49 research outputs found
Mangi – co każdy bibliotekarz wiedzieć powinien
The article presents basic informations about Japanese comics (manga), including it’s history, present, classification and correlations with Japanese animations (anime). It shows also the characteristics of Polish manga market and manga & anime fans in Poland and Japan.W artykule zaprezentowano podstawowe informacje na temat japońskich komiksów (mang), uwzględniając historię, współczesność, klasyfikację oraz korelacje z japońską animacją (anime). Zwrócono szczególną uwagę na polski rynek mangowy i charakterystykę wydawnictw. Opisano środowisko miłośników mangi i anime w Japonii i Polsce
A veritable zoology of successive phase transitions in the asymmetric -voter model on multiplex networks
We analyze a nonlinear -voter model with stochastic noise, interpreted in
the social context as independence, on a duplex network. The size of the lobby
(i.e., the pressure group) is a crucial parameter that changes the behavior
of the system. The -voter model has been applied on multiplex networks in a
previous work [Phys. Rev E. 92. 052812. (2015)], and it has been shown that the
character of the phase transition depends on the number of levels in the
multiplex network as well as the value of . Here we study phase transition
character in the case when on each level of the network the lobby size is
different, resulting in two parameters and . We find evidence of
successive phase transitions when a continuous phase transition is followed by
a discontinuous one or two consecutive discontinuous phases appear, depending
on the parameter. When analyzing this system, we even encounter mixed-order (or
hybrid) phase transition. We perform simulations and obtain supporting
analytical solutions on a simple multiplex case - a duplex clique, which
consists of two fully overlapped complete graphs (cliques).Comment: 13 pages, 10 figure
Universal scaling of distances in complex networks
Universal scaling of distances between vertices of Erdos-Renyi random graphs,
scale-free Barabasi-Albert models, science collaboration networks, biological
networks, Internet Autonomous Systems and public transport networks are
observed. A mean distance between two nodes of degrees k_i and k_j equals to
=A-B log(k_i k_j). The scaling is valid over several decades. A simple
theory for the appearance of this scaling is presented. Parameters A and B
depend on the mean value of a node degree _nn calculated for the nearest
neighbors and on network clustering coefficients.Comment: 4 pages, 3 figures, 1 tabl
Higher order clustering coefficients in Barabasi-Albert networks
Higher order clustering coefficients are introduced for random
networks. The coefficients express probabilities that the shortest distance
between any two nearest neighbours of a certain vertex equals , when one
neglects all paths crossing the node . Using we found that in the
Barab\'{a}si-Albert (BA) model the average shortest path length in a node's
neighbourhood is smaller than the equivalent quantity of the whole network and
the remainder depends only on the network parameter . Our results show that
small values of the standard clustering coefficient in large BA networks are
due to random character of the nearest neighbourhood of vertices in such
networks.Comment: 10 pages, 4 figure
Induction and maintenance infliximab therapy for the treatment of Crohn's disease with perianal fistulas in children : retrospective, multicenter study
Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.
HIV-1 encodes four "accessory proteins" (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and Nef, which counteract host restriction and promote viral replication. Conversely, although several substrates of Vpr have been described, their biological significance remains unclear. Here, we use complementary unbiased mass spectrometry-based approaches to demonstrate that Vpr is both necessary and sufficient for the DCAF1/DDB1/CUL4 E3 ubiquitin ligase-mediated degradation of at least 38 cellular proteins, causing systems-level changes to the cellular proteome. We therefore propose that promiscuous targeting of multiple host factors underpins complex Vpr-dependent cellular phenotypes and validate this in the case of G2/M cell cycle arrest. Our model explains how Vpr modulates so many cell biological processes and why the functional consequences of previously described Vpr targets, identified and studied in isolation, have proved elusive.This work was supported by the Wellcome Trust (PRF 210688/Z/18/Z to PJL), the MRC (CSF MR/P008801/1 to NJM), NHSBT (WPA15-02 to NJM), the NIHR Cambridge BRC, and a Wellcome Trust Strategic Award to the CIMR
Antisense Inhibition of the 2-Oxoglutarate Dehydrogenase Complex in Tomato Demonstrates Its Importance for Plant Respiration and during Leaf Senescence and Fruit Maturation
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A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Abstract: Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for complex stability and function. C18orf8-deficient cells lack Rab7 activation and show severe defects in late endosome morphology and endosomal LDL trafficking, resulting in cellular cholesterol deficiency. Unexpectedly, free cholesterol accumulates within swollen lysosomes, suggesting a critical defect in lysosomal cholesterol export. We find that active Rab7 interacts with the NPC1 cholesterol transporter and licenses lysosomal cholesterol export. This process is abolished in C18orf8-, Ccz1- and Mon1A/B-deficient cells and restored by a constitutively active Rab7. The trimeric Mon1-Ccz1-C18orf8 (MCC) GEF therefore plays a central role in cellular cholesterol homeostasis coordinating Rab7 activation, endosomal LDL trafficking and NPC1-dependent lysosomal cholesterol export