Carbon-Enhanced Metal-Poor Stars. III. Main-Sequence Turn-Off Stars from the SDSS/SEGUE Sample

The chemical compositions of seven Carbon-Enhanced Metal-Poor (CEMP) turn-off stars are determined from high-resolution spectroscopy. Five of them are selected from the SDSS/SEGUE sample of metal-poor stars. The effective temperatures of these objects are all higher than 6000 K, while their metallicities, parametrized by [Fe/H], are all below -2. Six of our program objects exhibit high abundance ratios of barium ([Ba/H]> +1), suggesting large contributions of the products of former AGB companions via mass transfer across binary systems. Combining our results with previous studies provides a total of 20 CEMP main-sequence turn-off stars for which the abundances of carbon and at least some neutron-capture elements are determined. Inspection of the [C/H] ratios for this sample of CEMP turn-off stars show that they are generally higher than those of CEMP giants; their dispersion in this ratio is also smaller. We take these results to indicate that the carbon-enhanced material provided from the companion AGB star is preserved at the surface of turn-off stars with no significant dilution. In contrast, a large dispersion in the observed [Ba/H] is found for the sample of CEMP turn-off stars, suggesting that the efficiency of the s-process in very metal-poor AGB stars may differ greatly from star to star. Four of the six stars from the SDSS/SEGUE sample exhibit kinematics that are associated with membership in the outer-halo population, a remarkably high fraction.Comment: 45 pages, 10 figures, 10 tables, Astrophysical Journal, in pres

Figuring Out Gas & Galaxies In Enzo (FOGGIE) V: The Virial Temperature Does Not Describe Gas in a Virialized Galaxy Halo

The classical definition of the virial temperature of a galaxy halo excludes a fundamental contribution to the energy partition of the halo: the kinetic energy of non-thermal gas motions. Using simulations of low-redshift, $\sim L^*$ galaxies from the FOGGIE project (Figuring Out Gas & Galaxies In Enzo) that are optimized to resolve low-density gas, we show that the kinetic energy of non-thermal motions is roughly equal to the energy of thermal motions. The simulated FOGGIE halos have $\sim 2\times$ lower bulk temperatures than expected from a classical virial equilibrium, owing to significant non-thermal kinetic energy that is formally excluded from the definition of $T_\mathrm{vir}$. We derive a modified virial temperature explicitly including non-thermal gas motions that provides a more accurate description of gas temperatures for simulated halos in virial equilibrium. Strong bursts of stellar feedback drive the simulated FOGGIE halos out of virial equilibrium, but the halo gas cannot be accurately described by the standard virial temperature even when in virial equilibrium. Compared to the standard virial temperature, the cooler modified virial temperature implies other effects on halo gas: (i) the thermal gas pressure is lower, (ii) radiative cooling is more efficient, (iii) O VI absorbing gas that traces the virial temperature may be prevalent in halos of a higher mass than expected, (iv) gas mass estimates from X-ray surface brightness profiles may be incorrect, and (v) turbulent motions make an important contribution to the energy balance of a galaxy halo.Comment: 30 pages, 14 figures, accepted to Ap

Figuring Out Gas & Galaxies in Enzo (FOGGIE). III. The Mocky Way:Investigating Biases in Observing the Milky Way's Circumgalactic Medium

The circumgalactic medium (CGM) of the Milky Way is mostly obscured by nearby gas in position-velocity space because we reside inside the Galaxy. Substantial biases exist in most studies on the Milky Way's CGM that focus on easier-to-detect high-velocity gas. With mock observations on a Milky-Way analog from the FOGGIE simulation, we investigate four observational biases related to the Milky Way's CGM. First, QSO absorption-line studies probe a limited amount of the CGM mass: only 35% of the mass is at high Galactic latitudes $|b|>20$ degrees, of which only half is moving at $|v_{\rm LSR}|\gtrsim100$ km s$^{-1}$. Second, the inflow rate ($\dot{M}$) of the cold gas observable in HI 21cm is reduced by a factor of $\sim10$ as we switch from the local standard of rest to the galaxy's rest frame; meanwhile $\dot{M}$ of the cool and warm gas does not change significantly. Third, OVI and NV are promising ions to probe the Milky Way's outer CGM ($r\gtrsim$15 kpc), but CIV may be less sensitive. Lastly, the scatter in ion column density is a factor of 2 higher if the CGM is observed from inside-out than from external views because of the gas radial density profile. Our work highlights that observations of the Milky Way's CGM, especially those using HI 21cm and QSO absorption lines, are highly biased. We demonstrate that these biases can be quantified and calibrated through synthetic observations with simulated Milky-Way analogs.Comment: ApJ in pres

Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model

Intraperitoneal (IP) chemotherapy is more effective than systemic chemotherapy for treating advanced ovarian cancer, but is typically associated with severe complications due to high dose, frequent administration schedule, and use of non-biocompatible excipients/delivery vehicles. Here, we developed paclitaxel (PTX)-loaded microspheres composed of di-block copolymers of poly(ethylene glycol) and poly(sebacic acid) (PEG-PSA) for safe and sustained IP chemotherapy. PEG-PSA microspheres provided efficient loading (∼13 % w/w) and prolonged release (∼13 days) of PTX. In a murine ovarian cancer model, a single dose of IP PTX/PEG-PSA particles effectively suppressed tumor growth for more than 40 days and extended the median survival time to 75 days compared to treatments with Taxol® (47 days) or IP placebo particles (34 days). IP PTX/PEG-PSA was well tolerated with only minimal to mild inflammation. Our findings support PTX/PEG-PSA microspheres as a promising drug delivery platform for IP therapy of ovarian cancer and potentially other metastatic peritoneal cancers

Preclinical single photon emission computed tomography of alpha particle-emitting radium-223

