Mangi – co każdy bibliotekarz wiedzieć powinien

The article presents basic informations about Japanese comics (manga), including it’s history, present, classification and correlations with Japanese animations (anime). It shows also the characteristics of Polish manga market and manga & anime fans in Poland and Japan.W artykule zaprezentowano podstawowe informacje na temat japońskich komiksów (mang), uwzględniając historię, współczesność, klasyfikację oraz korelacje z japońską animacją (anime). Zwrócono szczególną uwagę na polski rynek mangowy i charakterystykę wydawnictw. Opisano środowisko miłośników mangi i anime w Japonii i Polsce

A veritable zoology of successive phase transitions in the asymmetric qq-voter model on multiplex networks

We analyze a nonlinear $q$-voter model with stochastic noise, interpreted in the social context as independence, on a duplex network. The size of the lobby $q$ (i.e., the pressure group) is a crucial parameter that changes the behavior of the system. The $q$-voter model has been applied on multiplex networks in a previous work [Phys. Rev E. 92. 052812. (2015)], and it has been shown that the character of the phase transition depends on the number of levels in the multiplex network as well as the value of $q$. Here we study phase transition character in the case when on each level of the network the lobby size is different, resulting in two parameters $q_1$ and $q_2$. We find evidence of successive phase transitions when a continuous phase transition is followed by a discontinuous one or two consecutive discontinuous phases appear, depending on the parameter. When analyzing this system, we even encounter mixed-order (or hybrid) phase transition. We perform simulations and obtain supporting analytical solutions on a simple multiplex case - a duplex clique, which consists of two fully overlapped complete graphs (cliques).Comment: 13 pages, 10 figure

Universal scaling of distances in complex networks

Universal scaling of distances between vertices of Erdos-Renyi random graphs, scale-free Barabasi-Albert models, science collaboration networks, biological networks, Internet Autonomous Systems and public transport networks are observed. A mean distance between two nodes of degrees k_i and k_j equals to =A-B log(k_i k_j). The scaling is valid over several decades. A simple theory for the appearance of this scaling is presented. Parameters A and B depend on the mean value of a node degree _nn calculated for the nearest neighbors and on network clustering coefficients.Comment: 4 pages, 3 figures, 1 tabl

Higher order clustering coefficients in Barabasi-Albert networks

Higher order clustering coefficients $C(x)$ are introduced for random networks. The coefficients express probabilities that the shortest distance between any two nearest neighbours of a certain vertex $i$ equals $x$, when one neglects all paths crossing the node $i$. Using $C(x)$ we found that in the Barab\'{a}si-Albert (BA) model the average shortest path length in a node's neighbourhood is smaller than the equivalent quantity of the whole network and the remainder depends only on the network parameter $m$. Our results show that small values of the standard clustering coefficient in large BA networks are due to random character of the nearest neighbourhood of vertices in such networks.Comment: 10 pages, 4 figure

Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection.

HIV-1 encodes four "accessory proteins" (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and Nef, which counteract host restriction and promote viral replication. Conversely, although several substrates of Vpr have been described, their biological significance remains unclear. Here, we use complementary unbiased mass spectrometry-based approaches to demonstrate that Vpr is both necessary and sufficient for the DCAF1/DDB1/CUL4 E3 ubiquitin ligase-mediated degradation of at least 38 cellular proteins, causing systems-level changes to the cellular proteome. We therefore propose that promiscuous targeting of multiple host factors underpins complex Vpr-dependent cellular phenotypes and validate this in the case of G2/M cell cycle arrest. Our model explains how Vpr modulates so many cell biological processes and why the functional consequences of previously described Vpr targets, identified and studied in isolation, have proved elusive.This work was supported by the Wellcome Trust (PRF 210688/Z/18/Z to PJL), the MRC (CSF MR/P008801/1 to NJM), NHSBT (WPA15-02 to NJM), the NIHR Cambridge BRC, and a Wellcome Trust Strategic Award to the CIMR

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Abstract: Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 guanidine exchange factor (GEF) for Rab7, required for complex stability and function. C18orf8-deficient cells lack Rab7 activation and show severe defects in late endosome morphology and endosomal LDL trafficking, resulting in cellular cholesterol deficiency. Unexpectedly, free cholesterol accumulates within swollen lysosomes, suggesting a critical defect in lysosomal cholesterol export. We find that active Rab7 interacts with the NPC1 cholesterol transporter and licenses lysosomal cholesterol export. This process is abolished in C18orf8-, Ccz1- and Mon1A/B-deficient cells and restored by a constitutively active Rab7. The trimeric Mon1-Ccz1-C18orf8 (MCC) GEF therefore plays a central role in cellular cholesterol homeostasis coordinating Rab7 activation, endosomal LDL trafficking and NPC1-dependent lysosomal cholesterol export

Totally implantable venous ports in infants and children: a single-center retrospective study of indications and safety

IntroductionTotally Implantable Venous Access Devices (TIVADs) contribute significantly to the treatment progress and comfort of patients requiring long-term therapy. However, the procedure for implanting TIVADs, as well as its very presence, may be associated with complications.AimThis study evaluates the indications, safety, and complication rates of venous port implantations in pediatric patients. It also explores factors influencing the occurrence of early and late complications post-implantation.Materials and methodsThe study included 383 pediatric patients treated at the Department of Pediatric Surgery, Traumatology, and Urology in Poznan between 2013 and 2020 who underwent 474 implantations of intravenous ports. Venous access was achieved using the Seldinger technique. Statistical analysis was performed using Statistica 13 with TIBCO and PQStat 1.8.2.156 with PQStat.ResultsVenous ports were used in 345 oncology patients requiring chemotherapy (90% of the total group) and in 38 children (10%) with non-oncology indications. There were 36 early complications (7.6%) and 18 late complications (3.8%), excluding infectious complications. The most common early, non-infectious complications included pneumothorax (15 patients; 3%) and port pocket hematoma (12 patients; 2.5%). The most common late, non-infectious complications observed were venous catheter obstruction (8 children; 1.7%) and port system leakage (5 children; 1%). Infectious complications occurred in 129 cases (27.2%). Children with a diagnosis of non-Hodgkin’s lymphoma, acute myeloid leukemia, and acute lymphoblastic leukemia had a significantly higher incidence of port infections. Venous ports equipped with a polyurethane catheter, compared to systems with a silicone catheter, functioned significantly shorter.ConclusionsThe Seldinger method of port implantation is quick, minimally invasive, and safe. The type of port, including the material of the port’s venous catheter, and the underlying disease have an impact on the durability of implantable intravenous systems. The experience of the surgeon is related to the frequency of complications associated with the procedure