Spatial variability of nitrogen dioxide and formaldehydeand residential exposure of children in the industrial area of Viadana, Northern Italy

Chipboard production is a source of ambient air pollution. We assessed the spatial variability of outdoor pollutants and residentialexposure of children living in proximity to the largest chipboard industry in Italy and evaluated the reliability of exposureestimates obtained from a number of available models. We obtained passive sampling data on NO2and formaldehyde collectedby the Environmental Protection Agency of Lombardy region at 25 sites in the municipality of Viadana during 10 weeks (2017-2018) and compared NO2measurements with average weekly concentrations from continuous monitors. We compared interpo-lated NO2and formaldehyde surfaces with previous maps for 2010. We assessed the relationship between residential proximity tothe industry and pollutant exposures assigned using these maps, as well as other available countrywide/continental models basedon routine data on NO2, PM10, andPM2.5. The correlation between NO2concentrations from continuous and passive samplingwas high (Pearson'sr= 0.89), although passive sampling underestimated NO2especially during winter. For both 2010 and 2017-2018, we observed higher NO2and formaldehyde concentrations in the south of Viadana, with hot-spots in proximity to theindustry. PM10and PM2.5exposures were higher for children at 3.5 km to theindustry, whereas NO2exposure was higher at 1-1.7 km to the industry. Road and population densities were also higher close tothe industry. Findings from a variety of exposure models suggest that children living in proximity to the chipboard industry inViadana are more exposed to air pollution and that exposure gradients are relatively stable over time

Proximity to chipboard industries increases the risk of respiratory and irritation symptoms in children: the Viadana study

Emissions related to wood production processes are a recognized health hazard for professionally exposed subjects. The health effects of living close to wood industries are not known, particularly in the pediatric population. We aimed at investigating if living close to chipboard industries is a health hazard for the children in the Viadana district (Northern Italy). In December 2006, all the children (3-14 years) living in the Viadana district, where two big chipboard industries are located, were surveyed through a parental questionnaire (n=3854). The children were geocoded, and the distance of their houses/schools from the closest wood plant was computed. Independently of sex, age, nationality, residential area, traffic, parents' education, passive/parental smoking, questionnaire compiler and his/her environmental concern, the children living at <2 km from chipboard industries had a greater prevalence of respiratory (OR=1.33, 95%CI: 1.11, 1.60), cough/phlegm (OR=1.43, 95%CI: 1.08, 1.88), nose/throat/mouth (OR=1.47, 95%CI: 1.23, 1.75), eye (OR=1.24, 95%CI: 1.04, 1.48) symptoms, school-days lost (OR=1.24, 95%CI: 1.04, 1.48), and emergency (OR=2.14, 95%CI: 1.47, 3.11) and hospital (OR=2.21, 95%CI: 1.17, 4.18) admissions. There was an inverse dose-response relationship between the adverse health outcomes considered and the distance from the plants. The attributable fractions for the children living close to the chipboard industries were substantial, ranging from 13% (eye symptoms) to 27% (cough/phlegm). The present findings suggest that emissions from chipboard industries might have a serious impact on children's health status and should therefore be reduced and closely monitored

Proximity to wood industries and respiratory symptoms in children: a sensitivity analysis.

Increased prevalence of respiratory and irritation symptoms was found in children who live near a large wood industrial park. Proximity to the wood industries was used as indicator of exposure. This study describes a sensitivity analysis for the results of the survey. All the children (3-14 years) living in the area were surveyed through a parental questionnaire (n=3854) and their addresses were geocoded. The distances from each child's home and school to the closest industry were combined, weighted and used as an indicator of exposure. A sensitivity analysis was performed to check 1) the robustness of the results to the choice of weights used for defining the exposure indicator, 2) the effect of outliers on risk estimates and 3) the sensitivity on the functional form used for modeling the dose-response function. The choice of the weights did not influence the association between proximity to the industries and respiratory symptoms. Excluding the subjects who lived far away from the industries showed that in a radius of 5km from the industries the study did not had enough power to estimate a gradient in the dose-response function. Besides, results were sensitive to the choice of the functional form used for modeling the minimum distance. The sensitivity analyses confirmed the overall increasing trend of respiratory symptoms with proximity to the industries and pointed out that all the assumptions made for defining a proxy of exposure need to be carefully checked

Proximity to wood factories and hospitalizations for respiratory diseases in children

