Spiral Complete Coverage Path Planning Based on Conformal Slit Mapping in Multi-connected Domains

Generating a smooth and shorter spiral complete coverage path in a multi-connected domain is an important research area in robotic cavity machining. Traditional spiral path planning methods in multi-connected domains involve a subregion division procedure; a deformed spiral path is incorporated within each subregion, and these paths within the subregions are interconnected with bridges. In intricate domains with abundant voids and irregular boundaries, the added subregion boundaries increase the path avoidance requirements. This results in excessive bridging and necessitates longer uneven-density spirals to achieve complete subregion coverage. Considering that conformal slit mapping can transform multi-connected regions into regular disks or annuluses without subregion division, this paper presents a novel spiral complete coverage path planning method by conformal slit mapping. Firstly, a slit mapping calculation technique is proposed for segmented cubic spline boundaries with corners. Then, a spiral path spacing control method is developed based on the maximum inscribed circle radius between adjacent conformal slit mapping iso-parameters. Lastly, the spiral path is derived by offsetting iso-parameters. The complexity and applicability of the proposed method are comprehensively analyzed across various boundary scenarios. Meanwhile, two cavities milling experiments are conducted to compare the new method with conventional spiral complete coverage path methods. The comparation indicate that the new path meets the requirement for complete coverage in cavity machining while reducing path length and machining time by 12.70% and 12.34%, respectively.Comment: This article has not been formally published yet and may undergo minor content change

Quantum Double Lock-in Amplifier

Quantum lock-in amplifier aims to extract an alternating signal within strong noise background by using quantum strategy. However, as the target signal usually has an unknown initial phase, we can't obtain the complete information of its amplitude, frequency and phase in a single lock-in measurement. Here, to overcome this challenge, we give a general protocol for achieving a quantum double lock-in amplifier and illustrate its realization. In analog to a classical double lock-in amplifier, our protocol is accomplished via two quantum mixers under orthogonal pulse sequences. The two orthogonal pulse sequences act the roles of two orthogonal reference signals in a classical double lock-in amplifier. Combining the output signals, the complete characteristics of the target signal can be obtained. As an example, we illustrate the realization of our quantum double lock-in amplifier via a five-level double-$\Lambda$ coherent population trapping system with $^{87}$Rb atoms, in which each $\Lambda$ structure acts as a quantum mixer and the two applied dynamical decoupling sequences take the roles of two orthogonal reference signals. Our numerical calculations show that the quantum double lock-in amplifier is robust against experimental imperfections, such as finite pulse length and stochastic noise. Our study opens an avenue for extracting complete characteristics of an alternating signal within strong noise background, which is beneficial for developing practical quantum sensing technologies

High strength mullite-bond SiC porous ceramics fabricated by digital light processing

Fabricating SiC ceramics via the digital light processing (DLP) technology is of great challenge due to strong light absorption and high refractive index of deep-colored SiC powders, which highly differ from those of resin, and thus significantly affect the curing performance of the photosensitive SiC slurry. In this paper, a thin silicon oxide (SiO2) layer was in-situ formed on the surface of SiC powders by pre-oxidation treatment. This method was proven to effectively improve the curing ability of SiC slurry. The SiC photosensitive slurry was fabricated with solid content of 55 vol% and viscosity of 7.77 Pa s (shear rate of 30 s-1). The curing thickness was 50 μm with exposure time of only 5 s. Then, a well-designed sintering additive was added to completely convert low-strength SiO2 into mullite reinforcement during sintering. Complexshaped mullite-bond SiC ceramics were successfully fabricated. The flexural strength of SiC ceramics sintered at 1550 °C in air reached 97.6 MPa with porosity of 39.2 vol%, as high as those prepared by spark plasma sintering (SPS) techniques.</p

Critical Role of Phosphorus in Hollow Structures Cobalt-Based Phosphides as Bifunctional Catalysts for Water Splitting

