Gondwana margin in the Eastern Himalaya: Constraints from geochemistry and U–Pb zircon ages of mafic intrusives in the Siang window, Arunachal Himalaya, India

We report new U–Pb zircon age and whole-rock geochemical data from the Pangin mafic intrusive rocks of the Siang window, eastern Himalayas. These mafic rocks are medium to coarse-grained gabbros, consisting mainly of plagioclase and clinopyroxene with accessory phases (hornblende $+$ Fe–Ti oxides) that retain granular and interlocking texture. Geochemically, they display enriched-mid oceanic ridge basalt (E-MORB) affinity characterized by moderate to slightly fractionated REE patterns marked by $(\mathrm{La}/\mathrm{Yb})_{\mathrm{N}} = 2.65-3.99$. Their geochemical characteristics suggest that the parental magmas of these rocks were formed by medium to higher degrees (∼12–28%) of partial melting similar to that of the asthenospheric mantle in the garnet-spinel transition zone. Magmatic zircons from two gabbros yield U–Pb ages of 521.50 $\sim$ 2.53 Ma and 568 ${\pm }$ 2 Ma. This new age reveals two pulses of Late Neoproterozoic and Early Cambrian mafic magmatism that are inconsistent with the temporal distribution of Paleozoic magmatism in the Siang window of the Eastern Himalayas. However, based on the results of this study and the correlation of continental extensional mafic magmatism in the Northwest Himalaya, we suggest that investigated mafic intrusive rocks might have been generated in an extensional tectonic environment during the long-lasting Pan-African orogenic cycle of the late Neoproterozoic to early Cambrian which ended with the formation of the Gondwana supercontinent

Human Cytomegalovirus Entry into Dendritic Cells Occurs via a Macropinocytosis-Like Pathway in a pH-Independent and Cholesterol-Dependent Manner

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that is able to infect fibroblastic, epithelial, endothelial and hematopoietic cells. Over the past ten years, several groups have provided direct evidence that dendritic cells (DCs) fully support the HCMV lytic cycle. We previously demonstrated that the C-type lectin dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) has a prominent role in the docking of HCMV on monocyte-derived DCs (MDDCs). The DC-SIGN/HCMV interaction was demonstrated to be a crucial and early event that substantially enhanced infection in trans, i.e., from one CMV-bearing cell to another non-infected cell (or trans-infection), and rendered susceptible cells fully permissive to HCMV infection. Nevertheless, nothing is yet known about how HCMV enters MDDCs. In this study, we demonstrated that VHL/E HCMV virions (an endothelio/dendrotropic strain) are first internalized into MDDCs by a macropinocytosis-like process in an actin- and cholesterol-dependent, but pH-independent, manner. We observed the accumulation of virions in large uncoated vesicles with endosomal features, and the virions remained as intact particles that retained infectious potential for several hours. This trans-infection property was specific to MDDCs because monocyte-derived macrophages or monocytes from the same donor were unable to allow the accumulation of and the subsequent transmission of the virus. Together, these data allowed us to delineate the early mechanisms of the internalization and entry of an endothelio/dendrotropic HCMV strain into human MDDCs and to propose that DCs can serve as a "Trojan horse" to convey CMV from entry sites to other locations that may favor the occurrence of either latency or acute infection

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Brief about Zonal Project DirectorateNot AvailableNot Availabl

