Search for supersymmetry via associated production of charginos and neutralinos in final states with three leptons

A search for associated production of charginos and neutralinos is performed using data recorded with the D0 detector at a p (p) over bar center-of-mass energy of 1.96 TeV at the Fermilab Tevatron Collider. This analysis considers final states with missing transverse energy and three charged leptons, of which at least two are electrons or muons. No evidence for supersymmetry is found in a data set corresponding to an integrated luminosity of 320 pb(-1). Limits on the product of the production cross section and leptonic branching fraction are set. For the minimal supergravity model, a chargino lower mass limit of 117 GeV at the 95% C.L. is derived in regions of parameter space with enhanced leptonic branching fractions

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk

Search for doubly charged Higgs boson pair production in the decay to mu(+)mu(+)mu(-)mu(-) in p(p)over-bar collisions at root s=1.96 TeV

A search for pair production of doubly charged Higgs bosons in the process p (p) over bar -->H++H---->mu(+)mu(+)mu(-)mu(-) is performed with the D0 run II detector at the Fermilab Tevatron. The analysis is based on a sample of inclusive dimuon data collected at an energy of roots=1.96 TeV, corresponding to an integrated luminosity of 113 pb(-1). In the absence of a signal, 95% confidence level mass limits of M(H-L(+/-+/-))>118.4 GeV/c(2) and M(H-R(+/-+/-))>98.2 GeV/c(2) are set for left-handed and right-handed doubly charged Higgs bosons, respectively, assuming 100% branching into muon pairs

Genetic resources of vegetable crops: a survey in the Brazilian germplasm collections pictured through papers published in the journals of the Brazilian Society for Horticultural Science Recursos genéticos de hortaliças: as atividades nas coleções brasileiras de germoplasma retratadas nas publicações da Associação Brasileira de Horticultura

The research on plant genetic resources is essential for the conservation of genetic diversity and accessions' divergence studies, as a basis for plant breeding. Aiming to know the state of art in this subject, a historical survey was carried out in Revista de Olericultura and in Horticultura Brasileira, from 1961 to 2006, searching for papers dealing with vegetable crops genetic resources. In each of the papers, the species studied, first author institution, publication year, applied software, number of accessions and descriptors, and the multivariate techniques used were registered. Based on these characteristics, papers were grouped using multivariate analysis. Sixty-one papers dealt somehow with genetic resources in the time covered by the survey, from which 91.8% were published after 1990 (60.7% from 2001 to 2005). The use of multivariate analysis was reported in 57.3% of the papers, with an average of 2.3 and maximum of 6 multivariate procedures per paper. The Tocher Method, reported in 34% of the papers, was the most frequently used multivariate analysis. Twenty-five species were studied. Capsicum was the most frequently studied genus, either considering number of papers (seven) or accessions (664). Research institutions located in the Southeast region concentrated the highest number of papers. UFV (Federal University of Viçosa), UENF (North Fluminense State University Darcy Ribeiro), Embrapa Vegetables, and UNESP (São Paulo State University) Campus of Jaboticabal responded for 45% of the papers. There was an improvement in the adequacy of the statistical techniques used along time, due mainly to the development of free-access software. The software Genes was the most frequently reported in the papers surveyed. Nevertheless, almost 50% of the authors did not mention the software used for data analysis. Quantitative morphoagronomic and evaluation descriptors were the most often used. The multivariate analysis allowed grouping the papers in nine clusters.<br>A pesquisa com recursos genéticos vegetais é essencial tanto para a conservação da diversidade genética, quanto para o estudo da divergência entre acessos, base para programas de melhoramento. Com objetivo de conhecer o estado-da-arte nesse tema, foram identificados os trabalhos relacionados a recursos genéticos de hortaliças publicados na " Revista de Olericultura" e " Horticultura Brasileira" , de 1961 a 2006. Foram anotadas as espécie(s) estudada(s), a instituição de origem do primeiro autor, o ano de publicação, os softwares utilizados, o número de acessos, o número de descritores e o número de técnicas multivariadas aplicadas em cada artigo. Com base nessas caraterísticas, os artigos foram agrupados utilizando análise multivariada. No período pesquisado, 61 artigos trataram, sob algum aspecto, de recursos genéticos. Desses, 91,8% foram publicados a partir de 1990, com concentração de 2001 a 2005 (60,7%), com 57,3% deles utilizando pelo menos uma técnica multivariada, com média de 2,3 e máximo de seis técnicas por artigo. O método de agrupamento de Tocher foi o mais utilizado, relatado em 34% dos artigos. Os artigos cobriram 25 espécies. Dentre elas, Capsicum foi o gênero mais pesquisado, tanto em relação ao número de artigos (sete), quanto em número de acessos estudados (664). As instituições de pesquisa da região Sudeste concentraram o maior número de artigos. Se somadas, UFV, UENF, Embrapa Hortaliças e UNESP Campus de Jaboticabal foram responsáveis por 45% dos trabalhos publicados no tema. Houve um aprimoramento das técnicas estatísticas utilizadas na análise dos dados, sobretudo devido ao desenvolvimento e uso de softwares de fácil compreensão. O programa GENES foi o mais referenciado. Entretanto, quase a metade dos autores não citou o programa estatístico utilizado para a análise dos dados. Os descritores de caracterização morfoagronômica quantitativos e de avaliação foram os mais estudados. A análise multivariada permitiu classificar os artigos em nove grupos