Insulin Resistance and Atherosclerosis

O tipo de vida nas sociedades ocidentais favorece, nos indivíduos geneticamente predispostos, o desenvolvimento do estado de insulino-resistência. Neste estado, são necessárias concentrações de insulina mais elevadas para que se obtenha uma normal resposta metabólica nos tecidos-alvo, ocasionando o desenvolvimento de hiperinsulinismo. Em consequência da multiplicidade de acções da insulina, a insulino-resistência está associada a disfunção de vários tecidos,orgãos e sistemas (Síndrome X), tendo por consequência, entre outras, um aumento do risco de patologia vascular aterosclerótica. Neste artigo, são revistas as alterações a nível do controlo da pressão arterial, endotélio vascular, metabolismo lipídico e sistema fibrinolítico, consequentes ao estado de insulino resistência e a forma como, junto com o hiperinsulinismo, aceleram o processo da aterogénese. São, igualmente, abordadas algumas das armas terapêuticas capazes de combater aquele estado e, assim, reduzir a morbilidade e mortalidade associadas à aterosclerose

Production of thermoplastic matrix towpregs for higly demanding and cost - effective commercial applications

This work reviews the work made in last years to produce thermoplastic matrix towpregs to highly demanding and more cost-effective commercial applications using a powder coating technology developed in Portugal by Minho and Porto Universities. Different thermoplastic matrices and continuous fibre reinforcements were used in the towpregs produced for highly demanding markets (e.g., carbon fibre reinforced Primospire towpreg) and for more commercial applications (e.g., glass fibre reinforced polypropylene and polyvinyl chloride towpregs). The relevant processing parameters, such as, fibre pull-speed and furnace temperature were varied to determine their influence on the polymer mass fraction obtained in the studied raw materials. Several technologies were also developed and used (compression moulding, pultrusion and filament winding) to process composite parts with adequate properties for the envisaged markets at compatible production rates. The obtained results lead us to conclude that the studied thermoplastic matrix towpregs and their processed composite parts have very interesting conditions for being applied both in highly advanced and cost-effective markets.European Space Agency (ESA) e Fundação para a Ciência e a Tecnologia (FCT

Processing thermoplastic matrix towpregs by pultrusion

In this work glass fibre reinforced polypropylene (GF/PP) towpregs, continuously produced at different processing conditions in a dry powder coating equipment, were processed into final composites by using a developed prototype pultrusion equipment. The influence of the fibre pull-speed and furnace temperature used in the dry coating towpregger on the polymer content of final produced towpregs was determined. Optical microscopy and SEM were techniques also used to assess quality of the produced GF/PP towpregs. The GF/PP towpregs were then processed into a composite bar by using a prototype pultrusion machine that will be described and presented in the workshop. Studies were carried out to determine the influence of the pull-speed and temperatures used in the pultrusion heated and cooled dies on the mechanical and other relevant physical properties of final composite profiles. Finally, the final composite profiles processing window and optimisation will be discussed and presented

On the particle spectrum and the conformal window

We study the SU(3) gauge theory with twelve flavours of fermions in the fundamental representation as a prototype of non-Abelian gauge theories inside the conformal window. Guided by the pattern of underlying symmetries, chiral and conformal, we analyze the two-point functions theoretically and on the lattice, and determine the finite size scaling and the infinite volume fermion mass dependence of the would-be hadron masses. We show that the spectrum in the Coulomb phase of the system can be described in the context of a universal scaling analysis and we provide the nonperturbative determination of the fermion mass anomalous dimension gamma*=0.235(46) at the infrared fixed point. We comment on the agreement with the four-loop perturbative prediction for this quantity and we provide a unified description of all existing lattice results for the spectrum of this system, them being in the Coulomb phase or the asymptotically free phase. Our results corroborate the view that the fixed point we are studying is not associated to a physical singularity along the bare coupling line and estimates of physical observables can be attempted on either side of the fixed point. Finally, we observe the restoration of the U(1) axial symmetry in the two-point functions.Comment: 40 pages, 22 figure

Production of thermoplastic matrix towpregs for highly demanding and cost-effective commercial applications

This work reviews the work made in last years to produce thermoplastic matrix towpregs to highly demanding and more cost-effective commercial applications using a powder coating technology developed in Portugal by Minho and Porto Universities. Different thermoplastic matrices and continuous fibre reinforcements were used in the towpregs produced for highly demanding markets (e.g., carbon fibre reinforced Primospire towpreg) and for more commercial applications (e.g., glass fibre reinforced polypropylene and polyvinyl chloride towpregs). The relevant processing parameters, such as, fibre pull-speed and furnace temperature were varied to determine their influence on the polymer mass fraction obtained in the studied raw materials. Several technologies were also developed and used (compression moulding, pultrusion and filament winding) to process composite parts with adequate properties for the envisaged markets at compatible production rates. The obtained results lead us to conclude that the studied thermoplastic matrix towpregs and their processed composite parts have very interesting conditions for being applied both in highly advanced and cost-effective markets.The authors acknowledge the European Space Agency (ESA) and the Portuguese Foundation for Science and Technology (FCT) for the financial support given to the work carried on

