897 research outputs found
Ariel - Volume 10 Number 2
Executive Editors
Madalyn Schaefgen
David Reich
Business Manager
David Reich
News Editors
Medical College
Edward Zurad
CAHS
John Guardiani
World
Mark Zwanger
Features Editors
Meg Trexler
Jim O\u27Brien
Editorials Editor
Jeffrey Banyas
Photography and Sports Editor
Stuart Singer
Commons Editor
Brenda Peterso
Ariel - Volume 10 Number 6
Executive Editors
Madalyn Schaefgen
David Reich
Business Manager
David Reich
News Editors
Medical College
Edward Zurad
CAHS
John Guardiani
World
Mark Zwanger
Features Editors
Meg Trexler
Jim O\u27Brien
Editorials Editor
Jeffrey Banyas
Photography and Sports Editor
Stuart Singer
Commons Editor
Brenda Peterso
Major Powers and Militarized Conflict
This article attempts to answer the question of why major powers engage in more active foreign policy behaviors than minor powers. It does so by comparing two explanations for the increased conflict propensity of major powers. The first explanation focuses on major powers’ observable capabilities, while the second stresses their different behavior. We incorporate both into an ultimatum model of conflict in which a state’s cost of conflict consists of both observable and behavioral components. Using data from the period from 1870 to 2001, we empirically illustrate the observable and behavioral differences between major and minor powers. We then utilize a decomposition model to assess the relative significance of the two explanations. The results suggest that most of the difference in conflict propensity between major and minor powers can be attributed to observable differences
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Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection.
BackgroundChronic lung allograft dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Because effective therapies are lacking, early identification and mitigation of risk factors is a pragmatic approach to improve outcomes. Acute cellular rejection (ACR) is the most pervasive risk factor for CLAD, but diagnosis requires transbronchial biopsy, which carries risks. We hypothesized that gene expression in the bronchoalveolar lavage (BAL) cell pellet (CP) could replace biopsy and inform on mechanisms of CLAD.MethodsWe performed RNA sequencing on BAL CPs from 219 lung transplant recipients with A-grade ACR (n = 61), lymphocytic bronchiolitis (n = 58), infection (n = 41), or no rejection/infection (n = 59). Differential gene expression was based on absolute fold difference >2.0 and Benjamini-adjusted p-value ≤0.05. We used the Database for Annotation, Visualization and Integrated Discovery Bioinformatics Resource for pathway analyses. For classifier modeling, samples were randomly split into training (n = 154) and testing sets (n = 65). A logistic regression model using recursive feature elimination and 5-fold cross-validation was trained to optimize area under the curve (AUC).ResultsDifferential gene expression identified 72 genes. Enriched pathways included T-cell receptor signaling, natural killer cell-mediated cytotoxicity, and cytokine-cytokine receptor interaction. A 4-gene model (AUC = 0.72) and classification threshold defined in the training set exhibited fair performance in the testing set; accuracy was 76%, specificity 82%, and sensitivity 60%. In addition, classification as ACR was associated with worse CLAD-free survival (hazard ratio = 2.42; 95% confidence interval = 1.29-4.53).ConclusionsBAL CP gene expression during ACR is enriched for immune response pathways and shows promise as a diagnostic tool for ACR, especially ACR that is a precursor of CLAD
Ariel - Volume 10 Number 3
Executive Editors
Madalyn Schaefgen
David Reich
Business Manager
David Reich
News Editors
Medical College
Edward Zurad
CAHS
John Guardiani
World
Mark Zwanger
Features Editors
Meg Trexler
Jim O\u27Brien
Editorials Editor
Jeffrey Banyas
Photography and Sports Editor
Stuart Singer
Commons Editor
Brenda Peterso
Species Abundance Modelling of Arctic-Boreal Zone Ducks Informed by Satellite Remote Sensing
