Towards a Realistic Model for Failure Propagation in Interdependent Networks

Modern networks are becoming increasingly interdependent. As a prominent example, the smart grid is an electrical grid controlled through a communications network, which in turn is powered by the electrical grid. Such interdependencies create new vulnerabilities and make these networks more susceptible to failures. In particular, failures can easily spread across these networks due to their interdependencies, possibly causing cascade effects with a devastating impact on their functionalities. In this paper we focus on the interdependence between the power grid and the communications network, and propose a novel realistic model, HINT (Heterogeneous Interdependent NeTworks), to study the evolution of cascading failures. Our model takes into account the heterogeneity of such networks as well as their complex interdependencies. We compare HINT with previously proposed models both on synthetic and real network topologies. Experimental results show that existing models oversimplify the failure evolution and network functionality requirements, resulting in severe underestimations of the cascading failures.Comment: 7 pages, 6 figures, to be published in conference proceedings of IEEE International Conference on Computing, Networking and Communications (ICNC 2016), Kauai, US

Chiral Anomalies via Classical and Quantum Functional Methods

In the quantum path integral formulation of a field theory model an anomaly arises when the functional measure is not invariant under a symmetry transformation of the Lagrangian. In this paper, generalizing previous work done on the point particle, we show that even at the classical level we can give a path integral formulation for any field theory model. Since classical mechanics cannot be affected by anomalies, the measure of the classical path integral of a field theory must be invariant under the symmetry. The classical path integral measure contains the fields of the quantum one plus some extra auxiliary ones. So, at the classical level, there must be a sort of "cancellation" of the quantum anomaly between the original fields and the auxiliary ones. In this paper we prove in detail how this occurs for the chiral anomaly.Comment: 26 pages, Latex, misprint fixed, a dedication include

Experimental multiphase estimation on a chip

Multiparameter estimation is a general problem that aims at measuring unknown physical quantities, obtaining high precision in the process. In this context, the adoption of quantum resources promises a substantial boost in the achievable performances with respect to the classical case. However, several open problems remain to be addressed in the multiparameter scenario. A crucial requirement is the identification of suitable platforms to develop and experimentally test novel efficient methodologies that can be employed in this general framework. We report the experimental implementation of a reconfigurable integrated multimode interferometer designed for the simultaneous estimation of two optical phases. We verify the high-fidelity operation of the implemented device, and demonstrate quantum-enhanced performances in two-phase estimation with respect to the best classical case, post-selected to the number of detected coincidences. This device can be employed to test general adaptive multiphase protocols due to its high reconfigurability level, and represents a powerful platform to investigate the multiparameter estimation scenario.Comment: 10+7 pages, 7+4 figure

The coherent dynamics of photoexcited green fluorescent proteins

The coherent dynamics of vibronic wave packets in the green fluorescent protein is reported. At room temperature the non-stationary dynamics following impulsive photoexcitation displays an oscillating optical transmissivity pattern with components at 67 fs (497 cm-1) and 59 fs (593 cm-1). Our results are complemented by ab initio calculations of the vibrational spectrum of the chromophore. This analysis shows the interplay between the dynamics of the aminoacidic structure and the electronic excitation in the primary optical events of green fluorescent proteins.Comment: accepted for publication in Physical Review Letter

The Marvin Project: an Omni-Directional Robot for Home Assistance

In the last decades, many researchers are investigating how robotic solutions may be adopted to address the increasing need for home and personal assistance aggravated by current global challenges, e.g. population ageing and pandemic emergency. In this direction, the researchers at Politecnico di Torino, together with the colleagues from Edison S.p.A., developed the Marvin project which aims at designing a useful mobile robot for the domestic environment. In this work, the main features of the Marvin prototype and a first qualitative experimental validation are presented

