The Effects of Anterior Cruciate Ligament Thickness, Knee Joint Laxity, Activity Level, Neuromuscular Imbalances and Lower Extremity Muscular Activation Patterns on Anterior Cruciate Ligament Loading

There are numerous known mechanisms of anterior cruciate ligament (ACL) injury risk that span from knee joint laxity to landing mechanics. However, the relationship of these mechanisms to ACL loading during landing is unclear. In addition to landing mechanics, anthropological aspects such as ACL diameter, which can now be obtained via ultrasound, may also be an important mechanism for ACL loading. However, the relationship between ACL diameter to ACL loading and landing mechanics remains unknown. This study was conducted with three primary purposes. The first purpose of this study was to examine the inter and intra-rater reliability of using ultrasound to measure the diameter of the full ACL and anteromedial bundle of the ACL. The second purpose was to examine the relationship between the anteromedial bundle diameter and lower extremity strength, whole body anthropometrics, and previous physical activity levels. The third purpose was to examine the relationship between simulated ACL loading and pre-activation electromyography of lower extremity muscles, anteromedial bundle diameter and knee joint laxity. Two separate raters with differing levels of experience (low: Rater 1 and moderate: Rater 2) used diagnostic ultrasound to image bilateral ACLs of twenty participants. Rater 1 also performed an additional imaging session with the same population. Interclass correlations were conducted to examine 1) intra-rater reliability between sessions for Rater 1 and 2) inter-rater reliability between the Raters 1 and 2. To address the second purpose of this study, anteromedial bundle diameter, height, weight, strength measurements of the knee flexors, knee extensors, hip abductors, and hip adductors and previous physical activity were recorded for 17 participants. Pearson product correlations were conducted between anteromedial bundle diameter and the recorded variables. To address the third purpose of this study, 17 participants\u27 pre-activation of lower extremity muscles, anteromedial bundle diameter and passive knee joint laxity were recorded. Next, participants performed single leg landings from a 40 cm height and a height equal to their maximal jumping capabilities. During landings, three dimensional kinematic and kinetic variables were recorded as well as electromyography (EMG) of the Rectus Femoris, Vastus Medialis, Vastus Lateralis, Medial Hamstring, Lateral Hamstring, Medial Gastrocnemius, and Gluteus Medius. Participant specific musculoskeletal models were generated for each participant. Three dimensional ACL loading was calculated using previously established equations. Pearson product correlations were then utilized to analyze the relationship of ACL loading to knee joint laxity, anteromedial bundle diameter and pre-activation of the lower extremity muscles. Moderate correlations were found for inter and intra-rater reliabilities. There were weak correlations found for the full ACL diameter during inter and intra-rater analyses. The current results show that the anteromedial bundle can be found and measured more reliably than the full ACL. There were no significant correlations between anteromedial bundle diameter and previous exercise activity levels. However, significant correlations were found with quadriceps and adductor strength values. Simulated ACL loading was only found to have significant correlations with lateral hamstring pre-activation for both 40 cm and relative drop landing heights. The current results suggest that the pre-activation of the hamstrings may influence ACL loading if the medial and lateral hamstring groups are activated disproportionately. The results from these studies establish that the anteromedial bundle can be analyzed with moderate reliability from researchers utilizing ultrasound. Future research involving diagnostic ultrasound should consider analyzing the anteromedial bundle to increase reliability and generalizability of their results. Although it may be possible for stressors to cause hypertrophy in the ACL, few factors known to stress the ACL are significantly associated with the size of the anteromedial bundle diameter. Thus, the association between those mechanisms and ACL loading may not be as clear

Effects of Gait Speed of Femoroacetabular Joint Forces

Alterations in hip joint loading have been associated with diseases such as arthritis and osteoporosis. Understanding the relationship between gait speed and hip joint loading in healthy hips may illuminate changes in gait mechanics as walking speed deviates from preferred. The purpose of this study was to quantify hip joint loading during the gait cycle and identify differences with varying speed using musculo skeletal modeling. Ten, healthy, physically active individuals performed walking trials at their preferred speed, 10% faster, and 10% slower. Kinematic, kinetic, and electromyographic data were collected and used to estimate hip joint force via a musculoskeletal model. Vertical ground reaction forces, hip joint force planar components, and the resultant hip joint force were compared between speeds. There were significant increases in vertical ground reaction forces and hip joint forces as walking speed increased. Furthermore, the musculoskeletal modeling approach employed yielded hip joint forces that were comparable to previous simulation studies and in vivo measurements and was able to detect changes in hip loading due to small deviations in gait speed. Applying this approach to pathological and aging populations could identify specific areas within the gait cycle where force discrepancies may occur which could help focus management of care

Wearing Knee Sleeves During Back Squats Does Not Improve Mass Lifted or Affect Knee Biomechanics

