Urban Flood Prediction through GIS-Based Dual-Coupled Hydraulic Models

Propagation of pluvial floods in urban areas, occurring with return time periods of few years, can be well solved using dual models accounting for the mutual relationship between the water level in the streets and the discharges inside the sewer pipes. The extended WEC-flood model (EWEC), based on the use of unstructured triangular meshes and a diffusive formulation of the momentum equations in both the 2D and the 1D lower domains, is presented along with its novelty, limits, and advantages. The model is then applied to a small computational domain in the Palermo area, where only some 'hard' data given by one rain gauge has been used for calibration and validation, along with other 'soft' data like yes/no surcharge observations and water depths available from photos and interviews. Model input data are mainly geometrical parameters, and calibration parameters are restricted only to average Manning coefficients. In the test case a very good validation has been obtained of three historical events using the EWEC model, with only one average Manning coefficient calibrated using other two historical events

Precision medicine in heart failure no longer a visual theory but a realistic opportunity

Over the last decades, major advances in the understanding of pathophysiology in a wide spectrum of cardiovascular diseases provided several effective pharmacological and non-pharmacological therapies [1]. Along with novel rehabilitation and follow up strategies, these advances have improved the survival rate of cardiac diseases, globally, and contributed generally to a significant increase in life expectancy [2]. As a consequence, there is a parallel increase of patients suffering from challenging and multifaceted syndromes such as heart failure (HF). HF is a recognised pandemic disease, with a progressively increasing prevalence in the aging population [3]. It is a major public health issue, considering both its social and economic implications. HF patients are characterised by a high level of complexity because of the advanced age and the presence of multiple relevant comorbidities requiring dedicated polytherapy [1]. Therefore, overall mortality of HF patients is still unacceptably high, exceeding that of several neoplasms, carrying a risk of approximately 10% at 12 months from clinical onset [4]

Calcolo della portata di piena con modello bidimensionale non lineare

Si propone un modello bidimensionale di trasformazione afflussi-deflussi per il calcolo della piena in una sezione di un corso d\u2019acqua. Il bacino idrografico \ue8 rappresentato da una mesh triangolare non strutturata. L\u2019input del modello \ue8 costituito dalle piogge lorde, trasformate in piogge nette mediante l\u2019equazione integrata di Horton. Il calcolo della propagazione idraulica nei diversi rami della rete idrografica consente di abbandonare le ipotesi di stazionariet\ue0 e di linearit\ue0, ordinariamente adottate nell\u2019idrologia delle piene. Il modello proposto viene calibrato ed applicato ad un bacino idrografico di un affluente del fiume Tevere per il quale si dispongono di alcuni idrogrammi di piena e delle relative piogge

Reverse remodeling in Dilated Cardiomyopathy: Insights and future perspectives

Dilated Cardiomyopathy (DCM) has been classically considered a progressive disease of the heart muscle that inexorably progresses towards refractory heart failure, ventricular arrhythmias and heart transplant. However, the prognosis of DCM has significantly improved in the past few years, mostly as the result of successful therapy-induced reverse remodeling. Reverse remodeling is a complex process that involves not only the left ventricle, but also many other cardiac structures and it is now recognized both as a measure of therapeutic effectiveness and as an important prognostic tool. Nevertheless, several aspects of reverse remodeling remain unclear, including the best timing for its quantification, its predictors and its interaction with individual genetic backgrounds. In this review, we summarize our current understanding of reverse remodeling in patients with DCM and provide practical recommendations for the clinical management of this challenging patient population

Myocarditis evolving in cardiomyopathy: When genetics and offending causes work together

Myocarditis is an infectious-inflammatory disease often superimposed to individual genetic background which could favour or inhibit its progression into a chronic heart muscle disorder (most often dilated cardiomyopathy, rarely arrhythmogenic, or right-sided cardiomyopathy). Post-myocarditis cardiomyopathy is likely caused by a complex interaction between the viral infection and an individual predisposition. Some viruses are able to highlight a clinical phenotype replicating a model similar to the genetically determined conditions, while other can affect the resolution or the progressive remodelling of the left ventricle after the infectious process. The identification of specific individual genetic backgrounds, or genes favouring the progression of the disease, are important future research goals for precision medicine aiming at a specific and individualized treatment for patients affected with myocarditis

Long-Term Follow-Up of a Nonprogressive Left Main Coronary Artery Fistula to Right Atrium

Coronary artery fistula is a rare cardiac abnormality, occurring more frequently in young patients and treated with cardiac surgery or percutaneous interventions in most cases. We present the case of a 63-year-old man with an incidental diagnosis of coronary artery fistula, treated with conservative strategy. (Level of Difficulty: Intermediate.

The American Girl Retail Experience

The American Girl brand is characterized by its ability to promote identity development in young girls through play and educational experiences. Due to the accessibility of smart-devices (e.g. mobile and web based technologies) and the frequency of their use, recent trends in toy designs have shown an increase in digital/technology features. Taking this into consideration, American Girl has continuously emphasized doll-centric products and experiences that also satisfy consumer’s digital interests. American Girl’s interactive digital resources include: the entire American Girl website which features a wide selection of Games, Apps, activities, e-cards, the InnerStar University (i.e., an interactive world for My American Girl Dolls and their owners that provides girls with games, advice and new friends) as well as information about how to plan a trip to your local retail store. Again, the inherent theme in each of these digital activities is the doll. American Girl uses doll-centric activities in retail stores to promote the “American Girl” experience. For this project we examined all aspects of the American Girl Retail Experience ranging from making reservations to planning parties, events, and excursions. Our approach to developing this proposal came from observations of the American Girl Place in Chicago, Illinois and the American Girl Store in Orlando, Florida. We also conducted a review of digital resources such as the American Girl website, 2013 Mattel Annual Report, press releases, videos, and Apps available in the iTunes store. The American Girl website provided us with information about all of the current in-store experiences (e.g. book reading, craft making, cookie decorating, hair styling and more) as well as the current list of products and respective pricing. These details strongly influenced the development of our design. Our proposal examined the user experience from the perspective of the performing arts. The proposal outlines the performing arts experience which suggests the need for a performance stage and describes the activities and events that go along with the stage

Performance improvement of a drag hydrokinetic turbine

Hydropower is at present in many locations, among all the other possible renewable energy sources, the best one for net cost per unit power. In contrast to traditional installation, based on water storage in artificial basins, free flow river turbines also provide a very low environmental impact due to their negligible effect on solid transport. Among them, kinetic turbines with vertical axis are very inexpensive and have almost zero impact on fish and local fauna. In application to tidal waves and sea waves, where vertically averaged velocities have alternate direction, a Savonius rotor also has the advantage of being productive during the whole time cycle. In this work, the effect of an upstream deflector system mounted upstream of a twisted Savonius rotor inside a channel has been investigated through numerical simulations and experimental tests. Numerical simulations were carried on using the ANSYS FLUENT 17.0 software. Based on this numerical study, it is shown that the proposed deflector system has improved the power coefficient of the Savonius rotor by 14%. The utilization of this new design system is predicted to contribute towards a more efficient use of flows in rivers and channels for electricity production in rural areas