Looking back: corticothalamic feedback and early visual processing

[Abstract] Although once regarded as a simple sensory relay on the way to the cortex, it is increasingly apparent that the thalamus has a role in the ongoing moment-by-moment processing of sensory input and in cognition. This involves extensive corticofugal feedback connections and the interplay of these with the local thalamic circuitry and the other converging inputs. Here, using the feline visual system as the primary model, some of the latest developments in this field are reviewed and placed in the perspective of an integrated view of system function. Cortical feedback mediated by ionotropic and metabotropic glutamate receptors, and effects mediated by the neuromodulator nitric oxide, all have a role in integrating the thalamic mechanism into the cortical circuit. The essential point is that the perspective of higher-level sensory mechanisms shifts and modulates the thalamic circuitry in ways that optimize abstraction of a meaningful representation of the external world. This review is part of the TINS special issue on The Neural Substrates of Cognition.Ministerio de Ciencia y Tecnología; BFI2002–320

Always returning: feedback and sensory processing in visual cortex and thalamus

[Abstract] Feedback projections are an integral part of the mammalian visual system. Although it is tempting to relegate them to a subsidiary role in visual processing, because their supposed latency and lag might appear to be unfavourable for an involvement in fast processing, this is a dangerous simplification. Certainly for the world in motion, feedback from higher motion areas can influence the transfer of ascending input when, or even before, the input arrives. Here, we consider the circuit formed by layer 6 feedback cells in the visual cortex and how this straddles the retinothalamic and thalamocortical transfer of visual input. We discuss its links to feedback from the cortical motion area MT (V5), and suggest that motion perception involves a dynamic interplay between MT, V1 and the thalamus. This review is part of the TINS special issue on The Neural Substrates of Cognition

Figure-ground modulation in awake primate thalamus

[Abstract] Figure-ground discrimination refers to the perception of an object, the figure, against a nondescript background. Neural mechanisms of figure-ground detection have been associated with feedback interactions between higher centers and primary visual cortex and have been held to index the effect of global analysis on local feature encoding. Here, in recordings from visual thalamus of alert primates, we demonstrate a robust enhancement of neuronal firing when the figure, as opposed to the ground, component of a motion-defined figure-ground stimulus is located over the receptive field. In this paradigm, visual stimulation of the receptive field and its near environs is identical across both conditions, suggesting the response enhancement reflects higher integrative mechanisms. It thus appears that cortical activity generating the higher-order percept of the figure is simultaneously reentered into the lowest level that is anatomically possible (the thalamus), so that the signature of the evolving representation of the figure is imprinted on the input driving it in an iterative process.Biotechnology and Biological Sciences Research Council (United Kingdom); G022305/1Medical Research Council, (United Kingdom); G070153

Corticothalamic interactions in the transfer of visual information.

Thalamic function does not stand apart, as a discrete processing step, from the cortical circuitry. The thalamus receives extensive feedback from the cortex and this influences the firing pattern, synchronization and sensory response mode of relay cells. A crucial question concerns the extent to which the feedback simply controls the state and transmission mode of relay cells and the extent to which the feedback participates in the specific processing of sensory information. Using examples from experiments examining the influence of feedback from the visual cortex to the lateral geniculate nucleus (LGN), we argue that thalamic mechanisms are selectively focused by visually driven feedback to optimize the thalamic contribution to segmentation and global integration. This involves effects on both the temporal and spatial parameters characterizing the responses of LGN cells and includes, for example, motion-driven feedback effects from MT (middle temporal visual area) relayed via layer 6 of V1 (primary visual cortex)