Purpose:Knee sleeves have become widely popular in the exercise realm, especially for knee support during back squats. Knee sleeves are successful in providing frontal plane knee support during functional tasks, but have not been investigated in back squats. Knee wraps, a somewhat similar elastic material, provide elastic energy that increases weight lifted during back squats. Thus, it is possible the thick neoprene knee sleeves could prove advantageous for back squats. The purpose of this study was to examine the effects of knee sleeves on weight lifted, knee biomechanics, and muscle activations during back squats.Methods:Fifteen resistance trained men and women performed 1-repetition maximum (1-RM) squats to full depth and 80% 1-RM to full and parallel depths during two separate randomized sessions: with/without knee sleeves. Three-dimensional motion capture, force platforms, and electromyography recorded knee biomechanics and activations of the rectus femoris, vastus medialis, biceps femoris long head, and gluteus maximus during all squats.Results:Maximal weight lifted did not improve when using knee sleeves. Frontal plane knee biomechanics did not differ for 1-RM or submaximal squats to either depth between conditions. Knee external rotation moments during descent were larger with sleeves during submaximal squats. Reduced integrated ascent phase gluteus maximus activations occurred during both 1-RM and submaximal squats with knee sleeves.Conclusions:The results of this study show that wearing knee sleeves does not provide additive effects to weight lifted and do not appear to alter frontal plane mechanics during weighted back squats

The U.S. Inland Creel and Angler Survey Catalog (CreelCat): Development, Applications, and Opportunities

Inland recreational fishing, defined as primarily leisure-driven fishing in freshwaters, is a popular pastime in the USA. State natural resource agencies endeavor to provide high-quality and sustainable fishing opportunities for anglers. Managers often use creel and other angler survey data to inform state- and waterbody-level management efforts. Despite the broad implementation of angler surveys and their importance to fisheries management at state scales, regional and national coordination among these activities is minimal, limiting data applicability for larger-scale management practices and research. Here, we introduce the U.S. Inland Creel and Angler Survey Catalog (CreelCat), a first-of-its-kind, publicly available national database of angler survey data that establishes a baseline of national inland recreational fishing metrics. We highlight research and management applications to help support sustainable inland recreational fishing practices, consider cautions, and make recommendations for implementation

The khmer software package: enabling efficient nucleotide sequence analysis [version 1; referees: 2 approved, 1 approved with reservations]

The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/

Predicting Academic Performance: A Systematic Literature Review

The ability to predict student performance in a course or program creates opportunities to improve educational outcomes. With effective performance prediction approaches, instructors can allocate resources and instruction more accurately. Research in this area seeks to identify features that can be used to make predictions, to identify algorithms that can improve predictions, and to quantify aspects of student performance. Moreover, research in predicting student performance seeks to determine interrelated features and to identify the underlying reasons why certain features work better than others. This working group report presents a systematic literature review of work in the area of predicting student performance. Our analysis shows a clearly increasing amount of research in this area, as well as an increasing variety of techniques used. At the same time, the review uncovered a number of issues with research quality that drives a need for the community to provide more detailed reporting of methods and results and to increase efforts to validate and replicate work.Peer reviewe

Effects of Gait Speed of Femoroacetabular Joint Forces

Alterations in hip joint loading have been associated with diseases such as arthritis and osteoporosis. Understanding the relationship between gait speed and hip joint loading in healthy hips may illuminate changes in gait mechanics as walking speed deviates from preferred. The purpose of this study was to quantify hip joint loading during the gait cycle and identify differences with varying speed using musculoskeletal modeling. Ten, healthy, physically active individuals performed walking trials at their preferred speed, 10% faster, and 10% slower. Kinematic, kinetic, and electromyographic data were collected and used to estimate hip joint force via a musculoskeletal model. Vertical ground reaction forces, hip joint force planar components, and the resultant hip joint force were compared between speeds. There were significant increases in vertical ground reaction forces and hip joint forces as walking speed increased. Furthermore, the musculoskeletal modeling approach employed yielded hip joint forces that were comparable to previous simulation studies and in vivo measurements and was able to detect changes in hip loading due to small deviations in gait speed. Applying this approach to pathological and aging populations could identify specific areas within the gait cycle where force discrepancies may occur which could help focus management of care

Comparing anterior cruciate ligament injury risk variables between unanticipated cutting and decelerating tasks

To examine the relationship between anterior cruciate ligament injury risk factors in unanticipated cutting and decelerating. Three-dimensional kinematics and ground reaction forces were collected on 11 females (22 [2] y, 1.67 [0.08] m, and 68.5 [9.8] kg) during 2 unanticipated tasks. Paired samples t tests were performed to compare dependent variables between tasks. Spearman rank correlation coefficients were calculated to analyze the relationship between peak internal knee adduction moment and peak anterior tibial shear force (ASF) during 2 unanticipated tasks. Significantly greater knee abduction angles, peak knee adduction moments, and peak ASFs were observed during cutting (P ≤ .05). A strong positive correlation existed between decelerating ASF and cutting ASF (ρ = .67), while correlations between decelerating knee adduction moment and cutting knee adduction moment and decelerating ASF and cutting knee adduction moment were not significant. In situations where time management is a necessity and only one task can be evaluated, it may be more appropriate to utilize an unanticipated cutting task rather than an unanticipated deceleration task because of the increased knee adduction moment and ASF. These data can help future clinicians in better designing more effective anterior cruciate ligament injury risk screening methods

The khmer software package: enabling efficient nucleotide sequence analysis [version 1; referees: 2 approved, 1 approved with reservations]

The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/