Characteristics of the 25 patients. (DOCX 17 kb

Baiheng Li (3523613)

Bing Xu (69508)

Donghai Wu (309245)

Duanqing Pei (275241)

Gong Zhang (69122)

Haijia Chen (3523598)

Jianyu Weng (3523616)

Manman Deng (3523595)

Peilong Lai (3523610)

Peng Li (69518)

Pentao Liu (31036)

Simiao Lin (3523604)

Suna Wang (578272)

Wei Wei (21173)

Wei Ye (105005)

Xin Du (208780)

Xin Liu (43569)

Xinru Wei (3523601)

Yangqiu Li (1495978)

Yao Yao (335996)

Yiren Xiao (3523607)

Yuguo Ma (1411762)

Zhiwu Jiang (460654)

PubMed

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Additional file 1: Table S1. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Summary of single B-ALL cell xenotransplantation. (DOCX 27 kb

Additional file 14: Table S6. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Â© 2016 The Author(s). The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized.Link_to_subscribed_fulltex

Wei, Xinru

Jiang, Zhiwu

Deng, Manman

Ye, Wei

Xiao, Yiren

Lin, Simiao

Wang, Suna

Li, Baiheng

Liu, Xin

Zhang, Gong

Lai, Peilong

Weng, Jianyu

Wu, Donghai

Chen, Haijia

Wei, Wei

Ma, Yuguo

Li, Yangqiu

Liu, Pentao

Du, Xin

Pei, Duanqing

Yao, Yao

Xu, Bing

Li, Peng

HKU Scholars Hub

Journal of Hematology & Oncology

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Single cell assays of primary adult B-ALL cells. (A) Each NSI mouse was injected with a single primary B-ALL cell. Sixteen weeks after transplantation, the BM compartments of hosts were subjected to FACS analysis. (B) Representative FACS analysis of B-ALL cells used for single cell transplantation (Before, left) and gated hCD45+ cells from the BM compartments of the successfully grafted hosts (After, right). (JPG 494 kb

Additional file 13: Figure S8. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Engrafted mice transplanted with cultured leukemic cells. (DOCX 19 kb

Additional file 11: Table S5. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Abstract The existence and identification of leukemia-initiating cells in adult acute B lymphoblastic leukemia (B-ALL) remain controversial. We examined whether adult B-ALL is hierarchically organized into phenotypically distinct subpopulations of leukemogenic and non-leukemogenic cells or whether most B-ALL cells retain leukemogenic capacity, irrespective of their immunophenotype profiles. Our results suggest that adult B-ALL follows the stochastic stem cell model and that the expression of CD34 and CD38 in B-ALL is reversibly and not hierarchically organized

Additional file 1: Table S1. of Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

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