AbstractBACKGROUND:Exposure to air pollutants emitted by wood industries has been associated with increased prevalence of respiratory and irritation symptoms.OBJECTIVES:To study whether proximity to wood industries was associated with risk of hospitalization for respiratory diseases in children.METHODS:In December 2006, the large majority of the children (3-14 years) living in the Viadana district (Northern Italy) were surveyed through a parental questionnaire (n=3854). Hospital discharge records for respiratory diseases (2002-2006) were obtained from the local Health Unit. The children were geocoded and the distance from their home/school to the wood industries was used as exposure indicator. Poisson regression models were used to assess the association between the distance and hospitalizations.RESULTS:The hospitalization rates for respiratory diseases increased with proximity to the wood industries: they were 7.55 (95% CI 5.58, 10.22) 71000 person-year for those who lived far from any wood industry, 11.84 (95% CI 8.87, 15.81) 71000 person-year for those <2km from the small wood factories and 16.61 (95% CI: 13.57, 20.33) 71000 person-year for those living within 2km from the two big chipboard industries.CONCLUSIONS:Proximity to wood industries is associated with a higher risk of hospitalization for respiratory diseases and respiratory symptoms in children. Studies with direct measures of exposure are needed and a follow-up of exposed population is advisable

Confronto dell'esperienza di mortalit\ue0 per cause specifiche di popolazioni esposte e non esposte a fonti emissive esterne di formaldeide e polveri di legno: lo studio di Viadana.[Cause-specific mortality in populations exposed and unexposed to outdoor emissions of formaldehyde and wood dust: the Viadana study.]

AIM: to describe the mortality risk for all causes and chronic diseases among people living in the industrial district of Viadana (Mantua), where wooden furniture factories producing formaldehyde and wood dust are situated. DESIGN: mortality for the years 1996-2005 among residents in the conmunicipalities where the industrial plants are located (exposed areas) was compared with the mortality among people living in the areas without plants (non-exposed areas). Main outcomes: standardized mortality ratios (SMR), using as reference the total population of the Province of Mantua. RESULTS: overall mortality risk was slightly higher in the non-exposed areas and in the district of Viadana than in the Province of Mantua. Mortality risk for all cancers in the exposed areas was lower than in the Province of Mantua (SMR=0.93; 95% IC 0.87-0.99). Mortality for prostate cancer was significantly increased in the exposed areas compared to non-exposed areas (RR=1.83; 95% IC 1.08-3.09) and to the Province of Mantua as a whole (SMR=1.39; 95% IC 1.06-1.79). Mortality maps suggest a higher mortality risk for prostate cancer, mainly among exposed areas. An excess of mortality for leukaemia (non-statistically significant) and for respiratory diseases (statistically significant) was found in Gazzuolo and Sabbioneta, both located in the exposed area. CONCLUSION: no statistically significant excess risk of mortality for cancer of upper aerodigestive tract was found among residents in municipalities where wood dust and formaldehyde producing factories were active. The increased mortality risk for prostate cancer and leukaemia needs to be deeply analyzed

Residential exposure to air pollution and adverse respiratory and allergic outcomes in children and adolescents living in a chipboard industrial area of Northern Italy

BACKGROUND: Chipboard production is a source of wood dust, formaldehyde, and combustion-related pollutants such as nitrogen dioxide (NO(2)) and particulate matter (PM). In this cohort study, we assessed whether exposures to NO(2), formaldehyde, PM(10), PM(2.5), and black carbon were associated with adverse respiratory and allergic outcomes among all 7525 people aged 0-21 years residing in the Viadana district, an area in Northern Italy including the largest chipboard industrial park in the country. METHODS: Data on hospitalizations, emergency room (ER) admissions, and specialist visits in pneumology, allergology, ophthalmology, and otorhinolaryngology were obtained from the Local Health Unit. Residential air pollution concentrations in 2013 (baseline) were derived using local (Viadana II), national (EPISAT), and continental (ELAPSE) exposure models. Associations were estimated using negative binomial regression models for counts of events occurred during 2013-2017, with follow-up time as an offset term and adjustment for sex, age, nationality, and a census-block socio-economic indicator. RESULTS: Median annual exposures to NO(2), PM(10), and PM(2.5) were below the European Union annual air quality standards (40, 40, and 25 mug/m(3)) but above the World Health Organization 2021 air quality guideline levels (10, 15, and 5 mug/m(3)). Exposures to NO(2) and PM(2.5) were significantly associated with higher rates of ER pneumology admissions (13 to 30 % higher rates per interquartile range exposure differences, all p < 0.01). Higher rates of allergology and ophthalmology visits were found for participants exposed to higher pollutants' concentrations. When considering the 4-km buffer around the industries, associations with respiratory hospitalizations became significant, and associations with ER pneumology admissions, allergology and ophthalmology visits became stronger. Formaldehyde was not associated with the outcomes considered. CONCLUSION: Using administrative indicators of health effects a priori attributable to air pollution, we documented the adverse impact of long-term air pollution exposure in residential areas close to the largest chipboard industries in Italy. These findings, combined with evidence from previous studies, call for an action to improve air quality through preventive measures especially targeting emissions related to the industrial activities