PACING OPPORTUNITIES AT HOME AND SKILL OF CHILDREN WITH POTENTIAL CHANGES IN FUNCTIONAL DEVELOPMENT

Introduction: the multifactorial nature of motor development is reinforced by the combination of biological and environmental risk factors, which intensify the chances of impaired motor development. Objectives: to verify the relationship between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. Methods: transversal study conducted with 112 patients aged 18-42 months from follow-up services. Motor stimulus opportunities were evaluated by the Affordance in the Home Environment for Motor Development (AHEMD-SR) and Functional mobility skills by the Pediatric Evaluation Disability Inventory (PEDI). Student t test and multiple linear regression analysis were carried out. Results: predominance of good performance of functional mobility skills and “average level” of environmental stimulus opportunities were observed. There was no significant association between HFM-PEDI and AHEMD-SR. The results showed significant association only between HFM-PEDI and presence of health problems (p = 0.004). Children with health problems had lower mean PEDI normative score. Multiple linear regression analysis showed significant result for health problems in the interaction among environment, control variables and HFM-PEDI (p = 0.003). Conclusion: there was no association between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. On the other hand, children with some health problem showed lower performance in functional mobility skills

Medidas de mitigação ao atropelamento de fauna em rodovias federais concedidas no Brasil

O desenvolvimento socioeconômico de diversos paí­ses está relacionado   expansão e manutenção da infraestrutura rodoviária. No Brasil, o modo rodoviário é o mais utilizado, todavia, as rodovias podem causar impactos negativos   biodiversidade, pois contribuem para a fragmentação de hábitats e a redução de fluxos biológicos. Dentre os principais impactos causados pelas rodovias, destaca-se o atropelamento da fauna, de forma que medidas de mitigação para esse impacto se tornam necessárias. Com base nos dados coletados até o ano de 2017, o presente estudo tem por objetivo apresentar informações quanto  s medidas mitigadoras ao atropelamento de fauna silvestre presentes nas rodovias federais concedidas do Brasil. Foram cadastradas 461 medidas de mitigação, mais 627 dispositivos de engenharia que podem ser utilizados como passagens, sendo que, desse total, 334 encontram-se nas proximidades de áreas legalmente protegidas. Existem 158 medidas em fase de planejamento para serem implementadas

Synergetic action of atorvastatin and fluconazole against fluconazole-resistant Candida albicans in vitro and in a murine model for intra-abdominal Candidiasis / Ação sinérgica da atorvastatina e fluconazol contra Candida albicans resistente ao fluconazol in vitro e em um modelo murino contra Candidíase intra-abdominal

Introduction: Candida albicans is the most common causative agent of Intra-abdominal Candidiasis (IAC) and it is resistant to most antifungal drugs currently available. Here we investigated atorvastatin in vitro and in vivo antifungal activities against a fluconazole-resistant C. albicans strain as a potential repurposed drug. The following tests were carried out: antifungal susceptibility tests to determine minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), determination of time-kill curve, biofilm assays, Candida albicans yeast-hyphae transition inhibition assay, murine model of Intra-abdominal candidiasis, survival curve, fungal load quantification, histopathology analysis, quantification of TNF-α and IL-17 cytokines, quantification of N-acetyl-β-D-glucosaminidase. In vitro assays showed the synergetic action of atorvastatin and fluconazole against C. albicans growth and biofilm maturation while the time-kill curve assay revealed their fungicidal effect after 24 h of treatment. When yeast-to-hyphae transition was assessed, the synergetic effect of atorvastatin and fluconazole reduced C. albicans filamentation significantly. In vivo tests showed that one of the most noticeable signs of IAC is the intense systemic inflammation. However, our survival curve test showed that despite being ill, animals exhibited little to no clinical signs of systemic inflammation when treatment included a combination of atorvastatin and fluconazole. Altogether, these findings suggest that atorvastatin could be feasibly used in the treatment fluconazole-resistant C. albicans strains, showing that drug repurposing is an important strategy when considering the limited number of antifungal drugs available for treatment in addition to financial hardship experienced in research and development of new antifungal drugs.

PACING OPPORTUNITIES AT HOME AND SKILL OF CHILDREN WITH POTENTIAL CHANGES IN FUNCTIONAL DEVELOPMENT

Introduction: the multifactorial nature of motor development is reinforced by the combination of biological and environmental risk factors, which intensify the chances of impaired motor development. Objectives: to verify the relationship between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. Methods: transversal study conducted with 112 patients aged 18-42 months from follow-up services. Motor stimulus opportunities were evaluated by the Affordance in the Home Environment for Motor Development (AHEMD-SR) and Functional mobility skills by the Pediatric Evaluation Disability Inventory (PEDI). Student t test and multiple linear regression analysis were carried out. Results: predominance of good performance of functional mobility skills and “average level” of environmental stimulus opportunities were observed. There was no significant association between HFM-PEDI and AHEMD-SR. The results showed significant association only between HFM-PEDI and presence of health problems (p = 0.004). Children with health problems had lower mean PEDI normative score. Multiple linear regression analysis showed significant result for health problems in the interaction among environment, control variables and HFM-PEDI (p = 0.003). Conclusion: there was no association between functional mobility skills of children with risk factors and motor stimulus opportunities in their home environment. On the other hand, children with some health problem showed lower performance in functional mobility skills

Medidas de mitigação ao atropelamento de fauna em rodovias federais concedidas no Brasil

O desenvolvimento socioeconômico de diversos paí­ses está relacionado   expansão e manutenção da infraestrutura rodoviária. No Brasil, o modo rodoviário é o mais utilizado, todavia, as rodovias podem causar impactos negativos   biodiversidade, pois contribuem para a fragmentação de hábitats e a redução de fluxos biológicos. Dentre os principais impactos causados pelas rodovias, destaca-se o atropelamento da fauna, de forma que medidas de mitigação para esse impacto se tornam necessárias. Com base nos dados coletados até o ano de 2017, o presente estudo tem por objetivo apresentar informações quanto  s medidas mitigadoras ao atropelamento de fauna silvestre presentes nas rodovias federais concedidas do Brasil. Foram cadastradas 461 medidas de mitigação, mais 627 dispositivos de engenharia que podem ser utilizados como passagens, sendo que, desse total, 334 encontram-se nas proximidades de áreas legalmente protegidas. Existem 158 medidas em fase de planejamento para serem implementadas