2,095 research outputs found
Compactification on negatively curved manifolds
We show that string/M theory compactifications to maximally symmetric
space-times using manifolds whose scalar curvature is everywhere negative, must
have significant warping, large stringy corrections, or both.Comment: 18 pages, JHEP3.cl
The Effective Field Theory of Multifield Inflation
We generalize the Effective Field Theory of Inflation to include additional
light scalar degrees of freedom that are in their vacuum at the time the modes
of interest are crossing the horizon. In order to make the scalars light in a
natural way we consider the case where they are the Goldstone bosons of a
global symmetry group or are partially protected by an approximate
supersymmetry. We write the most general Lagrangian that couples the scalar
mode associated to the breaking of time translation during inflation to the
additional light scalar fields. This Lagrangian is constrained by
diffeomorphism invariance and the additional symmetries that keep the new
scalars light. This Lagrangian describes the fluctuations around the time of
horizon crossing and it is supplemented with a general parameterization
describing how the additional fluctuating fields can affect cosmological
perturbations. We find that multifield inflation can reproduce the
non-Gaussianities that can be generated in single field inflation but can also
give rise to new kinds of non-Gaussianities. We find several new three-point
function shapes. We show that in multifield inflation it is possible to
naturally suppress the three-point function making the four-point function the
leading source of detectable non-Gaussianities. We find that under certain
circumstances, i.e. if specific shapes of non-Gaussianities are detected in the
data, one could distinguish between single and multifield inflation and
sometimes even among the various mechanisms that kept the additional fields
light.Comment: 62 pages, 1 figure; v2: JHEP published version, minor corrections,
comments and references adde
Anomalous Dimensions and Non-Gaussianity
We analyze the signatures of inflationary models that are coupled to strongly
interacting field theories, a basic class of multifield models also motivated
by their role in providing dynamically small scales. Near the squeezed limit of
the bispectrum, we find a simple scaling behavior determined by operator
dimensions, which are constrained by the appropriate unitarity bounds.
Specifically, we analyze two simple and calculable classes of examples:
conformal field theories (CFTs), and large-N CFTs deformed by relevant
time-dependent double-trace operators. Together these two classes of examples
exhibit a wide range of scalings and shapes of the bispectrum, including nearly
equilateral, orthogonal and local non-Gaussianity in different regimes. Along
the way, we compare and contrast the shape and amplitude with previous results
on weakly coupled fields coupled to inflation. This signature provides a
precision test for strongly coupled sectors coupled to inflation via irrelevant
operators suppressed by a high mass scale up to 1000 times the inflationary
Hubble scale.Comment: 40 pages, 10 figure
Risk stratification by pre-operative cardiopulmonary exercise testing improves outcomes following elective abdominal aortic aneurysm surgery : a cohort study
Background:
In 2009, the NHS evidence adoption center and National Institute for Health and Care Excellence (NICE) published a review of the use of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs). They recommended the development of a risk-assessment tool to help identify AAA patients with greater or lesser risk of operative mortality and to contribute to mortality prediction.
A low anaerobic threshold (AT), which is a reliable, objective measure of pre-operative cardiorespiratory fitness, as determined by pre-operative cardiopulmonary exercise testing (CPET) is associated with poor surgical outcomes for major abdominal surgery. We aimed to assess the impact of a CPET-based risk-stratification strategy upon perioperative mortality, length of stay and non-operative costs for elective (open and endovascular) infra-renal AAA patients.
Methods:
A retrospective cohort study was undertaken. Pre-operative CPET-based selection for elective surgical intervention was introduced in 2007. An anonymized cohort of 230 consecutive infra-renal AAA patients (2007 to 2011) was studied. A historical control group of 128 consecutive infra-renal AAA patients (2003 to 2007) was identified for comparison.
Comparative analysis of demographic and outcome data for CPET-pass (AT ≥ 11 ml/kg/min), CPET-fail (AT < 11 ml/kg/min) and CPET-submaximal (no AT generated) subgroups with control subjects was performed. Primary outcomes included 30-day mortality, survival and length of stay (LOS); secondary outcomes were non-operative inpatient costs.
