Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys.

These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody. Synthesis of (64)Cu-CD45 and (89)Zr-CD45 immunoconjugates was performed and the evaluation of the potential toxicity of radiolabeling human peripheral blood stem cells (hPBSC) was assessed in vitro (viability, population doubling times, colony forming units). hPBSC viability was maintained as the dose of (64)Cu-TETA-CD45 increased from 0 (92%) to 160 µCi/mL (76%, p>0.05). Radiolabeling efficiency was not significantly increased with concentrations of (64)Cu-TETA-CD45 >20 µCi/mL (p>0.50). Toxicity affecting both growth and colony formation was observed with hPBSC radiolabeled with ≥40 µCi/mL (p<0.05). For (89)Zr, there were no significant differences in viability (p>0.05), and a trend towards increased radiolabeling efficiency was noted as the dose of (89)Zr-Df-CD45 increased, with a greater level of radiolabeling with 160 µCi/mL compared to 0-40 µCi/mL (p<0.05). A greater than 2,000 fold-increase in the level of (89)Zr-Df-CD45 labeling efficiency was observed when compared to (64)Cu-TETA-CD45. Similar to (64)Cu-TETA-CD45, toxicity was noted when hPBSC were radiolabeled with ≥40 µCi/mL (p<0.05) (growth, colony formation). Taken together, 20 µCi/mL resulted in the highest level of radiolabeling efficiency without altering cell function. Young rhesus monkeys that had been transplanted prenatally with 25×10(6) hPBSC expressing firefly luciferase were assessed with bioluminescence imaging (BLI), then 0.3 mCi of (89)Zr-Df-CD45, which showed the best radiolabeling efficiency, was injected intravenously for PET imaging. Results suggest that (89)Zr-Df-CD45 was able to identify engrafted hPBSC in the same locations identified by BLI, although the background was high

Longitudinal Spin Asymmetry and Cross Section of Inclusive pi0 Production in Polarized p+p Collisions at RHIC

We present the first measurement of the cross section and the double longitudinal spin asymmetry of inclusive pi0 production in polarized p+p collisions at Sqrt(s) = 200 GeV at mid-rapidity with the STAR detector, using the barrel electromagnetic calorimeter. The measured cross section is compared to NLO pQCD calculations and can provide constraints on the pion fragmentation functions. Fragmentation is studied directly by measuring the momentum fraction of pi0 in jets, a quantity that is affected by the fragmentation process and jet reconstruction effects. The double longitudinal spin asymmetry is compared to NLO pQCD calculations based on different assumptions for the gluon polarization in the nucleon to provide constraints on delta g/g. At the present level of statistics the measured asymmetry disfavors a large positive gluon polarization, but can not yet distinguish between other scenarios.Comment: 4 pages, 2 figures, submitted to the proceedings of the 17th International Spin Physics Symposium (SPIN2006), Kyoto, Japan, October 2 to 7, 200

An Integrated Tracker for STAR

The STAR experiment at the Relativistic Heavy Ion Collider RHIC studies the new state of matter produced in relativistic heavy ion collisions and the spin structure of the nucleon in collisions of polarized protons. In order to improve the capabilities for heavy flavor measurements and the reconstruction of charged vector bosons an upgrade of the tracking system both in the central and the forward region is pursued. The integrated system providing high resolution tracking and secondary vertex reconstruction capabilities will use silicon pixel, strip and GEM technology.Comment: 4 pages, 2 figures, to be published in the Proceedings of the 9th Conference on the Intersections of Particle and Nuclear Physics (CIPANP 2006), Rio Grande, Puerto Rico, May 30 - June 3, 200

Inclusive Hadron Production in p+p Collisions at STAR

The STAR experiment at RHIC has measured a variety of inclusive hadron cross sections in $p+p$ collisions at Sqrt(s) = 200 GeV. Measurements of the differential cross section for inclusive charged pion production at mid rapidity and for inclusive neutral pion production at forward rapidity (3.0 < eta < 4.2) as well as the first preliminary result from STAR for the differential cross section for inclusive neutral pion production near mid rapidity are presented. These cross sections are compared to next-to-leading order perturbative QCD calculations and can provide constraints on the pion fragmentation functions. Good agreement between data and pQCD has been found for all three cross sections.Comment: 4 pages, 1 figure, to be published in the Proceedings of the 9th Conference on the Intersections of Particle and Nuclear Physics (CIPANP 2006), Rio Grande, Puerto Rico, May 30 - June 3, 2006, v2 with updated reference

Nuclear spin ferromagnetic phase transition in an interacting 2D electron gas

Electrons in a two-dimensional semiconducting heterostructure interact with nuclear spins via the hyperfine interaction. Using a a Kondo lattice formulation of the electron-nuclear spin interaction, we show that the nuclear spin system within an interacting two-dimensional electron gas undergoes a ferromagnetic phase transition at finite temperatures. We find that electron-electron interactions and non-Fermi liquid behavior substantially enhance the nuclear spin Curie temperature into the $mK$ range with decreasing electron density.Comment: 4.1 page

Universality properties of the stationary states in the one-dimensional coagulation-diffusion model with external particle input

We investigate with the help of analytical and numerical methods the reaction A+A->A on a one-dimensional lattice opened at one end and with an input of particles at the other end. We show that if the diffusion rates to the left and to the right are equal, for large x, the particle concentration c(x) behaves like As/x (x measures the distance to the input end). If the diffusion rate in the direction pointing away from the source is larger than the one corresponding to the opposite direction the particle concentration behaves like Aa/sqrt(x). The constants As and Aa are independent of the input and the two coagulation rates. The universality of Aa comes as a surprise since in the asymmetric case the system has a massive spectrum.Comment: 27 pages, LaTeX, including three postscript figures, to appear in J. Stat. Phy