1,806 research outputs found
Current Algebra and Conformal Field Theory on a Figure Eight
We examine the dynamics of a free massless scalar field on a figure eight
network. Upon requiring the scalar field to have a well defined value at the
junction of the network, it is seen that the conserved currents of the theory
satisfy Kirchhoff's law, that is that the current flowing into the junction
equals the current flowing out. We obtain the corresponding current algebra and
show that, unlike on a circle, the left- and right-moving currents on the
figure eight do not in general commute in quantum theory. Since a free scalar
field theory on a one dimensional spatial manifold exhibits conformal symmetry,
it is natural to ask whether an analogous symmetry can be defined for the
figure eight. We find that, unlike in the case of a manifold, the action plus
boundary conditions for the network are not invariant under separate conformal
transformations associated with left- and right-movers. Instead, the system is,
at best, invariant under only a single set of transformations. Its conserved
current is also found to satisfy Kirchhoff's law at the junction. We obtain the
associated conserved charges, and show that they generate a Virasoro algebra.
Its conformal anomaly (central charge) is computed for special values of the
parameters characterizing the network.Comment: 39 pages; Latex with 1 figure included in encapsulated postscript
format. psbox.tex require
Determination of the s-wave Scattering Length of Chromium
We have measured the deca-triplet s-wave scattering length of the bosonic
chromium isotopes Cr and Cr. From the time constants for
cross-dimensional thermalization in atomic samples we have determined the
magnitudes and ,
where . By measuring the rethermalization rate of Cr over a
wide temperature range and comparing the temperature dependence with the
effective-range theory and single-channel calculations, we have obtained strong
evidence that the sign of is positive. Rescaling our Cr
model potential to Cr strongly suggests that is positive,
too.Comment: v3: corrected typo in y-axis scaling of Figs. 3 and
Observation of Feshbach resonances in an ultracold gas of Cr
We have observed Feshbach resonances in elastic collisions between ultracold
Cr atoms. This is the first observation of collisional Feshbach
resonances in an atomic species with more than one valence electron. The zero
nuclear spin of Cr and thus the absence of a Fermi-contact interaction
leads to regularly-spaced resonance sequences. By comparing resonance positions
with multi-channel scattering calculations we determine the s-wave scattering
length of the lowest potentials to be
\unit[112(14)]{a_0}, \unit[58(6)]{a_0} and -\unit[7(20)]{a_0} for S=6, 4,
and 2, respectively, where a_{0}=\unit[0.0529]{nm}.Comment: 4 pages, 2 figures, 1 tabl
Precise determination of Li cold collision parameters by radio-frequency spectroscopy on weakly bound molecules
We employ radio-frequency spectroscopy on weakly bound Li molecules
to precisely determine the molecular binding energies and the energy splittings
between molecular states for different magnetic fields. These measurements
allow us to extract the interaction parameters of ultracold Li atoms based
on a multi-channel quantum scattering model. We determine the singlet and
triplet scattering lengths to be and (1
= 0.0529177 nm), and the positions of the broad Feshbach resonances in
the energetically lowest three wave scattering channels to be 83.41(15) mT,
69.04(5) mT, and 81.12(10) mT
Multichannel quantum-defect theory for ultracold atom-ion collisions
We develop an analytical model for ultracold atom-ion collisions using the
multichannel quantum-defect formalism. The model is based on the analytical
solutions of the r^-4 long-range potential and on the application of a frame
transformation between asymptotic and molecular bases. This approach allows the
description of the atom-ion interaction in the ultracold domain in terms of
three parameters only: the singlet and triplet scattering lengths, assumed to
be independent of the relative motion angular momentum, and the lead dispersion
coefficient of the asymptotic potential. We also introduce corrections to the
scattering lengths that improve the accuracy of our quantum-defect model for
higher order partial waves, a particularly important result for an accurate
description of shape and Feshbach resonances at finite temperature. The theory
is applied to the system composed of a 40Ca+ ion and a Na atom, and compared to
numerical coupled-channel calculations carried out using ab initio potentials.
For this particular system, we investigate the spectrum of bound states, the
rate of charge-transfer processes, and the collision rates in the presence of
magnetic Feshbach resonances at zero and finite temperature.Comment: 39 pages, 21 figure
New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are unacceptable considering that CRC could be successfully treated if diagnosed in the early stages. A high-fat diet promotes the hepatic synthesis of bile acids (BAs) increasing their delivery to the colonic lumen and numerous scientific reports correlate BAs, especially secondary BAs, with CRC incidence. We reviewed the physicochemical and biological characteristics of BAs, focusing on the major pathways involved in CRC risk and progression. We specifically pointed out the role of BAs as signaling molecules and the tangled relationships among their nuclear and membrane receptors with the big bang of molecular and cellular events that trigger CRC occurrence
On the occurrence of cyanolipids in Paullinia carpopodea Cambess and P. cupana Kunth seed oils.
