Environmental Assessment for Ocean Energy Schemes: Useful Tools and Case Studies

This work concerns a review of the state of the art of current and practical experience on environmental assessment (including monitoring) in order to set the path to be followed for future ocean energy schemes. It includes a revision of the work done so far in some test sites and deployment sites and discusses the use of several tools considering project phases (installation, deployment and decommissioning) and environmental impact assessment steps (screening, scoping, baseline studies for reference condition characterization, impact identification and evaluation, mitigation measures and monitoring). Within the list of such tools the applicability of checklists, matrices, mathematical modelling, Geographic Information Systems are considered as well as other shared and integrative methods: Environmental Risk Assessment and Life Cycle Analysis

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two demonstrating sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of further common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signalling and cell cycle regulation, in diabetes pathogenesis

Environmental Assessment for Ocean Energy Schemes: Useful Tools and Case Studies

This work concerns a review of the state of the art of current and practical experience on environmental assessment (including monitoring) in order to set the path to be followed for future ocean energy schemes. It includes a revision of the work done so far in some test sites and deployment sites and discusses the use of several tools considering project phases (installation, deployment and decommissioning) and environmental impact assessment steps (screening, scoping, baseline studies for reference condition characterization, impact identification and evaluation, mitigation measures and monitoring). Within the list of such tools the applicability of checklists, matrices, mathematical modelling, Geographic Information Systems are considered as well as other shared and integrative methods: Environmental Risk Assessment and Life Cycle Analysis

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis