791 research outputs found

    The addition of bevacizumab to standard chemotherapy in breast cancer : which patient benefits the most?

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    Bevacizumab, a humanized monoclonal antibody directed against vascular endothelial growth factor, is an effective and well-tolerated treatment option for patients with breast cancer. Bevacizumab has demonstrated a gain in progression-free survival and a trend towards an overall survival benefit in various subgroups of breast cancer. Given the lack of a predictive biomarker, we performed a literature search with regard to efficacy and tolerability of bevacizumab in different subgroups of breast cancer patients and in different settings. In the metastatic setting, the efficacy of bevacizumab has been most extensively studied and demonstrated in patients with triple-negative breast cancer, the most difficult-to-treat population among patients with advanced disease and also the group with the biggest need for new treatment options. Overall, bevacizumab is well tolerated with very few serious adverse events. Bevacizumab is also an active and feasible treatment option for patients above 70 years of age

    PENGARUH PENGGUNAAN OLI SAE 40, OLI 15W- 40 DAN CAMPURAN TERHADAP VISKOSITAS, TEMPERATUR ENGINE DAN EMISI GAS BUANG PADA MOBIL TOYOTA 2KD-FTV

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    Minyak pelumas terdiri dari campuran hidrokarbon dan ditambah zat-zat lain yang disebut aditif. Pada kandungan minyak pelumas terdapat lapisan (oil film), dan memiliki kekentalan yang beragam (viscosity) sesuai dengan yang dibutuhkan engine. Telah dilakukan penelitian viskositas minyak pelumas yaitu sebelum dan sesudah digunakan, temperatur engine dan emisi gas buang. Pada penelitian ini minyak pelumas yang digunakan adalah Meditran SAE 40 dan Castrol GTX 15W- 40. Alat yang digunakan adalah Viskotester VT-01, Akusisi Data Thermal dan Gas Analyzer. Putaran engine yang digunakan untuk pengambilan data Temperatur dan emisi adalah 1000,1500,2000 RPM.  Hasil penelitian yang didapat adalah pada percampuran minyak pelumas Meditran sebesar 50% dan Castrol 50% menunjukkan hasil yang bagus yaitu penurunan kekentalan (viscosity) minyak pelumas yang sedikit, temperatur engine yang mendekati suhu kerja dan rata-rata emisi yang dihasilkan pada setiap rpm menunjukkan nilai yang rendah

    Large-Scale Modeling and Cell-edge Coverage for Future HetNet Deployments

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    Describing SĂŁo Tomense Using a Tree-Adjoining Meta-Grammar

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    Poster sessionInternational audienceIn this paper, we show how the interactions between the tense, aspect and mood preverbal markers in São Tomense can be formally and concisely described at an abstract level, using the concept of projection. More precisely, we show how to encode the different valid orders of preverbal markers in an abstract description of a Tree-Adjoining Grammar of São Tomense. This description is written using the XMG meta-grammar language (Crabbé and Duchier, 2004)

    Décrire la morphologie des verbes en ikota au moyen d'une métagrammaire

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    Association pour le Traitement Automatique des Langues. This article has been published in the Proceedings of the JEP-TALN-RECITAL 2012 conference. Available on-line at https://www.aclweb.org/anthology/W/W12/W12-1309.pdfNational audienceDans cet article, nous montrons comment le concept des mĂ©tagrammaires introduit initialement par Candito (1996) pour la conception de grammaires d'arbres adjoints dĂ©crivant la syntaxe du français et de l'italien, peut ĂȘtre appliquĂ©e Ă  la description de la morphologie de l'ikota, une langue bantoue parlĂ© au Gabon. Ici, nous utilisons l'expressivitĂ© du formalisme XMG (eXtensible MetaGrammar) pour dĂ©crire les variations morphologiques des verbes en ikota. Cette spĂ©cification XMG capture les gĂ©nĂ©ralisations entre ces variations. Afin de produire un lexique de formes flĂ©chies, il est possible de compiler la spĂ©cification XMG, et de sauvegarder le rĂ©sultat dans un fichier XML, ce qui permet sa rĂ©utilisation dans des applications dĂ©diĂ©es
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