Additional file 1: Figure S1. of Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

Hinge incorporation can promote the expansion of CAR T cells. Flow cytometric analysis of the percentage of 19.28z, 19-H.28z T cells, Meso.28z, Meso-H.28z T cells, PSCA.28z, PSCA-H.28z T cells, and GFP control T cells from day 6 to 15 during the in vitro culture period. The data are representative of independent experiments verified with cells from over three individual healthy human donors. (JPG 2876 kb

Additional file 1: Table S1. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Characteristics of the 25 patients. (DOCX 17 kb

Additional file 13: Figure S8. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Single cell assays of primary adult B-ALL cells. (A) Each NSI mouse was injected with a single primary B-ALL cell. Sixteen weeks after transplantation, the BM compartments of hosts were subjected to FACS analysis. (B) Representative FACS analysis of B-ALL cells used for single cell transplantation (Before, left) and gated hCD45+ cells from the BM compartments of the successfully grafted hosts (After, right). (JPG 494 kb