Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

Electrical stimulation to affect localised and controlled release of therapeutic drugs is becoming an attractive option in the treatment of acute diseases or chronic illnesses. Currently the materials developed for this technique rely on power sources to operate, making their progression from the laboratory to the biomedical marketplace problematic. To help alleviate this issue, we have demonstrated autonomously powered controlled release of a drug by exploiting the galvanic couple between biodegradable Mg alloy and a conducting organic polymer. We also demonstrate the ability to control the rate of drug release by utilizing a range of biodegradable polymer coatings on the Mg alloy. Combination of the biodegradable Mg and conducting polymer provides a biocompatible platform for the autonomously controlled release of a drug at therapeutic levels

Facile synthesis of reduced graphene oxide/MWNTs nanocomposite supercapacitor materials tested as electrophoretically deposited films on glassy carbon electrodes

This paper reports on a facile synthesis method for reduced graphene oxide (rGO)/multi-walled carbon nanotubes (MWNTs) nanocomposites. The initial step involves the use of graphene oxide to disperse the MWNTs, with subsequent reduction of the resultant graphene oxide/MWNTs composites using l-ascorbic acid (LAA) as a mild reductant. Reduction by LAA preserves the interaction between the rGO sheets and MWNTs. The dispersion-containing rGO/MWNTs composites was characterized and electrophoretically deposited anodically onto glassy carbon electrodes to form high surface area films for capacitance testing. Pseudo capacitance peaks were observed in the rGO/MWNTs composite electrodes, resulting in superior performance with capacitance values up to 134.3 F g−1 recorded. This capacitance value is higher than those observed for LAA-reduced GO (LAA-rGO) (63.5 F g−1), electrochemically reduced GO (EC-rGO) (27.6 F g−1), or electrochemically reduced GO/MWNTs (EC-rGO/MWNTs) (98.4 F g−1)-based electrodes

Gastroenterology research and practice

New insights into electrochemical kinetics of the flavin adenine dinucleotide (FAD) redox center of glucose-oxidase (GlcOx) immobilized on reduced graphene oxide (rGO), single- and multiwalled carbon nanotubes (SW and MWCNT), and combinations of rGO and CNTs have been gained by application of Fourier transformed AC voltammetry (FTACV) and simulations based on a range of models. A satisfactory level of agreement between experiment and theory, and hence establishment of the best model to describe the redox chemistry of FAD, was achieved with the aid of automated e-science tools. Although still not perfect, use of Marcus theory with a very low reorganization energy (≤0.3 eV) best mimics the experimental FTACV data, which suggests that the process is gated as also deduced from analysis of FTACV data obtained at different frequencies. Failure of the simplest models to fully describe the electrode kinetics of the redox center of GlcOx, including those based on the widely employed Laviron theory is demonstrated, as is substantial kinetic heterogeneity of FAD species. Use of a SWCNT support amplifies the kinetic heterogeneity, while a combination of rGO and MWCNT provides a more favorable environment for fast communication between FAD and the electrode

NGTS clusters survey – IV. Search for Dipper stars in the Orion Nebular Cluster

The dipper is a novel class of young stellar object associated with large drops in flux on the order of 10–50 per cent lasting for hours to days. Too significant to arise from intrinsic stellar variability, these flux drops are currently attributed to disc warps, accretion streams, and/or transiting circumstellar dust. Dippers have been previously studied in young star-forming regions, including the Orion Complex. Using Next Generation Transit Survey (NGTS) data, we identified variable stars from their light curves. We then applied a machine learning random forest classifier for the identification of new dipper stars in Orion using previous variable classifications as a training set. We discover 120 new dippers, of which 83 are known members of the Complex. We also investigated the occurrence rate of discs in our targets, again using a machine learning approach. We find that all dippers have discs, and most of these are full discs. We use dipper periodicity and model-derived stellar masses to identify the orbital distance to the inner disc edge for dipper objects, confirming that dipper stars exhibit strongly extended sublimation radii, adding weight to arguments that the inner disc edge is further out than predicted by simple models. Finally, we determine a dipper fraction (the fraction of stars with discs which are dippers) for known members of 27.8 ± 2.9 per cent. Our findings represent the largest population of dippers identified in a single cluster to date

NGTS clusters survey – IV. Search for Dipper stars in the Orion Nebular Cluster

The dipper is a novel class of young stellar object associated with large drops in flux on the order of 10–50 per cent lasting for hours to days. Too significant to arise from intrinsic stellar variability, these flux drops are currently attributed to disc warps, accretion streams, and/or transiting circumstellar dust. Dippers have been previously studied in young star-forming regions, including the Orion Complex. Using Next Generation Transit Survey (NGTS) data, we identified variable stars from their light curves. We then applied a machine learning random forest classifier for the identification of new dipper stars in Orion using previous variable classifications as a training set. We discover 120 new dippers, of which 83 are known members of the Complex. We also investigated the occurrence rate of discs in our targets, again using a machine learning approach. We find that all dippers have discs, and most of these are full discs. We use dipper periodicity and model-derived stellar masses to identify the orbital distance to the inner disc edge for dipper objects, confirming that dipper stars exhibit strongly extended sublimation radii, adding weight to arguments that the inner disc edge is further out than predicted by simple models. Finally, we determine a dipper fraction (the fraction of stars with discs which are dippers) for known members of 27.8 ± 2.9 per cent. Our findings represent the largest population of dippers identified in a single cluster to date.</p