The Arctic-Boreal zone (ABZ) covers over 26 million km2 and is home to numerous duck species; however, understanding the spatiotemporal distribution of their populations across this vast landscape is challenging, in part due to extent and data scarcity. Species abundance models for ducks in the ABZ commonly use static (time invariant) habitat covariates to inform predictions, such as wetland type and extent maps. For the first time in this region, we developed species abundance models using high-resolution, time-varying wetland inundation data produced using satellite remote sensing methods. This data captured metrics of surface water extent and inundated vegetation in the Peace Athabasca Delta, Canada, which is within the NASA Arctic Boreal Vulnerability Experiment core domain. We used generalized additive mixed models to demonstrate the improved predictive value of this novel data set over time-invariant data. Our findings highlight both the potential complementarity and efficacy of dynamic wetland inundation information for improving estimation of duck abundance and distribution at high latitudes. Further, these data can be an asset to spatial targeting of biodiversity conservation efforts and developing model-based metrics of their success under rapidly changing climatic conditions
Gauge invariance and finite width effects in radiative two-pion tau lepton decay
The contribution of the rho^{\pm} vector meson to the tau -> pi pi nu gamma
decay is considered as a potential source for the determination of the magnetic
dipole moment of this light vector meson. In order to keep gauge-invariance of
the whole decay amplitude, a procedure similar to the fermion loop-scheme for
charged gauge bosons is implemented to incorporate the finite width effects of
the rho^{\pm} vector meson. The absorptive pieces of the one-loop corrections
to the propagators and electromagnetic vertices of the rho^{\pm} meson and
W^{\pm} gauge boson have identical forms in the limit of massless particles in
the loops, suggesting this to be a universal feature of spin-one unstable
particles. Model-dependent contributions to the tau -> pi pi nu gamma decay are
suppressed by fixing the two-pion invariant mass distribution at the rho meson
mass value. The resulting photon energy and angular distribution is relatively
sensitive to the effects of the rho magnetic dipole moment.Comment: 22 pages, 4 postscript figures, references and comments on relevance
of perturbative treatment of rho electromagnetic vertex are added, accepted
for pub. in Phys. Rev.
Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
Inner hair cells (IHCs), the primary sensory receptors of the mammalian cochlea, fire spontaneous Ca2+ action potentials before the onset of hearing. Although this firing activity is mainly sustained by a depolarizing L-type (CaV1.3) Ca2+ current (ICa), IHCs also transiently express a large Na+ current (INa). We aimed to investigate the specific contribution of INa to the action potentials, the nature of the channels carrying the current and whether the biophysical properties of INa differ between low- and high-frequency IHCs. We show that INa is highly temperature-dependent and activates at around −60 mV, close to the action potential threshold. Its size was larger in apical than in basal IHCs and between 5% and 20% should be available at around the resting membrane potential (−55 mV/−60 mV). However, in vivo the availability of INa could potentially increase to >60% during inhibitory postsynaptic potential activity, which transiently hyperpolarize IHCs down to as far as −70 mV. When IHCs were held at −60 mV and INa elicited using a simulated action potential as a voltage command, we found that INa contributed to the subthreshold depolarization and upstroke of an action potential. We also found that INa is likely to be carried by the TTX-sensitive channel subunits NaV1.1 and NaV1.6 in both apical and basal IHCs. The results provide insight into how the biophysical properties of INa in mammalian cochlear IHCs could contribute to the spontaneous physiological activity during cochlear maturation in vivo
Ariel - Volume 11 Number 1
Executive Editors
Ellen Feldman
Leonardo S. Nasca, Jr.
Business Managers
Barbara L. Davies
Martin B. Getzow
News Editor
Aaron D. Bleznak
Features Editor
Dave Van Wagoner
CAHS Editor
Joan M. Greco
Editorial Page Editor
Samuel Markind
Photography Editor
Leonardo S. Nasca, Jr.
Sports Editor
Paul F. Mansfiel
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