Treatment with PCSK9 Inhibitor Evolocumab Improves Vascular Oxidative Stress and Arterial Stiffness in Hypercholesterolemic Patients with High Cardiovascular Risk
Atherosclerosis and atherosclerotic-related cardiovascular diseases (ASCVD) are characterized by high serum levels of low-density lipoprotein cholesterol (LDL-C) that can promote the generation of reactive oxygen species (ROS). To answer the need for better LDL-C control in individuals at high and very high risk for CVD, a new injectable innovative family of lipid-lowering (LL) monoclonal antibodies against the protein convertase subtilisin/kexin type 9 (PCSK9) has been approved. However, the effect of these drugs on vascular function, such as ROS generation and arterial stiffness, has not already been extensively described. In this report, we present data from 18 males with high to very high CV risk undergoing LL treatment (LLT) with either statin and ezetimibe or ezetimibe monotherapy, who experienced, after a 2-month treatment with Evolocumab, a significant improvement in blood pressure (BP)-adjusted carotid-femoral pulse wave velocity (cfPWV) (p-value = 0.0005 in the whole cohort, p-value = 0.0046 in the sub-cohort undergoing background LLT with statin and ezetimibe, p-value = 0.015 in the sub-cohort undergoing background LLT with ezetimibe monotherapy), which was significantly associated with a decrease in freshly isolated leukocytes (PBMCS)-derived H2O2 production (p-value = 0.004, p-value = 0.02 and p-value = 0.05, respectively, in the whole cohort, in the statin + ezetimibe sub-cohort, and the ezetimibe sub-cohort). Our observations support the role of systemic oxidative stress in atherosclerosis and give a further rationale for using Evolocumab also for its effect in vascular disorders linked to oxidative processes
Eriophyid mites in classical biological control of weeds: Progress and challenges
A classical biological control agent is an exotic host-specific natural enemy, which is intentionally introduced to obtain long-term control of an alien invasive species. Among the arthropods considered for this role, eriophyid mites are likely to possess the main attributes required: Host specificity, efficacy, and long-lasting effects. However, so far, only a few species have been approved for release. Due to their microscopic size and the general lack of knowledge regarding their biology and behavior, working with eriophyids is particularly challenging. Furthermore, mites disperse in wind, and little is known about biotic and abiotic constraints to their population growth. All these aspects pose challenges that, if not properly dealt with, can make it particularly difficult to evaluate eriophyids as prospective biological control agents and jeopardize the general success of control programs. We identified some of the critical aspects of working with eriophyids in classical biological control of weeds and focused on how they have been or may be addressed. In particular, we analyzed the importance of accurate mite identification, the difficulties faced in the evaluation of their host specificity, risk assessment of nontarget species, their impact on the weed, and the final steps of mite release and post-release monitoring
Prescriptive adherence to GINA guidelines and asthma control: An Italian cross sectional study in general practice
Background: Although general practitioners (GPs) are frequently the first healthcare professionals whom asthma patients refer to for their symptoms, few studies have explored the extent of adherence to guidelines for asthma management based on data provided directly by GPs. Aims of the present study were to assess drug prescriptions for asthma by GPs and to evaluate prescriptive adherence to GINA guidelines (GL) and its relationship with disease control in real life. Methods: 995 asthmatic patients (45% males, mean age 43.3 ± 17.7 yrs) were enrolled by 107 Italian GPs distributed throughout the country. Data on diagnosis, disease severity, prescribed anti-asthmatic drugs and control were collected through questionnaires filled out by GPs taking into consideration the 2009 GINA Guidelines. Data on drug use and chronic sinusitis, nasal polyposis, chronic bronchitis, emphysema were reported by patients through a self-administered questionnaire. Results: The large majority of patients were classified by GPs as having intermittent (48.4%) or mild persistent asthma (25.3%); 61% had co-morbid allergic rhinitis (AR). The prevalent therapeutic regimen used by patients was a combination of inhaled corticosteroids (ICS) plus long-acting β2-agonists (LABA) (54.1%), even in the intermittent/mild persistent group. ICS as mono-therapy or in combination with other drugs but LABA, was the second most frequently adopted treatment (14.4%). In general, the GPs adherence to GL treatment indications was 28.8%, with a significant association with a good asthma control (OR 1.85, 95% CI 1.18–2.92). On the other hand, comorbidity (OR 0.52, 95% CI 0.32–0.84), moderate (0.44, 0.28–0.69) and severe (0.06, 0.02–0.20) persistent asthma showed significant negative effects on asthma control. Conclusions: Our results show that over-treatment of intermittent/mild persistent asthma is frequent in the GPs setting while therapeutic regimens are more appropriately applied for moderate/severe asthma. In general, we found low adherence to GINA GL treatment recommendations even if its relevance in asthma control was confirmed
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