Scoping exercise on fallers’ clinics : report to the National Co-ordinating Centre for NHS Service Delivery and Organisation R & D (NCCSDO)

The National Service Framework for Older People has stated the need for fall-prevention programmes. An appraisal of fallers’ clinics launched by the National Institute for Health and Clinical Excellence (NICE) was suspended because of a lack of information regarding existing services and typology. This project aimed to determine the feasibility of conducting economic modelling to appraise fallers’ clinics. To achieve this a national survey of services and reviews of the evidence of effectiveness of various models of fallers’ clinics and screening tools were undertaken

Non-Universal Quasi-Long Range Order in the Glassy Phase of Impure Superconductors

The structural correlation functions of a weakly disordered Abrikosov lattice are calculated for the first time in a systematic RG-expansion in d=4-\epsilon dimensions. It is shown, that in the asymptotic limit the Abrikosov lattice exhibits still quasi long range translational order described by a non-universal exponent \bar\eta_{\bf G} which depends on the ratio of the renormalized elastic constants \kappa =\tilde c_{66}/\tilde c_{11} of the flux line (FL) lattice. Our calculations show clearly three distinct scaling regimes corresponding to the Larkin, the manifold and the asymptotic Bragg glass regime. On a wide range of intermediate length scales the FL displacement correlation function increases as a power law with twice of the manifold roughness exponent \zeta_{rm}(\kappa), which is also non-universal. Our results, in particular the \kappa-dependence of the exponents, are in variance with those of the variational treatment with replica symmetry breaking which allows in principle an experimental discrimination between the two approaches.Comment: 4 pages, 3 figure

Nonuniversal Correlations and Crossover Effects in the Bragg-Glass Phase of Impure Superconductors

The structural correlation functions of a weakly disordered Abrikosov lattice are calculated in a functional RG-expansion in $d=4-\epsilon$ dimensions. It is shown, that in the asymptotic limit the Abrikosov lattice exhibits still quasi-long-range translational order described by a {\it nonuniversal} exponent $\eta_{\bf G}$ which depends on the ratio of the renormalized elastic constants $\kappa ={c}_{66}/ {c}_{11}$ of the flux line (FL) lattice. Our calculations clearly demonstrate three distinct scaling regimes corresponding to the Larkin, the random manifold and the asymptotic Bragg-glass regime. On a wide range of {\it intermediate} length scales the FL displacement correlation function increases as a power law with twice the manifold roughness exponent $\zeta_{\rm RM}(\kappa)$, which is also {\it nonuniversal}. Correlation functions in the asymptotic regime are calculated in their full anisotropic dependencies and various order parameters are examined. Our results, in particular the $\kappa$-dependency of the exponents, are in variance with those of the variational treatment with replica symmetry breaking which allows in principle an experimental discrimination between the two approaches.Comment: 17 pages, 10 figure

Problems With the Vortex-Boson Mapping in 1+1 Dimensions

Using the well known boson mapping, we relate the transverse magnetic susceptibility of a system of flux vortices in 1+1 dimensions to an appropriately defined conductivity of a one-dimensional boson system. The tilt response for a system free of disorder is calculated directly, and it is found that a subtle order of limits is required to avoid deceptive results.Comment: 4 Pages (REVTeX 3.0). Postscript file for this paper is available on the World Wide Web at http://cmtw.harvard.edu/~simon/

Short-range spin glasses and Random Overlap Structures

Properties of Random Overlap Structures (ROSt)'s constructed from the Edwards-Anderson (EA) Spin Glass model on $\Z^d$ with periodic boundary conditions are studied. ROSt's are $\N\times\N$ random matrices whose entries are the overlaps of spin configurations sampled from the Gibbs measure. Since the ROSt construction is the same for mean-field models (like the Sherrington-Kirkpatrick model) as for short-range ones (like the EA model), the setup is a good common ground to study the effect of dimensionality on the properties of the Gibbs measure. In this spirit, it is shown, using translation invariance, that the ROSt of the EA model possesses a local stability that is stronger than stochastic stability, a property known to hold at almost all temperatures in many spin glass models with Gaussian couplings. This fact is used to prove stochastic stability for the EA spin glass at all temperatures and for a wide range of coupling distributions. On the way, a theorem of Newman and Stein about the pure state decomposition of the EA model is recovered and extended.Comment: 27 page