Objective: Dose optimization and pharmacokinetic evaluation of α-particle emitting radium-223 dichloride (223RaCl2) by planar γ-camera or single photon emission computed tomography (SPECT) imaging are hampered by the low photon abundance and injected activities. In this study, we demonstrate SPECT of 223Ra using phantoms and small animal in vivo models. Methods: Line phantoms and mice bearing 223Ra were imaged using a dedicated small animal SPECT by detecting the low-energy photon emissions from 223Ra. Localization of the therapeutic agent was verified by whole-body and whole-limb autoradiography and its radiobiological effect confirmed by immunofluorescence. Results: A state-of-the-art commercial small animal SPECT system equipped with a highly sensitive collimator enables collection of sufficient counts for three-dimensional reconstruction at reasonable administered activities and acquisition times. Line sources of 223Ra in both air and in a water scattering phantom gave a line spread function with a full-width-at-half-maximum of 1.45 mm. Early and late-phase imaging of the pharmacokinetics of the radiopharmaceutical were captured. Uptake at sites of active bone remodeling was correlated with DNA damage from the α particle emissions. Conclusions: This work demonstrates the capability to noninvasively define the distribution of 223RaCl2, a recently approved α-particle-emitting radionuclide. This approach allows quantitative assessment of 223Ra distribution and may assist radiation-dose optimization strategies to improve therapeutic response and ultimately to enable personalized treatment planning

Figuring Out Gas & Galaxies In Enzo (FOGGIE). IV. The Stochasticity of Ram Pressure Stripping in Galactic Halos

We study ram pressure stripping in simulated Milky Way-like halos at z>=2 from the Figuring Out Gas & Galaxies In Enzo (FOGGIE) project. These simulations reach exquisite resolution in their circumgalactic medium (CGM) gas owing to FOGGIE's novel refinement scheme. The CGM of each halo spans a wide dynamic range in density and velocity over its volume---roughly 6 dex and 1000 km/s, respectively---translating into a 5 dex range in ram pressure imparted to interacting satellites. The ram pressure profiles of the simulated CGM are highly stochastic, owing to kpc-scale variations of the density and velocity fields of the CGM gas. As a result, the efficacy of ram pressure stripping depends strongly on the specific path a satellite takes through the CGM. The ram-pressure history of a single satellite is generally unpredictable and not well correlated with its approach vector with respect to the host galaxy. The cumulative impact of ram pressure on the simulated satellites is dominated by only a few short strong impulses---on average, 90% of the total surface momentum gained through ram pressure is imparted in 20% or less of the total orbital time. These results reveal an erratic mode of ram pressure stripping in Milky-Way like halos at high redshift---one that is not captured by a smooth spherically-averaged model of the circumgalactic medium.Comment: 18 pages, 10 figures. Submitted to Ap

Imposed identities and limited opportunities: Advocacy agency staff perspectives on the construction of their clients with intellectual disabilities

Intellectual disability is commonly conceptualised as stigmatised identity; however, within the literature, the notion of a damaged identity is contested. The aim of this research was to explore the social construction of intellectual disability from the perspective of staff who work closely with people with intellectual disabilities. Informed by a contextualist perspective, this research was based on interviews with five staff members of an advocacy agency in a regional area of Australia. Causal layered analysis was used to deconstruct the interview data. Analysis of the interactions that emerged across the causal layers revealed a complex dynamic of world views, which served to dehumanise people with intellectual disabilities and blame them for their own fate (victim blaming). For transformative change to occur, understandings of the 'problems' of intellectual disability must be reformulated and those social structures and processes that support the relationship between the powerful and the powerless must be challenged

Validation of Computationally Efficient Simulations of Douglas Fir Pyrolysis and Combustion Using Time-Resolved Frequency Comb Laser Measurements

Computational simulations have the potential to provide low-cost, low-risk insights into wildland fire structure and dynamics. Simulation accuracy is limited, however, by the difficulty of modeling physical processes that span a wide range of spatial scales. These processes include heat transfer via radiation and turbulent advection, as well as both solid- and gas-phase chemistry. In the present study, we perform large eddy simulation (LES) with adaptive mesh refinement to model the multi-phase pyrolysis and combustion of dry Douglas fir, where temperature-based lookup tables corresponding to a multi-step pyrolysis mechanism are used to represent the composition of gas-phase pyrolysis products. Gas-phase and surface temperatures, mass loss, and water vapor mole fraction from the LES are shown to compare favorably with experimental measurements of a radiatively heated Douglas fir fuel sample undergoing pyrolysis and combustion beneath a cone calorimeter. Using frequency comb laser diagnostics, optical and infrared cameras, and a load cell, the experiments provide simultaneous in situ, time-resolved measurements of chemical composition, temperature, and mass loss. The present study thus combines cutting edge computational and experimental techniques with multi-step chemical pyrolysis modeling to provide a validated computational tool for the prediction of solid fuel pyrolysis and combustion relevant to wildland fires. &nbsp;</p

Silver(I) and mercury(II) complexes of meta- and para-xylyl linked bis(imidazol-2-ylidenes)

Mononuclear silver and mercury complexes bearing bis-N-heterocyclic carbene (NHC) ligands withlinear coordination modes have been prepared and structurally characterised. The complexes form metallocyclic structures that display rigid solution behaviour. A larger metallocycle of the form [L2Ag2]2+ [where L = parabis(N-methylimidazolylidene)xylylene] has been isolated from the reaction of para-xylylene-bis(N-methylimidazolium) chloride and Ag2O. Reaction of silver- and mercury-NHC complexes with Pd(NCCH3)2Cl2 affords palladium-NHC complexes via NHC-transfer reactions, the mercury case being only the second example of a NHC-transfer reaction using a mercury-NHC complex

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin