Static aerodynamic characteristics of the S-IC booster/GAC H-33 orbiter launch vehicle configuration

This test at the trisonic tunnel was divided into two parts. The first part utilized the H-33 orbiter with drop tanks and cradle mounted on an S-IC booster with 75 square-foot fins oriented 45 deg off the horizontal and vertical reference planes. Runs were initially made to determine the optimum incidence angle to be used for the remainder of the tests. The angle so determined was 0 degrees. Additional testing was performed with drop tanks removed, orbiter vertical tail removed, drop tanks and orbiter wing removed, booster fins removed and booster fins located in the horizontal and vertical reference planes. The second part utilized the H-33 orbiter and cradle only, sting mounted on a strain gage balance. These data were used in conjunction with test number 504 (orbiter alone on balance) to determine cradle effects

Human Health Effects Assays

Discussion of the exponential increase in environmental toxicological information and an approach for organizing and using the information was presented by Lu and Wassom.1 A user\u27s guide to the Registry of Toxic Effects of Chemical Substances (RTECS) was published by NIOSH2 that defines the record layouts and describes the types of data contained in the computer tape version of the 1984 Edition of the RTECS.3 A text summarizing information on approximately 800 toxic chemicals was edited by Sittig.4 Milestone publications concerning fundamentals of toxicology with environmental applications included the works of Gentile,5 Ashby,6 Mortel mans,7 Thacker,8 and Ruppert.9 Brusick and Auletta10 discussed the developmental status of bioassays in genetic toxicology reviewed by the U. S. Environmental Protection Agency (EPA) Gene-Tox Work Groups

Bioremediation of Contaminated Surface Soils

Biological remediation of soils contaminated with organic chemicals is an alternative treatment technology that can often meet the goal of achieving a permanent clean-up remedy at hazardous waste sites, as encouraged by the U.S. Environmental Protection Agency (U.S. EPA) for implementation of The Superfund Amendments and Authorization Act (SARA) of 1986. Bioremediation is consistent with the philosophical thrust of SARA, for it involves the use of naturally occurring microorganisms to degrade and/or detoxify hazardous constituents in the soil at a contaminated slip to protect public health and the environment.Bioremediation of contaminated soils, including applications and limitations, has been addressed

Accuracy of pulse interval timing in ambulatory blood pressure measurement

Blood pressure (BP) monitors rely on pulse detection. Some blood pressure monitors use pulse timings to analyse pulse interval variability for arrhythmia screening, but this assumes that the pulse interval timings detected from BP cuffs are accurate compared with RR intervals derived from ECG. In this study we compared the accuracy of pulse intervals detected using an ambulatory blood pressure monitor (ABPM) with single lead ECG. Twenty participants wore an ABPM for three hours and a data logger which synchronously measured cuff pressure and ECG. RR intervals were compared with corresponding intervals derived from the cuff pressure tracings using three different pulse landmarks. Linear mixed effects models were used to assess differences between ECG and cuff pressure timings and to investigate the effect of potential covariates. In addition, the maximum number of successive oscillometric beats detectable in a measurement was assessed. From 243 BP measurements, the foot landmark of the oscillometric pulse was found to be associated with fewest covariates and had a random error of 9.5 ms. 99% of the cuff pressure recordings had more than 10 successive detectable oscillometric beats. RR intervals can be accurately estimated using an ABPM

Opportunistic detection of atrial fibrillation using blood pressure monitors: a systematic review

Background: Atrial Fibrillation (AF) affects around 2% of the population and early detection is beneficial, allowing patients to begin potentially life-saving anticoagulant therapies. Blood pressure (BP) monitors may offer an opportunity to screen for AF. Aim: To identify and appraise studies which report the diagnostic accuracy of automated BP monitors used for opportunistic AF detection. Methods: A systematic search was performed of the Medline, Medline-in-process and Embase literature databases. Papers were eligible if they described primary studies of the evaluation of a BP device for AF detection, were published in a peer reviewed journal and reported values for the sensitivity and specificity. Included studies were appraised using the QUADAS-2 tool to assess their risk of bias and applicability to opportunistic AF detection. Values for the sensitivity and specificity of AF detection were extracted from each paper and compared. Results and Conclusion: We identified seven papers evaluating six devices from two manufacturers. Only one study scored low risk in all of the QUADAS-2 domains. All studies reported specificity greater than 85% and six reported sensitivity greater than 90%. The studies showed that blood pressure devices with embedded algorithms for detecting arrhythmias show promise as screening tools for AF, comparing favourably with manual pulse palpation. But the studies used different methodologies and many were subject to potential bias. More studies are needed to more precisely define the sensitivity and specificity of opportunistic screening for AF during blood pressure measurement before its clinical utility in the population of interest can be assessed fully

In Situ Bioremediation of Contaminated Unsaturated Subsurface Soils

An emerging technology for the remediation of unsaturated subsurface soils involves the use of microorganisms to degrade contaminants which are present in such soils. Understanding the processes which drive in situ bioremediation, as well as the effectiveness and efficiency of the utilization of these systems, are issues which have been identified by the Regional Superfund Engineering Forum as concerns of Superfund decision makers

How did the COVID-19 pandemic affect the anxiety of teachers at work?

This paper explores teachers’ anxiety about work at 75 timepoints between October 2019 and July 2022, covering the period before, during and towards the end of the COVID-19 pandemic in England. We find the work-related anxiety of headteachers increased substantially throughout the pandemic–much more so than amongst more junior staff. Female teachers experienced a greater impact than men, particularly amongst those with young children. Differences were also observed in work-related anxiety between independent and state schoolteachers, though only during the first lockdown. We illustrate how providing onsite instruction, live online lessons and working longer hours were all associated with raised levels of work-related anxiety

Short-Chained Oligo(Ethylene Oxide)-Functionalized Gold Nanoparticles: Realization Of Significant Protein Resistance

Protein corona formed on nanomaterial surfaces play an important role in the bioavailability and cellular uptake of nanomaterials. Modification of surfaces with oligoethylene glycols (OEG) are a common way to improve the resistivity of nanomaterials to protein adsorption. Short-chain ethylene oxide (EO) oligomers have been shown to improve the protein resistance of planar Au surfaces. We describe the application of these EO oligomers for improved protein resistance of 30 nm spherical gold nanoparticles (AuNPs). Functionalized AuNPs were characterized using UV-Vis spectroscopy, dynamic light scattering (DLS), and zeta potential measurements. Capillary electrophoresis (CE) was used for separation and quantitation of AuNPs and AuNP-protein mixtures. Specifically, nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM) was employed for the determination of equilibrium and rate constants for binding between citrate-stabilized AuNPs and two model proteins, lysozyme and fibrinogen. Semi-quantitative CE analysis was carried out for mixtures of EO-functionalized AuNPs and proteins, and results demonstrated a 2.5-fold to 10-fold increase in protein binding resistance to lysozyme depending on the AuNP surface functionalization and a 15-fold increase in protein binding resistance to fibrinogen for both EO oligomers examined in this study

Revised target co-ordinates for the Beagle 2 lander

The revised, IAU 2000 target co-ordinates of the Mars Beagle 2 lander are 11.6oN, 90.75oE