Cobalt phosphides electrocatalysts have great potential for water splitting, but the unclear active sides hinder the further development of cobalt phosphides. Wherein, three different cobalt phosphides with the same hollow structure morphology (CoP-HS, CoP-HS, CoP-HS) based on the same sacrificial template of ZIF-67 are prepared. Surprisingly, these cobalt phosphides exhibit similar OER performances but quite different HER performances. The identical OER performance of these CoP-HS in alkaline solution is attributed to the similar surface reconstruction to CoOOH. CoP-HS exhibits the best catalytic activity for HER among these CoP-HS in both acidic and alkaline media, originating from the adjusted electronic density of phosphorus to affect absorption–desorption process on H. Moreover, the calculated ΔG based on P-sites of CoP-HS follows a quite similar trend with the normalized overpotential and Tafel slope, indicating the important role of P-sites for the HER process. Moreover, CoP-HS displays good performance (cell voltage of 1.67 V at a current density of 50 mA cm) and high stability in 1 M KOH. For the first time, this work detailly presents the critical role of phosphorus in cobalt-based phosphides for water splitting, which provides the guidance for future investigations on transition metal phosphides from material design to mechanism understanding.W.Z. and N.H. contributed equally to this work. X.Z. and J.F. are grateful for the Research Foundation-Flanders (FWO) project (12ZV320N). Funding from National Natural Science Foundation of China (project No.: 22005250, 21776120, and 51901161) is appreciated. M.X. is grateful to the National Natural Science Foundation of China (project No.: 22179109). W.Z. is grateful to the China Scholarship Council (NO. 201808310068). W.G. is grateful to the China Scholarship Council (NO. 201806030189). S.X. is grateful to the China Scholarship Council. K.W. is grateful to the Oversea Study Program of Guangzhou Elite Project. Funding from the Research Foundation–Flanders (FWO) (project No.: G0B3218N) and Natural Science Foundation of Fujian Province, China (No.: 2018J01433) is acknowledged. ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project ECOCAT and subproject NANOGEN. ICN2 is supported by the Severo Ochoa program from Spanish MINECO (Grant No. SEV-2017-0706) and is funded by the CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science Ph.D. program. This work has received funding from the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No. 654360 NFFA-Europe. X.H. thanks China Scholarship Council for scholarship support (201804910551)

Clinical features and gene variation analysis of COQ8B nephropathy: Report of seven cases

ObjectiveCOQ8B nephropathy is a relatively rare autosomal recessive kidney disease characterized by proteinuria and a progressive deterioration of renal function, eventually leading to end-stage renal disease (ESRD). The objective is to study the characteristics and correlation between the genotype and the clinical phenotype of COQ8B nephropathy.MethodsThis is a retrospective study focusing on the clinical characteristics of seven COQ8B nephropathy patients diagnosed by gene sequencing. Basic clinical information, clinical manifestations, examinations, imaging, genomes, pathology, treatments, and prognosis of the patients were reviewed.ResultsOf the seven patients, two were male children and five were female children. The median age at the disease onset was 5 years and 3 months. The initial main clinical manifestations were proteinuria and renal insufficiency. Four patients had severe proteinuria, four had focal segmental glomerulosclerosis (FSGS) diagnosed by a renal biopsy, and two had nephrocalcinosis after an ultrasound was performed on them. There were no other clinical manifestations such as neuropathy, muscle atrophy, and so on in all of them. Their gene mutations were all exon variants, which were classified as heterozygous or homozygous variants by performing family verification analysis. Compound heterozygous variants were predominant in all, and all gene variants were inherited from their parents. One novel mutation, c.1465c&gt;t, was found in this study. This gene mutation resulted from changes in the amino acid sequence, thus leading to an abnormal protein structure. Two patients with early diagnosis of COQ8B nephropathy presented with no renal insufficiency and were treated with oral coenzyme Q10 (CoQ10), and they maintained normal renal function. For the remaining five who were treated with CoQ10 following renal insufficiency, the deterioration of renal function could not be reversed, and they progressed to ESRD within a short time (median time: 7 months). A follow-up of these patients showed normal renal function with a CoQ10 supplement.ConclusionFor unexplained proteinuria, renal insufficiency, or steroid-resistant nephrotic syndrome, gene sequencing should be considered, in addition to renal biopsy, as early as possible. Timely diagnosis of COQ8B nephropathy and early supplementation of sufficient CoQ10 can help control the progression of the disease and significantly improve the prognosis

Newly formed dust within the circumstellar environment of SN Ia-CSM 2018evt

Dust associated with various stellar sources in galaxies at all cosmic epochs remains a controversial topic, particularly whether supernovae play an important role in dust production. We report evidence of dust formation in the cold, dense shell behind the ejecta–circumstellar medium (CSM) interaction in the Type Ia-CSM supernova (SN) 2018evt three years after the explosion, characterized by a rise in mid-infrared emission accompanied by an accelerated decline in the optical radiation of the SN. Such a dust-formation picture is also corroborated by the concurrent evolution of the profiles of the Hα emission line. Our model suggests enhanced CSM dust concentration at increasing distances from the SN as compared to what can be expected from the density profile of the mass loss from a steady stellar wind. By the time of the last mid-infrared observations at day +1,041, a total amount of 1.2 ± 0.2 × 10−2 M⊙ of new dust has been formed by SN 2018evt, making SN 2018evt one of the most prolific dust factories among supernovae with evidence of dust formation. The unprecedented witness of the intense production procedure of dust may shed light on the perceptions of dust formation in cosmic history