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Not AvailableRural development programs act as boon to millions of rural inhabitants globally. So, it becomes extremely important for policy makers to study the perception of grassroot beneficiaries for effective implementation of ongoing program as well as plan for similar programs in future. In this study, the authors have attempted to study an ambitious rural development program named as Sansad Adarsh Gram Yojana launched by Government of India, through the lens of the beneficiaries. The program aims at adoption of villages and transforming them into Model Villages. The perception of the villagers was measured and perceived factors facilitating and inhibiting the program were identified through a multi-dimensional perception scale constructed through Principal Component Method. The study was carried out in four villages of Maharashtra and Telangana during 2018. The perception of 320 respondents when analysed, resulted in factors like Government-Public liaison (Y1=671.86), Infrastructure and Education (Y2=383.14), Local political environment (Y3=267.42), Collective power of villagers and youth (Y4=255.98), Equality (Y5=236.71) and Cultural and inherent values (Y6=143.03) facilitating the program while lack of separate funding (Y10= -12.88), bureaucratic hurdles (Y8=19.09), presence of village factions (Y9=25.05), lack of coordination among government departments (Y11=59.65) and faulty village adoption policy (Y7=130.85) hindering the progress of the program. Majority of villagers from Tikekarwadi (53.33%) of Maharashtra and from Dandepally (56.66%) of Telangana had favourable perception towards potential of the program while villagers from Inovolu (63.33%) of Telangana had neutral perception and from Malunja Budruk (80%) of Maharashtra had unfavourable perception. The classification was done on basis of Cumulative Cube Root Frequency Method (CCRF) and significant difference was found in perception scores of the respondents.Not Availabl

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Not AvailableThe National Agricultural Research System (NARS) is playing a pivotal role in enabling food security by continuous generation of technologies in agriculture and allied sectors in the country. The Indian farming mostly characterized with diversified agro-ecologies, water scarcity, unpredicted rains due to vagaries of monsoon and high cost of technological inputs. Based on the changing scenario of agriculture year by year, it requires promotion of proper management of natural resources like soil, water and micro environment, besides wellbeing of all stakeholders involved in the food production and consumption chain. This is primarily possible by technological empowerment of farmers. As part of such a strategy, the Indian Council of Agricultural Research (ICAR) is playing a crucial role in providing technologies generated by NARS after its assessment, refinement, demonstration in the micro farming situations, in addition to updating the knowledge and skill of farmers and extension personnel by taking up innovative approaches through its network of 589 Krishi Vigyan Kendras (KVKs), which act as knowledge and resource centers for empowering all the partners in the agricultural development process. Over the years, there is a change in agrarian structure, though 80% of farmers are operating small and marginal land holdings and having a weak access to critical production resources. It is expected that India will have the largest agricultural manpower dominated by youths under 30 years of age by 2020. Majority of the Indian youth live in villages and are engaged in agricultural activities. Keeping in view such a situation, the KVKs are effectively addressing the felt needs of farming community especially rural youth by following plough to plate approach and creating an enterprising environment. In order to reach the farmers efficiently, a number of activities are carried out by the entire KVK system to bring out location specific technology modules and appropriate extension approaches. It is therefore very important to review and analyze the input, output, outcome and impact of technological interventions implemented by KVKs by documenting the success achieved and to reorient the strategies for effective functioning of KVKs for fulfilling its mandate. In this direction, the Division of Agricultural Extension of ICAR has made a critical review of success stories emerged from KVKs through a rigorous process followed by the Programme Coordinators at district level, the Zonal Project Directorates at Zonal level and by the Division at national level. Altogether 101 salient technological interventions which proved success have been chosen as a testimony of hard work put in by KVK system and are presented in the form of this document. There is no denying the fact that until the full potential of technology modules tested and demonstrated by KVKs are harvested by the millions of farmers in the country, success cannot be truly translated into production gains at the field level. It is hoped that this attempt may direct the KVKs and the farming community for up-scaling and replication of successful enterprising interventions for teaching the untaught and reaching the unreached.Not Availabl

Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

BACKGROUND: Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy of current pain-killers and prophylactic treatments stands among the main reasons for this phenomenon. Botulinum neurotoxin (BoNT) represents a well-established and licensed treatment for chronic migraine, but also an emerging treatment for other types of primary headache, trigeminal neuralgia, neuropathic pain, and an increasing number of pain conditions. METHODS: We searched and critically reviewed evidence for the efficacy of BoNT for the treatment of chronic pain. RESULTS: Meta-analyses and randomized controlled trials (RCTs) suggest that BoNT potentially represents a multi-purpose drug for the treatment of pain in several disorders due to a favorable safety profile and a long-lasting relief after a single injection. CONCLUSIONS: BoNT is an emerging treatment in different pain conditions. Future RCTs should explore the use of BoNT injection therapy combined with systemic drugs and/or physical therapies as new pain treatment strategies