A family of loss-tolerant quantum coin flipping protocols

We present a family of loss-tolerant quantum strong coin flipping protocols; each protocol differing in the number of qubits employed. For a single qubit we obtain a bias of 0.4, reproducing the result of Berl\'{i}n et al. [Phys. Rev. A 80, 062321 (2009)], while for two qubits we obtain a bias of 0.3975. Numerical evidence based on semi-definite programming indicates that the bias continues to decrease as the number of qubits is increased but at a rapidly decreasing rate

Using complete measurement statistics for optimal device-independent randomness evaluation

The majority of recent works investigating the link between non-locality and randomness, e.g. in the context of device-independent cryptography, do so with respect to some specific Bell inequality, usually the CHSH inequality. However, the joint probabilities characterizing the measurement outcomes of a Bell test are richer than just the degree of violation of a single Bell inequality. In this work we show how to take this extra information into account in a systematic manner in order to optimally evaluate the randomness that can be certified from non-local correlations. We further show that taking into account the complete set of outcome probabilities is equivalent to optimizing over all possible Bell inequalities, thereby allowing us to determine the optimal Bell inequality for certifying the maximal amount of randomness from a given set of non-local correlations.Comment: 12 pages, 4 figures. v2, v3, v4: minor corrections. See also the related independent work arXiv:1309.389

The EPR experiment in the energy-based stochastic reduction framework

We consider the EPR experiment in the energy-based stochastic reduction framework. A gedanken set up is constructed to model the interaction of the particles with the measurement devices. The evolution of particles' density matrix is analytically derived. We compute the dependence of the disentanglement rate on the parameters of the model, and study the dependence of the outcome probabilities on the noise trajectories. Finally, we argue that these trajectories can be regarded as non-local hidden variables.Comment: 11 pages, 5 figure

On the relation between Bell inequalities and nonlocal games

We investigate the relation between Bell inequalities and nonlocal games by presenting a systematic method for their bilateral conversion. In particular, we show that while to any nonlocal game there naturally corresponds a unique Bell inequality, the converse is not true. As an illustration of the method we present a number of nonlocal games that admit better odds when played using quantum resourcesComment: v3 changes: Updates to reflect PLA version. 1 examples changed. Physics Letters A (accepted for publication

Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force

Objectives: to establish whether review articles provide consistent conclusions on associations between workplace psychosocial factors and musculoskeletal pain and, if differences exist, to explore whether this is related to the methods used.Methods: reviews, reported up to February 2007, that included consideration of workplace psychosocial factors and upper limb, back or knee pain were identified through searches of multiple databases. The specific work-related psychosocial factors considered were job demands, support, job autonomy and job satisfaction. The conclusions of each review on one or more of the psychosocial/musculoskeletal pain associations were extracted.Results: 15 review articles were identified that considered one or more of the regional pain syndromes included in the study. For back pain, the most consistent conclusions (four reviews positive out of six) were with high job demands and low job satisfaction. The studies of upper limb pain were exclusively related to shoulder and/or neck pain, and the most consistent positive conclusions were with high and low job demands (four reviews positive out of six and two reviews positive out of three, respectively). For knee pain, only a single review was identified. For individual reviews of back and upper limb pain, there were marked differences in the number of associations concluded to be positive between reviews.Conclusions: the reasons for reviews coming to different conclusions included that they were often evaluating different bodies of evidence (according to their search criteria, the year when the review was conducted, the role that quality assessment played in whether studies contributed to evidence, and the combination of risk factors addressed in individual studies), but more important was whether the review specified explicit criteria for making conclusions on strength of evidence. These conclusions emphasise the importance of developing standardised methods for conducting such evaluations of existing evidence and the importance of new longitudinal studies for clarifying the temporal relationship between psychosocial factors and musculoskeletal pain in the workplac

Last Glacial Maximum in an Andean cloud forest environment (Eastern Cordillera, Bolivia): Comment and Reply

Whether the climate of tropical South America during the Last Glacial Maximum (LGM) was colder and drier or colder and wetter than present day has been widely debated. It is accepted, however, that the LGM in tropical South America was 2–9 °C colder than today (e.g., Betts and Ridgway, 1992; Bush et al., 2001). Without debating the merits of the following choices, if we assume a lapse rate in the LGM similar to the modern one of ~0.6 °C·100 m−1, then an intermediate cooling of 5 °C would lower the boundary between montane cloud forest and the overlying puna grasslands by ~800 or 900 m. Palynologists on both sides of the wet/dry debate have come to similar conclusions about forest-boundary lowering due to temperature decrease (reviewed by Flenley, 1998). In the Eastern Cordillera of Bolivia the modern puna–cloud forest boundary lies ~3400 m above sea level (masl). Ignoring any other environmental changes, LGM cooling would have lowered this boundary to 2500 or 2600 masl

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir

Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interventions and vaccines. The 2009 pandemic influenza virus (H1N1pdm09) induces mild to moderate respiratory disease in infected ferrets, following inoculation with 106 plaque-forming units (pfu) of virus. We have demonstrated that reducing the challenge dose to 102 pfu delays the onset of clinical signs by 1 day, and results in a modest reduction in clinical signs, and a less rapid nasal cavity innate immune response. There was also a delay in virus production in the upper respiratory tract, this was up to 9-fold greater and virus shedding was prolonged. Progression of infection to the lower respiratory tract was not noticeably delayed by the reduction in virus challenge. A dose of 104 pfu gave an infection that was intermediate between those of the 106 pfu and 102 pfu doses. To address the hypothesis that using a more authentic low challenge dose would facilitate a more sensitive model for antiviral efficacy, we used the well-known neuraminidase inhibitor, oseltamivir. Oseltamivir-treated and untreated ferrets were challenged with high (106 pfu) and low (102 pfu) doses of influenza H1N1pdm09 virus. The low dose treated ferrets showed significant delays in innate immune response and virus shedding, delayed onset of pathological changes in the nasal cavity, and reduced pathological changes and viral RNA load in the lung, relative to untreated ferrets. Importantly, these observations were not seen in treated animals when the high dose challenge was used. In summary, low dose challenge gives a disease that more closely parallels the disease parameters of human influenza infection, and provides an improved pre-clinical model for the assessment of influenza therapeutics, and potentially, influenza vaccines

FoldIndex©: a simple tool to predict whether a given protein sequence is intrinsically unfolded

Summary: An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex© has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein. Availability: FoldIndex© can be accessed at http://bioportal.weizmann.ac.il/fldbin/findex Contact: [email protected] Supplementary information: http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/suppl/Prilusky_200

climate change and biodiversity in Amazonia: a Late-Holocene perspective

Fire is an important and arguably unnatural component of many wet Amazonian and Andean forest systems. Soil charcoal has been used to infer widespread human use of landscapes prior to European Conquest. An analysis of Amazonian soil carbon records reveals that the records have distinct spatial and temporal patterns, suggesting that either fires were only set in moderately seasonal areas of Amazonia or that strongly seasonal and aseasonal areas are undersampled. Synthesizing data from 300 charcoal records, an age-frequency diagram reveals peaks of fire apparently coinciding with some periods of very strong El Niñ o activity. However, the El Niñ o record does not always provide an accurate prediction of fire timing, and a better match is found in the record of insolation minima. After the time of European contact, fires became much scarcer within Amazonia. In both the Amazonia and the Andes, modern fire pattern is strongly allied to human activity. On the flank of the Andes, forests that have never burned are being eroded by fire spreading downslope from grasslands. Species of these same forests are being forced to migrate upslope due to warming and will encounter a firm artificial fire boundary of human activity