PND43 Cost-Effectiveness of Subcutaneous Verse Intramuscular Interferon Beta-1A In Portugal Based on the Findings of Cochrane Collaboration Review of First-Line Treatments for Relapsing-Remitting Multiple Sclerosis

This paper considers the potential impact that the nascent technology of quantum computing may have on society. It focuses on three areas: cryptography, optimization, and simulation of quantum systems. We will also discuss some ethical aspects of these developments, and ways to mitigate the risks

Revolución y retazos de gramática parda del maestro Ciruela

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-201

3D-QSARpy: Combining variable selection strategies and machine learning techniques to build QSAR models

Quantitative Structure-Activity Relationship (QSAR) is a computer-aided technology in the field of medicinal chemistry that seeks to clarify the relationships between molecular structures and their biological activities. Such technologies allow for the acceleration of the development of new compounds by reducing the costs of drug design. This work presents 3D-QSARpy, a flexible, user-friendly and robust tool, freely available without registration, to support the generation of QSAR 3D models in an automated way. The user only needs to provide aligned molecular structures and the respective dependent variable. The current version was developed using Python with packages such as scikit-learn and includes various techniques of machine learning for regression. The diverse techniques employed by the tool is a differential compared to known methodologies, such as CoMFA and CoMSIA, because it expands the search space of possible solutions, and in this way increases the chances of obtaining relevant models. Additionally, approaches for select variables (dimension reduction) were implemented in the tool. To evaluate its potentials, experiments were carried out to compare results obtained from the proposed 3D-QSARpy tool with the results from already published works. The results demonstrated that 3D-QSARpy is extremely useful in the field due to its expressive results

Recuerdos de Buenos Aires : pasatiempo seudo-literario

Copia digital : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Estraña [sic] evolución del bacilo Coma

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-201

Inverosimilitudes bacteriológicas ó Revelaciones microbianas

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2012-201

Ecos de un rincón de España : impresiones de un paseo

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 201

Psychometric evaluation and validation of the Postpartum Specific Anxiety Scale for the Spanish-speaking population: PSAS-ES

Objective: The transition to motherhood is a period of risk for the development of mood disorders. Postpartum anxiety has not been as thoroughly studied as other emotional disorders despite its impact on mothers and their babies. The absence of standardized programmes for early detection and specific tools for its diagnosis means postpartum anxiety is often underestimated or overshadowed. This study aimed to translate and validate the Postpartum Specific Anxiety Scale [PSAS] for the Spanish population and to analyse its reliability as an exploratory tool for specific anxiety in mothers. Method: Four stages were followed in this research: translation and back-translation to obtain the Spanish version [PSAS-ES]; preliminary pilot study to explore the comprehensibility and ease of responding the items (n = 53); convergent validity analyses (n = 644); and test-retest reliability (n = 234). Results: The PSAS-ES has shown to have good acceptability, convergent validity and high internal consistency with a Cronbach's α coefficient of 0.93 for the overall scale of PSAS. The four factors had good reliability. The results of test-retest was 0.86, indicating excellent stability over time in the first 16 weeks. Conclusion: The psychometric results show that the PSAS-ES is a valid tool to explore and detect anxiety in Spanish mothers between 0 and 16 weeks postpartum

The (un)controlled body: A grounded theory analysis to conceptualise stigma for women with gestational diabetes mellitus

Health-related stigma is associated with adverse outcomes including depression, stress, and reduced engagement in health behaviours which are particularly harmful in pregnancy and postpartum. Women with gestational diabetes mellitus (GDM) report negative psychosocial experiences and may be at risk of stigma related to the condition. We aimed to understand women’s experiences of GDM-specific stigma. Individual interviews were conducted with n=53 women living in the UK with current or past (within four years) GDM. Grounded theory methodology was used to analyse the data. Four themes were identified: 1. Preconceptions and misconceptions; 2. Locating, regaining, and negotiating agency; 3. Tension about and resisting the dominant discourse of stigma; and 4. Reclaiming control over the body. GDM-specific stigma was diverse and far reaching and may have broader implications for perinatal mental health and postnatal wellbeing. It is pertinent to investigate possible prospective associations between GDMspecific stigma and biomedical and mental health outcomes