One,Two,Zero: Scales of Strong Interactions

We discuss our results on QCD with a number of fundamental fermions ranging from zero to sixteen. These theories exhibit a wide array of fascinating phenomena which have been under close scrutiny, especially in recent years, first and foremost is the approach to conformality. To keep this review focused, we have chosen scale generation, or lack thereof as a guiding theme, however the discussion will be set in the general framework of the analysis of the phases and phase transitions of strong interactions at zero and nonzero temperature.Comment: 15 pages, prepared for IJMPA Special Issue 'Recent Nonperturbative Developments in QCD-like Theories

Chiral symmetry restoration in QCD with many flavours

We discuss the phases of QCD in the parameter space spanned by the number of light flavours and the temperature with respect to the realisation of chiral and conformal symmetries. The intriguing interplay of these symmetries is best studied by means of lattice simulations, and some selected results from our recent work are presented here.Comment: 10 pages, proceedings of the 9th International Workshop on Critical Point and Onset of Deconfinement, 17-21 November, 2014, ZiF, Bielefeld, German

Intra-abdominal infections: the role of different classifications on the selection of the best antibiotic treatment

The study was approved by the local ethics committee, Departamento de Ensino, Formação e Investigação (DEFI) of Centro Hospitalar Universitário do Porto (CHUP) - ref. 2017.226(195-DEFI/187-CES). The need for consent was waived by the local ethics committee and patient data was de-identifiedBackground: Intra-abdominal infections (IAIs) represent a most frequent gastrointestinal emergency and serious cause of morbimortality. A full classification, including all facets of IAIs, does not exist. Two classifications are used to subdivide IAIs: uncomplicated or complicated, considering infection extent; and community-acquired, healthcare-associated or hospital-acquired, regarding the place of acquisition. Adequacy of initial empirical antibiotic therapy prescribed is an essential need. Inadequate antibiotic therapy is associated with treatment failure and increased mortality. This study was designed to determine accuracy of different classifications of IAIs to identify infections by pathogens sensitive to current treatment guidelines helping the selection of the best antibiotic therapy. Methods: A retrospective cohort study including all adult patients discharged from hospital with a diagnosis of IAI between 1st of January and 31st of October, 2016. All variables potentially associated with pre-defined outcomes: infection by a pathogen sensitive to non-pseudomonal cephalosporin or ciprofloxacin plus metronidazole (ATB 1, primary outcome), sensitive to piperacillin-tazobactam (ATB 2) and hospital mortality (secondary outcomes) were studied through logistic regression. Accuracy of the models was assessed by area under receiver operating characteristics (AUROC) curve and calibration was tested using the Hosmer-Lemeshow goodness-of-fit test. Results: Of 1804 patients screened 154 met inclusion criteria. Sensitivity to ATB 1 was independently associated with male gender (adjusted OR = 2.612) and previous invasive procedures in the last year (adjusted OR = 0.424) (AUROC curve = 0,65). Sensitivity to ATB 2 was independently associated with liver disease (adjusted OR = 3.580) and post-operative infections (adjusted OR = 2.944) (AUROC curve = 0.604). Hospital mortality was independently associated with age ≥ 70 (adjusted OR = 4.677), solid tumour (adjusted OR = 3.127) and sensitivity to non-pseudomonal cephalosporin or ciprofloxacin plus metronidazole (adjusted OR = 0.368). The accuracy of pre-existing classifications to identify infection by a pathogen sensitive to ATB 1 was 0.59 considering place of acquisition, 0.61 infection extent and 0.57 local of infection, for ATB 2 it was 0.66, 0.50 and 0.57, respectively. Conclusion: None of existing classifications had a good discriminating power to identify IAIs caused by pathogens sensitive to current antibiotic treatment recommendations. A new classification, including patients' individual characteristics like those included in the current model, might have a higher potential to distinguish IAIs by resistant pathogens allowing a better choice of empiric antibiotic therapy.info:eu-repo/semantics/publishedVersio

Tilted boxes on inclined planes

We propose the study of a box placed on an inclined plane, with an initial tilt with respect to the plane. This is a paradigmatic example of the role played by friction as a link between translational and rotational motion. This example has two advantages over the usual example of a sphere (or cylinder) rolling down an inclined plane. First, it provides a good model for a much greater variety of "real-life" situations. Second, it exhibits a much richer structure in parameter space, even when the box starts from rest. (C) 2000 American Association of Physics Teachers

Potencial forrageiro da Brachiaria humidicola cv. Llanero (ex. B. dictyoneura) para a recria de equinos.

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