Modern features of the anamnesis of patients from preeklampsia varying severity : Современные особенности анамнеза пациенток с преэклампсией различной степени тяжести

Objective of this research was studying of modern risk factors on development of a preeklampsia of vary-ing severity on the basis of the anamnesis of patients. Results of the conducted research showed that the preeklampsia most often develops at first pregnant woman "fertile" age, brainwork, with the burdened heredity and the somatic anamnesis, inflammatory diseases of a female genital and violation of a men-strual cycle. Among the burdening factors is heredity and the somatic anamnesis it is necessary to carry diseases of vascular and kidney genesis and an endokrinopatiya (pyelonephritis, a hypertensive illness, violation of a fatty exchange

CCGT-CHP WITH A REDUCED CARBON FOOTPRINT

The issues of creating energy-efficient and environmentally friendly energy generation technologies based on fossil fuel, solid based waste is considered. A comprehensive technol-ogy has been proposed to utilize regional industrial waste together with the Thermal Power Plant CO2 emissions

Modern features of the anamnesis of patients from preeklampsia varying severity : Современные особенности анамнеза пациенток с преэклампсией различной степени тяжести

Objective of this research was studying of modern risk factors on development of a preeklampsia of vary-ing severity on the basis of the anamnesis of patients. Results of the conducted research showed that the preeklampsia most often develops at first pregnant woman "fertile" age, brainwork, with the burdened heredity and the somatic anamnesis, inflammatory diseases of a female genital and violation of a men-strual cycle. Among the burdening factors is heredity and the somatic anamnesis it is necessary to carry diseases of vascular and kidney genesis and an endokrinopatiya (pyelonephritis, a hypertensive illness, violation of a fatty exchange

The Flatworm Macrostomum lignano Is a Powerful Model Organism for Ion Channel and Stem Cell Research

Bioelectrical signals generated by ion channels play crucial roles in many cellular processes in both excitable and nonexcitable cells. Some ion channels are directly implemented in chemical signaling pathways, the others are involved in regulation of cytoplasmic or vesicular ion concentrations, pH, cell volume, and membrane potentials. Together with ion transporters and gap junction complexes, ion channels form steady-state voltage gradients across the cell membranes in nonexcitable cells. These membrane potentials are involved in regulation of such processes as migration guidance, cell proliferation, and body axis patterning during development and regeneration. While the importance of membrane potential in stem cell maintenance, proliferation, and differentiation is evident, the mechanisms of this bioelectric control of stem cell activity are still not well understood, and the role of specific ion channels in these processes remains unclear. Here we introduce the flatworm Macrostomum lignano as a versatile model organism for addressing these topics. We discuss biological and experimental properties of M. lignano, provide an overview of the recently developed experimental tools for this animal model, and demonstrate how manipulation of membrane potential influences regeneration in M. lignano

Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration

International audienceThe Rac1-WAVE-Arp2/3 pathway pushes the plasma membrane by polymerizing branched actin, thereby powering membrane protrusions that mediate cell migration. Here, using knock-down (KD) or knock-out (KO), we combine the inactivation of the Arp2/3 inhibitory protein Arpin, the Arp2/3 subunit ARPC1A and the WAVE complex subunit, CYFIP2, that all enhance the polymerization of cortical branched actin (CBA). Inactivation of the 3 CBA negative regulators increases migration persistence of human breast MCF10A cells, and of endodermal cells in the zebrafish embryo, significantly more than any single or double inactivation. In the triple KO, but not triple KD cells, the “super-migrator” phenotype was associated with a heterogenous down-regulation of vimentin expression and a lack of coordination in collective behaviors, such as wound healing and acinus morphogenesis. Re-expression of vimentin in triple KO cells restored to a large extent normal persistence of single cell migration, suggesting that vimentin down-regulation contributes to the maintenance of the super-migrator phenotype in triple KO cells. Constant excessive production of branched actin at the cell cortex thus commits cells into a motile state through changes in gene expression