Results:
Of 230 subjects, 188 underwent CPET: CPET-pass n = 131, CPET-fail n = 35 and CPET-submaximal n = 22. When compared to the controls, CPET-pass patients exhibited reduced median total LOS (10 vs 13 days for open surgery, n = 74, P < 0.01 and 4 vs 6 days for EVAR, n = 29, P < 0.05), intensive therapy unit requirement (3 vs 4 days for open repair only, P < 0.001), non-operative costs (£5,387 vs £9,634 for open repair, P < 0.001) and perioperative mortality (2.7% vs 12.6% (odds ratio: 0.19) for open repair only, P < 0.05). CPET-stratified (open/endovascular) patients exhibited a mid-term survival benefit (P < 0.05).
Conclusion:
In this retrospective cohort study, a pre-operative AT > 11 ml/kg/min was associated with reduced perioperative mortality (open cases only), LOS, survival and inpatient costs (open and endovascular repair) for elective infra-renal AAA surgery
On graviton non-Gaussianities during inflation
We consider the most general three point function for gravitational waves
produced during a period of exactly de Sitter expansion. The de Sitter
isometries constrain the possible shapes to only three: two preserving parity
and one violating parity. These isometries imply that these correlation
functions should be conformal invariant. One of the shapes is produced by the
ordinary gravity action. The other shape is produced by a higher derivative
correction and could be as large as the gravity contribution. The parity
violating shape does not contribute to the bispectrum [1106.3228, 1108.0175],
even though it is present in the wavefunction. We also introduce a spinor
helicity formalism to describe de Sitter gravitational waves with circular
polarization. These results also apply to correlation functions in Anti-de
Sitter space. They also describe the general form of stress tensor correlation
functions, in momentum space, in a three dimensional conformal field theory.
Here all three shapes can arise, including the parity violating one.Comment: 51 pages, v2: Corrected statement about parity violation in the
gravitational wave bispectrum. Some other changes and references adde
Universal de Sitter solutions at tree-level
Type IIA string theory compactified on SU(3)-structure manifolds with
orientifolds allows for classical de Sitter solutions in four dimensions. In
this paper we investigate these solutions from a ten-dimensional point of view.
In particular, we demonstrate that there exists an attractive class of de
Sitter solutions, whose geometry, fluxes and source terms can be entirely
written in terms of the universal forms that are defined on all SU(3)-structure
manifolds. These are the forms J and Omega, defining the SU(3)-structure
itself, and the torsion classes. The existence of such universal de Sitter
solutions is governed by easy-to-verify conditions on the SU(3)-structure,
rendering the problem of finding dS solutions purely geometrical. We point out
that the known (unstable) solution coming from the compactification on SU(2)x
SU(2) is of this kind.Comment: 20 pages, 3 figures, v2: added reference
Ultrasound findings and histological features of ductal carcinoma in situ detected by ultrasound examination alone
Probe Branes, Time-dependent Couplings and Thermalization in AdS/CFT
We present holographic descriptions of thermalization in conformal field
theories using probe D-branes in AdS X S space-times. We find that the induced
metrics on Dp-brane worldvolumes which are rotating in an internal sphere
direction have horizons with characteristic Hawking temperatures even if there
is no black hole in the bulk AdS. The AdS/CFT correspondence applied to such
systems indeed reveals thermal properties such as Brownian motions and AC
conductivities in the dual conformal field theories. We also use this framework
to holographically analyze time-dependent systems undergoing a quantum quench,
where parameters in quantum field theories, such as a mass or a coupling
constant, are suddenly changed. We confirm that this leads to thermal behavior
by demonstrating the formation of apparent horizons in the induced metric after
a certain time.Comment: LaTeX, 47 pages, 14 figures; Typos corrected and references added
(v2); minor corrections, references added(v3
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