Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Oxidative stress (OS) is implicated in several chronic diseases. Extra-cellular superoxide dismutase (ec-SOD) catalyses the dismutation of superoxide anions with a protective role in endothelial cells. In chronic kidney disease (CKD), OS and thyroid dysfunction (low fT3 syndrome) are frequently present, but their relationship has not yet been investigated. This cohort study evaluated ec-SOD activity in CKD patients during haemodialysis, divided into "acute haemodialytic patients" (AH, 1-3 months of treatment) and "chronic haemodialytic patients" (CH, treated for a longer period). We also evaluated plasmatic total antioxidant capacity (TAC) and its relationships with thyroid hormones. Two basal samples ("basal 1", obtained 3 days after the last dialysis; and "basal 2", obtained 2 days after the last dialysis) were collected. On the same day of basal 2, a sample was collected 5 and 10 min after the standard heparin dose and at the end of the procedure. The ec-SOD values were significantly higher in CH vs. AH in all determinations. Moreover, the same patients had lower TAC values. When the CH patients were divided into two subgroups according to fT3 levels (normal or low), we found significantly lower ec-SOD values in the group with low fT3 in the basal, 5, and 10 min samples. A significant correlation was also observed between fT3 and ec-SOD in the basal 1 samples. These data, confirming OS and low fT3 syndrome in patients with CKD, suggest that low fT3 concentrations can influence ec-SOD activity and could therefore potentially contribute to endothelial oxidative damage in these patients

B-physics computations from Nf=2 tmQCD

We present an accurate lattice QCD computation of the b-quark mass, the B and Bs decay constants, the B-mixing bag-parameters for the full four-fermion operator basis, as well as estimates for \xi and f_{Bq}\sqrt{B_q} extrapolated to the continuum limit and the physical pion mass. We have used Nf = 2 dynamical quark gauge configurations at four values of the lattice spacing generated by ETMC. Extrapolation in the heavy quark mass from the charm to the bottom quark region has been carried out using ratios of physical quantities computed at nearby quark masses, having an exactly known infinite mass limit.Comment: 7 pages, 4 figures, presented at the 31st International Symposium on Lattice Field Theory (Lattice 2013), 29 July - 3 August 2013, Mainz, German

Minimal gauge-Higgs unification with a flavour symmetry

We show that a flavour symmetry a la Froggatt-Nielsen can be naturally incorporated in models with gauge-Higgs unification, by exploiting the heavy fermions that are anyhow needed to realize realistic Yukawa couplings. The case of the minimal five-dimensional model, in which the SU(2)_L x U(1)_Y electroweak group is enlarged to an SU(3)_W group, and then broken to U(1)_em by the combination of an orbifold projection and a Scherk-Schwarz twist, is studied in detail. We show that the minimal way of incorporating a U(1)_F flavour symmetry is to enlarge it to an SU(2)_F group, which is then completely broken by the same orbifold projection and Scherk-Schwarz twist. The general features of this construction, where ordinary fermions live on the branes defined by the orbifold fixed-points and messenger fermions live in the bulk, are compared to those of ordinary four-dimensional flavour models, and some explicit examples are constructed.Comment: LaTex, 37 pages, 2 figures; some clarifying comments and a few references adde

Non-local symmetry breaking in Kaluza-Klein theories

Scherk-Schwarz gauge symmetry breaking of a D-dimensional field theory model compactified on a circle is analyzed. It is explicitly shown that forbidden couplings in the unbroken theory appear in the one-loop effective action only in a non-local way, implying that they are finite at all orders in perturbation theory. This result can be understood as a consequence of the local gauge symmetry, but it holds true also in the global limit.Comment: v2: Wilson loop contributions and generalization to SU(N) included; references added. v3: version to appear in Phys. Rev. Let

Gauge-Higgs Unification in Orbifold Models

Six-dimensional orbifold models where the Higgs field is identified with some internal component of a gauge field are considered. We classify all possible T^2/Z_N orbifold constructions based on a SU(3) electroweak gauge symmetry. Depending on the orbifold twist, models with two, one or zero Higgs doublets can be obtained. Models with one Higgs doublet are particularly interesting because they lead to a prediction for the Higgs mass, which is twice the W boson mass at leading order: m_H=2 m_W. The electroweak scale is quadratically sensitive to the cut-off, but only through very specific localized operators. We study in detail the structure of these operators at one loop, and identify a class of models where they do not destabilize the electroweak scale at the leading order. This provides a very promising framework to construct realistic and predictive models of electroweak symmetry breaking.Comment: 27 pages, uses axodraw.sty; v2: version to appear in JHE

Individualized Prediction of Drug Resistance in People with Post-Stroke Epilepsy: A Retrospective Study

Background: The study aimed to develop a model and build a nomogram to predict the probability of drug resistance in people with post-stroke epilepsy (PSE). Methods: Subjects with epilepsy secondary to ischemic stroke or spontaneous intracerebral hemorrhage were included. The study outcome was the occurrence of drug-resistant epilepsy defined according to International League Against Epilepsy criteria. Results: One hundred and sixty-four subjects with PSE were included and 32 (19.5%) were found to be drug-resistant. Five variables were identified as independent predictors of drug resistance and were included in the nomogram: age at stroke onset (odds ratio (OR): 0.941, 95% confidence interval (CI) 0.907–0.977), intracerebral hemorrhage (OR: 6.292, 95% CI 1.957–20.233), severe stroke (OR: 4.727, 95% CI 1.573–14.203), latency of PSE (>12 months, reference; 7–12 months, OR: 4.509, 95% CI 1.335–15.228; 0–6 months, OR: 99.099, 95% CI 14.873–660.272), and status epilepticus at epilepsy onset (OR: 14.127, 95% CI 2.540–78.564). The area under the receiver operating characteristic curve of the nomogram was 0.893 (95% CI: 0.832–0.956). Conclusions: Great variability exists in the risk of drug resistance in people with PSE. A nomogram based on a set of readily available clinical variables may represent a practical tool for an individualized prediction of drug-resistant PSE