Dynamics of the Wang-Landau algorithm and complexity of rare events for the three-dimensional bimodal Ising spin glass

We investigate the performance of flat-histogram methods based on a multicanonical ensemble and the Wang-Landau algorithm for the three-dimensional +/- J spin glass by measuring round-trip times in the energy range between the zero-temperature ground state and the state of highest energy. Strong sample-to-sample variations are found for fixed system size and the distribution of round-trip times follows a fat-tailed Frechet extremal value distribution. Rare events in the fat tails of these distributions corresponding to extremely slowly equilibrating spin glass realizations dominate the calculations of statistical averages. While the typical round-trip time scales exponential as expected for this NP-hard problem, we find that the average round-trip time is no longer well-defined for systems with N >= 8^3 spins. We relate the round-trip times for multicanonical sampling to intrinsic properties of the energy landscape and compare with the numerical effort needed by the genetic Cluster-Exact Approximation to calculate the exact ground state energies. For systems with N >= 8^3 spins the simulation of these rare events becomes increasingly hard. For N >= 14^3 there are samples where the Wang-Landau algorithm fails to find the true ground state within reasonable simulation times. We expect similar behavior for other algorithms based on multicanonical sampling.Comment: 9 pages, 12 figure

Delocalization in Coupled Luttinger Liquids with Impurities

We study effects of quenched disorder on coupled two-dimensional arrays of Luttinger liquids (LL) as a model for stripes in high-T_c compounds. In the framework of a renormalization-group analysis, we find that weak inter-LL charge-density-wave couplings are always irrelevant as opposed to the pure system. By varying either disorder strength, intra- or inter-LL interactions, the system can undergo a delocalization transition between an insulator and a novel strongly anisotropic metallic state with LL-like transport. This state is characterized by short-ranged charge-density-wave order, the superconducting order is quasi long-ranged along the stripes and short-ranged in the transversal direction.Comment: 6 pages, 5 figures, substantially extended and revised versio

The perception and management of risk in UK office property development

Risk is an ever-present aspect of business, and risk taking is necessary for profit and economic progress. Speculative property development is popularly perceived as a 'risky business' yet, like other entrepreneurs, developers have opportunities to manage the risks they face; techniques include phasing and joint ventures. The associated areas of investment portfolio risk, development risk analysis and construction risk management have all been addressed by research. This article presents new knowledge about how developers perceive risks and the means they subsequently adopt to manage them. The developers of office projects across the UK were sent questionnaires by post. Respondents were asked about their perceptions of risks at the first appraisal stage and currently and about the risk management techniques that they had adopted. In-depth interviews with a selection of respondents were then used to discuss and augment the findings. Developers were most concerned about market-based risks at both stages. Concern about production-orientated risks was lower and fell significantly between the two stages. A fixed price contract was the most common risk management technique. Risk management techniques were used more often outside London and the South East. Developer type affects both the perception and management of risk. While developers do manage risk, decisions are made on the basis of professional and business experience. These findings should help development companies manage risk in a more objective and analytical way

Genome-wide screening for DNA variants associated with reading and language traits

This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills.Publisher PDFPeer reviewe

High Temperature Expansions and Dynamical Systems

We develop a resummed high-temperature expansion for lattice spin systems with long range interactions, in models where the free energy is not, in general, analytic. We establish uniqueness of the Gibbs state and exponential decay of the correlation functions. Then, we apply this expansion to the Perron-Frobenius operator of weakly coupled map lattices.Comment: 33 pages, Latex; [email protected]; [email protected]