Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Amonia as an energy resource?

W rozdziale opisano podjęte próby wykorzystania amoniaku jako surowca energetycznego. Podano genezę nazwy amoniak. Opisano jego strukturę i dotychczasowe sposoby wykorzystania, wskazując na znaczącą rolę wodoru – także w cząsteczkach wody, metanu czy innych węglowodorów. Autorzy nawiązują do zmienionej japońskiej polityki energetycznej oraz mapy drogowej ,w której wodór, ale przede wszystkim amoniak, mają podstawową do spełnienia rolę. Pokazują rolę wodoru i produktów wodoropochodnych w wytwarzaniu energii. Japońska Mapa drogowa określa drogę dojścia do zero emisyjności gospodarki w perspektywie 2050 r. Wskazano także na bolączki infrastruktury przesyłowej i magazynowania wodoru wobec znacznie łatwiejszej logistyce dla amoniaku. Zaznaczono możliwą do wypełnienia rolę grafenu jako materiału do magazynowania wodoru. Opisano szanse i wyzwania stojące przed rozwojem transgranicznego rynku „zielonego” wodoru w UE. Jednocześnie pokazano podobieństwo w celu osiągnięcia neutralności klimatycznej Europy do 2050, której główne cele to brak emisji netto gazów cieplarnianych do atmosfery oraz doprowadzenie do oddzielenia wzrostu ekonomicznego od zasobów. Rola wodoru w założeniach tej polityki klimatycznej wydaje się nie do przecenienia. Ma on przede wszystkim zastąpić paliwa kopalne w tych sektorach, których nie da się w pełni zelektryfikować oraz pozwolić na magazynowanie energii elektrycznej wytworzonej z OZE w okresie nadpodaży.The chapter describes the attempts to use ammonia as an energy raw material. The origin of the name ammonia is given. Its structure and current methods of use have been described, indicating the significant role of hydrogen – also in water, methane and other hydrocarbons. The authors refer to the revised Japanese energy policy and the roadmap in which hydrogen, but above all ammonia, have a fundamental role to play. They show the role of hydrogen and hydrocarbon products in energy production. The Japanese roadmap outlines the path to a zero-carbon economy by 2050. It also points to the disadvantages of hydrogen transmission and storage infrastructure in the face of much easier logistics for ammonia. The possible role of graphene as a material for hydrogen storage is marked. The opportunities and challenges facing the development of the cross-border „green” hydrogen market in the EU are described. And the similarity is shown with the aim of achieving Europe’s climate neutrality by 2050, the main goals of which are no net emissions of greenhouse gases to the atmosphere and a decoupling of economic growth from resources. The role of hydrogen in the assumptions of this climate policy cannot be overestimated. It is primarily intended to replace fossil fuels in those sectors that cannot be fully electrified and allow the storage of electricity generated from RES in the period of oversupply