Toksyczna nekroliza naskórka wikłająca antybiotykoterapię połogowego zapalenia endometrium: opis przypadku

The aim of the study is to describe a case report of Lyell syndrome (toxic epidermal necrolysis) involving 63% of body surface which has been associated with antibiotic therapy of mild peurperal endometritis in woman 3 weeks postpartum. Lyell syndrome is a severe life-threatening condition developing due to idiosyncrazy (alergic reaction type IV), most commonly after administration of drugs. Incidence quoted in literature is around 1:1-2000000. Illness severity can be assessed using a SCORTEN scoring system, which predicts patient mortality based on seven independent factors. Lyell syndrome is a very rare but potentially lethal complication of antibiotic treatment.Celem pracy jest opis przypadku zespołu Lyell’a (toksyczna nekroliza naskórka) obejmująca 63% powierzchni ciała, który był związany z antybiotykoterapią łagodnego zapalenia endometrium u kobiety 3 tygodnie po porodzie. Zespół Lyell’a jest ciężkim zagrażającym życiu stanem wywołanym idiosynkrazją (reakcja alergiczna typu IV), najczęściej po podaniu leków. Częstość występowania szacowana jest na około 1:1-2000000. Ciężkość choroby może być określona przy pomocy systemu punktowego SCORTEN, który przewiduje ryzyko zgonu pacjenta w oparciu o siedem niezależnych czynników. Zespół Lyell’a jest bardzo rzadkim ale potencjalnie śmiertelnym powikłaniem antybiotykoterapii

Optimisation of the DQM software

The Data Quality Monitoring (DQM) Software proved to be a central tool in the CMS experiment. Its flexibility allowed its integration in several environments: Online, for real-time detector monitoring; Offline, for the final, fine-grained Data Certification; Release Validation, to constantly validate the functionality and the performance of the reconstruction soft- ware; in Monte Carlo productions [1, 2, 3]. The resources used by the different DQM software systems, both in terms of time and memory, are ever-growing. Having in mind the next to come LHC phases, the improvement of the perfor- mance of the DQM and Validation code will make possible the validation of extreme condition scenarios (events with high number of pileup vertices)

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

26 septembre 19421942/09/26 (A43,N15230)-1942/09/27

Dosimetric comparison of MRI-based HDR brachytherapy and stereotactic radiotherapy in patients with advanced cervical cancer: A virtual brachytherapy study

AimTo evaluate the treatment plans of 3D image-guided brachytherapy (BT) and stereotactic robotic radiotherapy with online image guidance – CyberKnife (CK) in patients with locally advanced cervix cancer.Methods and materialsTen pairs of plans for patients with locally advanced inoperable cervical cancer were created using MR based 3D brachytherapy and stereotaxis CK. The dose that covers 98% of the target volume (HR CTV D98) was taken as a reference and other parameters were compared.ResultsOf the ten studied cases, the dose from D100 GTV was comparable for both devices, on average, the BT GTV D90 was 10–20% higher than for CK. The HR CTV D90 was higher for CK with an average difference of 10–20%, but only fifteen percent of HR CTV (the peripheral part) received a higher dose from CK, while 85% of the target volume received higher doses from BT. We found a significant organ-sparing effect of CK compared to brachytherapy (20–30% lower doses in 0.1[[ce:hsp sp="0.25"/]]cm3, 1[[ce:hsp sp="0.25"/]]cm3, and 2[[ce:hsp sp="0.25"/]]cm3).ConclusionBT remains to be the best method for dose escalation. Due to the significant organ-sparing effect of CK, patients that are not candidates for BT could benefit from stereotaxis more than from classical external beam radiotherapy

CERN Accelerators Topology Configuration: Facing the Next Long Shutdown

The Configuration and Layout (CL) team at CERN ensures that there is a clear and coherent representation of the status of the CERN underground facilities (about 60 km of equipment) and main accelerator projects at a given point in time. In view of the major equipment changes to be carried out during the extended end of year technical stop (EYETS), the next Long Shutdown (LS2), and to facilitate the associated preparatory work of multiple CERN groups, the CL team has developed an immersive visualisation tool, displaying 360 degree panoramic images of CERN underground facilities. In addition, the CL team is launching a process to manage future layout configurations inside the CERN Layout database in parallel to the current configuration. This paper presents the 360 degree panorama visualisation tool and the parallel configuration process, to view the past, current and future status of the CERN accelerator complex. It highlights their added value for the CERN groups in the preparatory phase for upgrade and consolidation modifications and discusses the potential future improvements

Maternal WBC counts stratified according to the presence or absence of both MIAC and IAI.

<p>A receiver-operating characteristic curve for the presence of both MIAC and IAI is shown (the area under the curve is 0.70 for the WBC cutoff value of >14.0 × 10⁹/L; <i>p</i> < 0.0001). Abbreviations: WBC, white blood cell count; MIAC, microbial invasion of the amniotic cavity; IAI, intra-amniotic inflammation.</p

Cervical Gardnerella vaginalis in women with preterm prelabor rupture of membranes.

ObjectiveTo determine the association between microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) and the cervical prevalence of Gardnerella vaginalis DNA in pregnancies with preterm prelabor rupture of membrane (PPROM).MethodIn total, 405 women with singleton pregnancies complicated with PPROM were included. Cervical fluid and amniotic fluid samples were collected at the time of admission. Bacterial and G. vaginalis DNA were assessed in the cervical fluid samples using quantitative PCR technique. Concentrations of interleukin-6 and MIAC were evaluated in the amniotic fluid samples. Loads of G. vaginalis DNA ≥ 1% of the total cervical bacterial DNA were used to define the cervical prevalence of G. vaginalis as abundant. Based on the MIAC and IAI, women were categorized into four groups: with intra-amniotic infection (both MIAC and IAI), with sterile IAI (IAI without MIAC), with MIAC without IAI, and without either MIAC or IAI.ResultsThe presence of the abundant cervical G. vaginalis was related to MIAC (with: 65% vs. without: 44%; p = 0.0004) but not IAI (with: 52% vs. without: 48%; p = 0.70). Women with MIAC without IAI had the highest load of the cervical G. vaginalis DNA (median 2.0 × 104 copies DNA/mL) and the highest presence of abundant cervical G. vaginalis (73%).ConclusionsIn women with PPROM, the presence of cervical G. vaginalis was associated with MIAC, mainly without the concurrent presence of IAI