1,340 research outputs found
The Uighur Riots in China: What do Facebook groups say?
In July  2009, China witnessed its worst ethnic clashes in decades, excluding those in Tibet, when  protests by Uighurs in Urumqi, capital of the western Xinjiang province, turned violent after police intervention. The protest started after two Uighur workers in the southern district of Guangdong had been killed as a result of racial violence. Soon afterwards, individuals belonging to the majority Han ethnicity, who represent about 92% of the Chinese population, but only 40% of the population of Xinjiang, attacked Uighur targets and individuals. The death toll rose to at least 150 individuals, although the racial breakdown of the deceased is still not quite clear. The government moved quickly to round up suspects and threatened to execute those directly involved in the violent incidents. Hundreds of Uighurs were detained by police
A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies
Joint Contour Net Analysis for Feature Detection in Lattice Quantum Chromodynamics Data
In this paper we demonstrate the use of multivariate topological algorithms
to analyse and interpret Lattice Quantum Chromodynamics (QCD) data. Lattice QCD
is a long established field of theoretical physics research in the pursuit of
understanding the strong nuclear force. Complex computer simulations model
interactions between quarks and gluons to test theories regarding the behaviour
of matter in a range of extreme environments. Data sets are typically generated
using Monte Carlo methods, providing an ensemble of configurations, from which
observable averages must be computed. This presents issues with regard to
visualisation and analysis of the data as a typical ensemble study can generate
hundreds or thousands of unique configurations. We show how multivariate
topological methods, such as the Joint Contour Net, can assist physicists in
the detection and tracking of important features within their data in a
temporal setting. This enables them to focus upon the structure and
distribution of the core observables by identifying them within the surrounding
data. These techniques also demonstrate how quantitative approaches can help
understand the lifetime of objects in a dynamic system.Comment: 30 pages, 19 figures, 4 table
Carbonaceous and nitrogenous disinfection by-product formation from algal organic matter
Seasonal algal blooms in drinking water sources release intracellular and extracellular algal organic matter (AOM) in significant concentrations into the water. This organic matter provides precursors for disinfection by-products (DBPs) formed when the water is subsequently chlorinated at the final disinfection stage of the potable water treatment process. This paper presents results of AOM characterisation from five algal species (three cyanobacteria, one diatom and one green) alongside the measurement of the DBP formation potential from the AOM of six algal species (an additional diatom). The character was explored in terms of hydrophilicity, charge and protein and carbohydrate content. 18 DBPs were measured following chlorination of the AOM samples: the four trihalomethanes (THMs), nine haloacetic acids (HAAs), four haloacetonitriles (HANs) and one halonitromethane (HNM).
The AOM was found to be mainly hydrophilic (52 and 81%) in nature. Yields of up to 92.4 ÎŒg mgâ1 C carbonaceous DBPs were measured, with few consistent trends between DBP formation propensity and either the specific ultraviolet absorbance (SUVA) or the chemical characteristics. The AOM from diatomaceous algae formed significant amounts of nitrogenous DBPs (up to 1.7 ÎŒg mgâ1 C). The weak trends in DBPFP may be attributable to the hydrophilic nature of AOM, which also makes it more challenging to remove by conventional water treatment processes
The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling
Background: T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like LAT or PAG by possessing a substantial ectodomain that binds CD166, a well-characterized ligand expressed on most antigen-presenting cells (APC), through the third domain (d3) of the extracellular region. Although the intact form of CD6 is the most abundant in T cells, an isoform lacking d3 (CD6âd3) is transiently expressed on activated T cells. Still, the precise character of the signaling transduced by CD6, whether costimulatory or inhibitory, and the influence of its ectodomain on these activities are unclear. Methods: We expressed CD6 variants with extracellular deletions or cytosolic mutations in Jurkat cells containing eGFP reporters for NF-ÎșB and NF-AT transcription factor activation. Cell activation was assessed by eGFP flow cytometry following Jurkat cell engagement with superantigen-presenting Raji cells. Using imaging flow cytometry, we evaluated the impact of the CD6-CD166 pair on cell adhesiveness during the antigen-dependent and -independent priming of T cells. We also examined the role of extracellular or cytosolic sequences on CD6 translocation to the immunological synapse, using immunofluorescence-based imaging. Results: Our investigation dissecting the functions of the extracellular and cytosolic regions of CD6 revealed that CD6 was trafficked to the immunological synapse and exerted tonic inhibition wholly dependent on its cytosolic tail. Surprisingly, however, translocation to the synapse occurred independently of the extracellular d3 and of engagement to CD166. On the other hand, CD6 binding to CD166 significantly increased T cell:APC adhesion. However, this activity was most evident in the absence of APC priming with superantigen, and thus, in the absence of TCR engagement. Conclusions: Our study identifies CD6 as a novel âon/offâ scaffold-receptor capable of modulating responsiveness in two ways. Firstly, and independently of ligand binding, it establishes signaling thresholds through tonic inhibition, functioning as a membrane-bound scaffold. Secondly, CD6 has the capacity for alternative splicing-dependent variable ligand engagement, modulating its checkpoint-like activity
The environmental security debate and its significance for climate change
Policymakers, military strategists and academics all increasingly hail climate change as a security issue. This article revisits the (comparatively) long-standing âenvironmental security debateâ and asks what lessons that earlier debate holds for the push towards making climate change a security issue. Two important claims are made. First, the emerging climate security debate is in many ways a re-run of the earlier dispute. It features many of the same proponents and many of the same disagreements. These disagreements concern, amongst other things, the nature of the threat, the referent object of security and the appropriate policy responses. Second, given its many different interpretations, from an environmentalist perspective, securitisation of the climate is not necessarily a positive development
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