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps

This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic transformation and regeneration in Italy during the 1980s. Following his scientific interests as guiding principles, this review summarizes the recent advances obtained in plant biotechnology and fundamental research aiming to: (i) Exploit in vitro plant cell and tissue cultures to induce genetic variability and to produce useful metabolites; (ii) gain new insights into the biochemical function of Agrobacterium rhizogenes rol genes and their application to metabolite production, fruit tree transformation, and reverse genetics; (iii) improve genetic transformation in legume species, most of them recalcitrant to regeneration; (iv) untangle the potential of KNOTTED1-like homeobox (KNOX) transcription factors in plant morphogenesis as key regulators of hormonal homeostasis; and (v) elucidate the molecular mechanisms of the transition from juvenility to the adult phase in Prunus tree species

Escherichia coli specific secretory IgA and cytokines in human milk from mothers of different ethnic groups resident in northern Italy.

Breast milk supplies many bioactive components. Neonates protection from pathogenic bacteria is mainly attributable to secretory IgA antibodies present in human milk in an amount depending on previous antigenic exposure. To bring new details into the field of immunological memory in secretory immunity, we evaluated the production of s-IgA specific for E. coli (E. coli s-IgA), and of proinflammatory (IL-6 and IL-8) or anti-inflammatory (IL-10) cytokines in the milk of mothers of different ethnic groups exposed in the past to poor conditions, but nowadays living in Italy in adequate conditions. Mothers from Italy, Africa, Asia and Eastern European Countries were included in the study. Anti- E. coli s-IgA, IL-6, IL-8 and IL-10 were determined by ELISA. Breast milk of all the foreign mothers presented higher levels of E. coli s-IgA than Italians, and for Asian and African mothers were significative (p=0.031 and p=0.015, respectively). Milk from women of Eastern European Countries revealed the highest IL-8 levels (p=0.026), while milk from Asian women presented the greatest concentration of IL-6 (p=0.04); however, the Africans reported the lowest concentrations of IL-10 (p=0.045). Since all the mothers had been living in Italy for some time, we believe that the presence of high levels of E. coli s-IgA, supported by high levels of pro-inflammatory cytokine, is part of a persisting immunological secretory memory

Persistent SARS-CoV-2 infection in patients seemingly recovered from COVID-19

SARS-CoV-2 infection is clinically heterogeneous, ranging from asymptomatic to deadly. A few patients with COVID-19 appear to recover from acute viral infection but nevertheless progress in their disease and eventually die, despite persistent negativity at molecular tests for SARS-CoV-2 RNA. Here, we performed post-mortem analyses in 27 consecutive patients who had apparently recovered from COVID-19 but had progressively worsened in their clinical conditions despite repeated viral negativity in nasopharyngeal swabs or bronchioalveolar lavage for 11-300 consecutive days (average: 105.5 days). Three of these patients remained PCR-negative for over 9 months. Post-mortem analysis revealed evidence of diffuse or focal interstitial pneumonia in 23/27 (81%) patients, accompanied by extensive fibrotic substitution in 13 cases (47%). Despite apparent virological remission, lung pathology was similar to that observed in acute COVID-19 individuals, including micro- and macro-vascular thrombosis (67% of cases), vasculitis (24%), squamous metaplasia of the respiratory epithelium (30%), frequent cytological abnormalities and syncytia (67%), and the presence of dysmorphic features in the bronchial cartilage (44%). Consistent with molecular test negativity, SARS-CoV-2 antigens were not detected in the respiratory epithelium. In contrast, antibodies against both spike and nucleocapsid revealed the frequent (70%) infection of bronchial cartilage chondrocytes and para-bronchial gland epithelial cells. In a few patients (19%), we also detected positivity in vascular pericytes and endothelial cells. Quantitative RT-PCR amplification in tissue lysates confirmed the presence of viral RNA. Together, these findings indicate that SARS-CoV-2 infection can persist significantly longer than suggested by standard PCR-negative tests, with specific infection of specific cell types in the lung. Whether these persistently infected cells also play a pathogenic role in long COVID remains to be addressed. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland

Experimental Quenching of Harmonic Stimuli: Universality of Linear Response Theory

This article discusses experimental quenching of harmonic stimuli