Air Pollution and Acute Respiratory Response in a Panel of Asthmatic Children along the U.S.–Mexico Border

Background: Concerns regarding the health impact of urban air pollution on asthmatic children are pronounced along the U.S.–Mexico border because of rapid population growth near busy border highways and roads. Objectives: We conducted the first binational study of the impacts of air pollution on asthmatic children in Ciudad Juarez, Mexico, and El Paso, Texas, USA, and compared different exposure metrics to assess acute respiratory response. Methods: We recruited 58 asthmatic children from two schools in Ciudad Juarez and two schools in El Paso. A marker of airway inflammation [exhaled nitric oxide (eNO)], respiratory symptom surveys, and pollutant measurements (indoor and outdoor 48-hr size-fractionated particulate matter, 48-hr black carbon, and 96-hr nitrogen dioxide) were collected at each school for 16 weeks. We examined associations between the pollutants and respiratory response using generalized linear mixed models. Results: We observed small but consistent associations between eNO and numerous pollutant metrics, with estimated increases in eNO ranging from 1% to 3% per interquartile range increase in pollutant concentrations. Effect estimates from models using school-based concentrations were generally stronger than corresponding estimates based on concentrations from ambient air monitors. Both traffic-related and non–traffic-related particles were typically more robust predictors of eNO than was nitrogen dioxide, for which associations were highly sensitive to model specification. Associations differed significantly across the four school-based cohorts, consistent with heterogeneity in pollutant concentrations and cohort characteristics. Models examining respiratory symptoms were consistent with the null. Conclusions: The results indicate adverse effects of air pollution on the subclinical respiratory health of asthmatic children in this region and provide preliminary support for the use of air pollution monitors close to schools to track exposure and potential health risk in this population

Air Pollution and Acute Respiratory Response in a Panel of Asthmatic Children along the U.S.–Mexico Border

Background: Concerns regarding the health impact of urban air pollution on asthmatic children are pronounced along the U.S.–Mexico border because of rapid population growth near busy border highways and roads

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The association of vitamin D status with allergy and asthma in children: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005-2006

About 23 million people, including almost 10 million children, have asthma in the United States. Asthma prevalence is higher among families with lower incomes living at the US/ Mexico Border and represents the most common serious chronic diseases of childhood. It is the third-ranking cause of hospitalization among children under 15, (De Frances, 2007) as well as the cause of seven million physician visits and nearly 200,000 hospitalizations every year. An average of one out of every ten school-aged children has asthma and, 13 million school days are missed each year due to asthma symptoms (Akinbami, 2006). According to the National Heart, Lung, and Blood Institute (NHBLI, 2009) annual expenditures for health and lost productivity due to asthma are estimated at over $20 billion. Recently, research has shown that low serum levels of Vitamin D might be associated with poor asthma control (Bhrem, 2010), but the exact mechanism is still unknown. Studies about the potential effect of vitamin D are largely based on observational studies that lack measurements of serum levels. This dissertation used National Health and Nutrition Examination and Survey (NHANES) data from 2005-2006 to examine the relationship between vitamin D, asthma and allergy among 1884 U.S. children age 6-15. Data from 2005-2006, included serum levels of vitamin D [25(OH) D], questionnaires of asthma and allergy symptoms, sociodemographic characteristics, and assays for total and allergen-specific IgE. A mediation analysis was performed to explore the mediation effect of IgE between the relationship of vitamin D and asthma symptoms. The prevalence of asthma observed in this cross-sectional study was 16.3% .The majority of study children (86%) had serum vitamin D levels below an accepted optimal threshold \u3c or =30 ng/mL, with mean ± SDs of 22.13 ± 7.8 ng/mL. The risk of asthma diagnosis was higher among children with deficient serum levels of 25(OH) D compared with children with sufficient vitamin D status (OR, 1.53; 95% CI, 1.00-2.33). Similarly, allergy diagnosis was associated with vitamin D deficiency (OR,o 1.58; 95% CI (1.10-2.27) in a multivariate model adjusted for age, gender, parental education and BMI. The mediation analysis showed that vitamin D was negatively related to asthma severity and that Immunoglobulin E [IE= -.013, 95% CI [-.023,-005] mediated this relationship. Gender moderated this relationship such that these associations were stronger for boys than for girls. Overall, the results suggest that addressing reduction of vitamin D deficiencies could be a potential public health strategy to decrease asthma and allergy severity in childre

Physical Activity in Older Mexican Americans Living in Two Cities on the U.S.-Mexico Border

Background: There is limited information on physical activity in marginalized older populations like that on the U.S.-Mexico border. This study aims to understand physical activity engagement among older Hispanics residing in two U.S.-Mexico Border counties. Methods: The International Physical Activity Questionnaire (IPAQ) was used to measure physical activity in El Paso and Cameron County, Texas. Physical activity levels were reported for vigorous, moderate, and walking met/mins. Adjusted and unadjusted modeling was conducted to determine county differences and sociodemographic covariates. Results: There were 784 participants and 92.9% were less than 65 years of age. El Paso participants reported a significantly greater natural log met/mins of vigorous (β = 1.34, p = 0.000) and walking (β = 0.331, p = 0.006). Significant sociodemographic covariates in El Paso for vigorous met/mins were gender (females β = −1.20, p = 0.003), having a regular doctor (β = −0.779, p = 0.029), and acculturation (β = 0.513, p = 0.019). Significant associations in Cameron County were having a regular doctor (β = −1.03, p = 0.000) and fair/poor health status (β = −0.475, p = 0.001). Conclusion: Level of physical activity may differ in older Hispanics by urban context on the U.S.-Mexico border. Future physical activity programs to promote physical activity should take context into consideration

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit