Scalar radiation from Chameleon-shielded regions

I study the profile of the Chameleon field around a radially pulsating mass. Focusing on the case in which the background (static) Chameleon profile exhibits a thin-shell, I add small perturbations to the source in the form of time-dependent radial pulsations. It is found that the Chameleon field inherits a time-dependence, there is a resultant scalar radiation from the region of the source and the metric outside the spherically symmetric mass is not static. This has several interesting and potentially testable consequences.Comment: 4 pages, 4 figures, slightly edited version matching the journal versio

Microtaphofacies analysis of lower Oligocene turbid-water coral assemblages

The presence, distribution, and preservation of coral-rich facies in the lower Oligocene Gornji Grad Beds of Slovenia are analyzed using a microtaphofacies approach. This method allows taphonomic signatures to be recognized in thin section along with the presence of coral specimens and growth forms within and between stratigraphic logs. Coral-dominated limestones within the Gornji Grad Beds are represented by rudstones in a packstone-wackestone matrix. The conditions are generally reconstructedas turbid water due to the prevalence of muddy carbonate matrix, which also leads to excellently preserved morphological features in thin section. These beds represent a reference area for the study of Paleogene corals, especially during the Oligocene, a key phase of reef development during the Cenozoic. This study also contributes to the characterization of fossil reefs in turbid-water environments. The evaluated coral fauna is dominated by delicate-branching Stylophora and Acropora, although thickly branching (Actinacis, Goniopora), phaceloid (Caulastrea), and massive forms (Alveopora, Astreopora, Antiguastrea) also occur. Assessed taphonomic signatures include fragmentation, abrasion, bioerosion, and encrustation. Three types of bioerosion traces are distinguished (Entobia, Gastrochoenolites, Trypanites). Encrustation includes both thincrusts and complex multi-taxon sequences dominated by coralline algae. Five microtaphofacies are distinguished based on variation of taphonomic signatures, taxonomic composition, and growth forms. Differences in microtaphofacies are interpreted with respect to turbidity, sediment accumulation, and water turbulence; both parautochthonous and allochthonous deposits are reconstructed. A depositional model based on the distribution of microtaphofacies in the studied sections shows a succession of coral communities with different colonization strategies reflecting generally high stress levels

Chiral Anomalies via Classical and Quantum Functional Methods

In the quantum path integral formulation of a field theory model an anomaly arises when the functional measure is not invariant under a symmetry transformation of the Lagrangian. In this paper, generalizing previous work done on the point particle, we show that even at the classical level we can give a path integral formulation for any field theory model. Since classical mechanics cannot be affected by anomalies, the measure of the classical path integral of a field theory must be invariant under the symmetry. The classical path integral measure contains the fields of the quantum one plus some extra auxiliary ones. So, at the classical level, there must be a sort of "cancellation" of the quantum anomaly between the original fields and the auxiliary ones. In this paper we prove in detail how this occurs for the chiral anomaly.Comment: 26 pages, Latex, misprint fixed, a dedication include

Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities

Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes – NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay. Subsequently, we performed an enzyme-based assay to clarify the action of these compounds against DENV RdRp or NS3 protease activity. Moreover, these compounds exhibited anti-DENV activity in vivo in the ICR-suckling DENV-infected mouse model. Combination drug treatment exhibited a synergistic inhibition of DENV replication. These results describe novel prototypical small anti-DENV molecules for further development through compound modification and provide potential antivirals for treating DENV infection and DENV-related diseases

The Chromospheric Activity and Ages of M Dwarf Stars in Wide Binary Systems

We investigate the relationship between age and chromospheric activity for 139 M dwarf stars in wide binary systems with white dwarf companions. The age of each system is determined from the cooling age of its white dwarf component. The current limit for activity-age relations found for M dwarfs in open clusters is 4 Gyr. Our unique approach to finding ages for M stars allows for the exploration of this relationship at ages older than 4 Gyr. The general trend of stars remaining active for a longer time at later spectral type is confirmed. However, our larger sample and greater age range reveals additional complexity in assigning age based on activity alone. We find that M dwarfs in wide binaries older than 4 Gyr depart from the log-linear relation for clusters and are found to have activity at magnitudes, colors and masses which are brighter, bluer and more massive than predicted by the cluster relation. In addition to our activity-age results, we present the measured radial velocities and complete space motions for 161 white dwarf stars in wide binaries.Comment: 22 pages including 9 figures and 5 tables. Accepted for publication in The Astronomical Journa

SDSS J210014.12+004446.0: A New Dwarf Nova with Quiescent Superhumps?

We report follow-up observations of the Sloan Digital Sky Survey Cataclysmic Variable SDSS J210014.12+004446.0 (hereafter SDSS J2100). We obtained photometry and spectroscopy in both outburst and quiescent states, providing the first quiescent spectrum of this source. In both states, non-sinusoidal photometric modulations are apparent, suggestive of superhumps, placing SDSS J2100 in the SU UMa subclass of dwarf novae. However, the periods during outburst and quiescence differ significantly, being 2.099 plus or minus 0.002 hr and 1.96 plus or minus 0.02 hr respectively. Our phase-resolved spectroscopy during outburst yielded an estimate of about 2 hr for the orbital period, consistent with the photometry. The presence of the shorter period modulation at quiescence is unusual, but not unique. Another atypical feature is the relative weakness of the Balmer emission lines in quiescence. Overall, we find a close similarity between SDSS J2100 and the well-studied superhump cataclysmic Variable V503 Cygni. By analogy, we suggest that the quiescent modulation is due to a tilted accretion disk -- producing negative superhumps -- and the modulation in outburst is due to positive superhumps from the precession of an elliptical disk.Comment: 6 pages, 5 eps figures, accepted by PASP Dec. 16th, 200

The era of nano-bionic: 2D materials for wearable and implantable body sensors

Nano-bionics have the potential of revolutionizing modern medicine. Among nano-bionic devices, body sensors allow to monitor in real-time the health of patients, to achieve personalized medicine, and even to restore or enhance human functions. The advent of two-dimensional (2D) materials is facilitating the manufacturing of miniaturized and ultrathin bioelectronics, that can be easily integrated in the human body. Their unique electronic properties allow to efficiently transduce physical and chemical stimuli into electric current. Their flexibility and nanometric thickness facilitate the adaption and adhesion to human body. The low opacity permits to obtain transparent devices. The good cellular adhesion and reduced cytotoxicity are advantageous for the integration of the devices in vivo. Herein we review the latest and more significant examples of 2D material-based sensors for health monitoring, describing their architectures, sensing mechanisms, advantages and, as well, the challenges and drawbacks that hampers their translation into commercial clinical devices

Use of an anatomical mid-sagittal plane for 3-dimensional cephalometry: a preliminary study

Purpose: Cone-beam computed tomography (CBCT) is widely used for 3-dimensional assessments of cranio-maxillo-facial relationships, especially in patients undergoing orthognathic surgery. We have introduced, for reference in CBCT cephalometry, an anatomical mid-sagittal plane (MSP) identified by the nasion, the midpoint between the posterior clinoid processes of the sella turcica, and the basion. The MSP is an updated version of the median plane previously used at our institution for 2D posterior-anterior cephalometry. This study was conducted to test the accuracy of the CBCT measures compared to those obtained using standard posterior-anterior cephalometry.Materials and Methods: Two operators measured the inter-zygomatic distance on 15 CBCT scans using the MSP as a reference plane, and the CBCT measurements were compared with measurements made on patients' posterior-anterior cephalograms. The statistical analysis evaluated the absolute and percentage differences between the 3D and 2D measurements.Results: As demonstrated by the absolute mean difference (roughly 1 mm) and the percentage difference (less than 3%), the MSP showed good accuracy on CBCT compared to the 2D plane, especially for measurements of the left side. However, the CBCT measurements showed a high standard deviation, indicating major variability and low precision.Conclusion: The anatomical MSP can be used as a reliable reference plane for transverse measurements in 3D cephalometry in cases of symmetrical or asymmetrical malocclusion. In patients who suffer from distortions of the skull base, the identification of landmarks might be difficult and the MSP could be unreliable. Becoming familiar with the relevant software could reduce errors and improve reliability