Impact of plant-based foods and nutraceuticals on toxoplasma gondii cysts: nutritional therapy as a viable approach for managing chronic brain toxoplasmosis

Toxoplasma gondii is an obligate intracellular parasite that mainly infects warm-blooded animals including humans. T. gondii can encyst and persist chronically in the brain, leading to a broad spectrum of neurological sequelae. Despite the associated health threats, no clinical drug is currently available to eliminate T. gondii cysts. In a continuous effort to uncover novel therapeutic agents for these cysts, the potential of nutritional products has been explored. Herein, we describe findings from in vitro and in vivo studies that support the efficacy of plant-based foods and nutraceuticals against brain cyst burden and cerebral pathologies associated with chronic toxoplasmosis. Finally, we discuss strategies to increase the translatability of preclinical studies and nutritional products to address whether nutritional therapy can be beneficial for coping with chronic T. gondii infections in humans.Ministry of Education (MOE)Published versionThis work was financially supported by the Ministry of Education, Singapore (grant RG136/15) and Human Frontier Science Programme (grant RGP0062/2018)

Impaired episodic-like memory in a mouse model of Alzheimer's disease is associated with hyperactivity in prefrontal–hippocampal regions

Alzheimer's disease (AD) is a degenerative brain disorder with a long prodromal period. An APPNL-G-F knock-in mouse model is a preclinical model to study incipient pathologies during the early stages of AD. Despite behavioral tests revealing broad cognitive deficits in APPNL-G-F mice, detecting these impairments at the early disease phase has been challenging. In a cognitively demanding task that assessed episodic-like memory, 3-month-old wild-type mice could incidentally form and retrieve 'what-where-when' episodic associations of their past encounters. However, 3-month-old APPNL-G-F mice, corresponding to an early disease stage without prominent amyloid plaque pathology, displayed impairment in recalling 'what-where' information of past episodes. Episodic-like memory is also sensitive to the effect of age. Eight-month-old wild-type mice failed to retrieve conjunctive 'what-where-when' memories. This deficit was also observed in 8-month-old APPNL-G-F mice. c-Fos expression revealed that impaired memory retrieval in APPNL-G-F mice was accompanied by abnormal neuronal hyperactivity in the medial prefrontal cortex and CA1 dorsal hippocampus. These observations can be used for risk stratification during preclinical AD to detect and delay the progression into dementia.Ministry of Education (MOE)Nanyang Technological UniversityPublished versionThis research was supported by the Ministry of Education - Singapore, under its AcRF Tier 3, MOE2017-T3-1-002. Open Access funding provided by Nanyang Technological University

Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor

Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain. In wild animals, chronic infection is associated with behavioral manipulation evident by an altered risk perception towards predators. In humans, reactivation of cysts and conversion of quiescent parasites into highly invasive tachyzoites is a significant cause of mortality in immunocompromised patients. However, the current standard therapy for toxoplasmosis is not well tolerated and is ineffective against the parasite cysts. In recent years, the concept of dietary supplementation with natural products derived from plants has gained popularity as a natural remedy for brain disorders. Notably, urolithin-A, a metabolite produced in the gut following consumption of ellagitannins-enriched food such as pomegranate, is reported to be blood-brain barrier permeable and exhibits neuroprotective effects in-vivo. In this study, we investigated the potential of pomegranate extract and urolithin-A as anti-neurotoxoplasmosis agents in-vitro and in-vivo. Treatment with pomegranate extract and urolithin-A reduced the parasite tachyzoite load and interfered with cyst development in differentiated human neural culture. Administration of urolithin-A also resulted in the formation of smaller brain cysts in chronically infected mice. Interestingly, this phenomenon was mirrored by an enhanced risk perception of the UA-treated infected mice towards predatory cues. Together, our findings demonstrate the potential of dietary supplementation with urolithin-A-enriched food as a novel natural remedy for the treatment of acute and chronic neurotoxoplasmosis