A variable neurodegenerative phenotype with polymerase gamma mutation

mtDNA replication and repair, causes mitochondrial diseases including autosomal dominant progressive external ophthalmoplegia (PEO),1 childhood hepato-encephalopathy (Alpers– Huttenlocher syndrome), adult-onset spinocerebellar ataxia, and sensory nerve degeneration with dysarthria and ophthalmoparesis (SANDO)

Four New BL Lac Surveys: Sampling New Populations

The advent of large area deep radio and X-ray surveys is leading to the creation of many new BL Lac samples. In particular, the ROSAT All-Sky, Green Bank and FIRST surveys are proving to be rich sources of new BL Lacs. We will discuss the methods used in four independent BL Lac searches based on these surveys. Comparison of the broadband spectral energy distributions of these BL Lacs with those of previously known objects clearly points to the existence of a large previously unrecognized population of objects with characteristics intermediate between those exhibited by Low and High energy peaked BL Lacs.Comment: 4 pages, 3 postscript figures, To be published in the Proceedings of the conference "BL Lac Phenomenon" held in Turku, Finland, June 22-26, 199

The high-intensity hyperon beam at CERN

A high-intensity hyperon beam was constructed at CERN to deliver Sigma- to experiment WA89 at the Omega facility and operated from 1989 to 1994. The setup allowed rapid changeover between hyperon and conventional hadron beam configurations. The beam provided a Sigma-flux of 1.4 x 10^5 per burst at mean momenta between 330 and 345 Gev/c, produced by about 3 x 10^10 protons of 450 GeV/c . At the experiment target the beam had a Sigma-/pi- ratio close to 0.4 and a size of 1.6 x 3.7 cm^2. The beam particle trajectories and their momenta were measured with a scintillating fibre hodoscope in the beam channel and a silicon microstrip detector at the exit of the channel. A fast transition radiation detector was used to identify the pion component of the beam.Comment: 20 pages, 13 figures. Submitted to Nucl. Instr. Meth.

The Radio Quiescence of Active Galaxies with High Accretion Rates

We present 6 cm Very Large Array observations of the Greene & Ho (2004) sample of 19 low-mass active galaxies with high accretion rates. This is one of the only studies of a uniform sample of narrow-line Seyfert 1 (NLS1) galaxies with such high sensitivity and resolution. Although we detect only one source, the entire sample is very radio-quiet down to strong limits. GH10 was found to have a radio power of 8.5 x 10^21 W/Hz, and a ratio R = f(6 cm)/f(4400 A) of 2.8. The 3 sigma upper limits for the remaining nondetections correspond to radio powers from 3 x 10^20 to 8 x 10^21 W/Hz and 0.47 < R <9.9. Stacking all nondetections yields an even stronger upper limit of R < 0.27. An assessment of existing observations in the literature confirms our finding that NLS1s are consistently radio-quiet, with a radio-loud fraction of 0%-6%, which is significantly lower than the 10%-20% observed in the general quasar population. By analogy with stellar-mass black holes, we argue that AGNs undergo a state transition at L_bol/L_Edd~0.01. Below this value a radiatively inefficient accretion flow effectively drives an outflow, which disappears when the flow turns into an optically thick, geometrically thin disk, or a radiation pressure-dominated slim disk at still higher L_bol/L_Edd.Comment: To appear in ApJ; 8 pages, 3 figures; uses emulateapj5.st

Infrared spectroscopy of phytochrome and model pigments

Fourier-transform infrared difference spectra between the red-absorbing and far-red-absorbing forms of oat phytochrome have been measured in H2O and 2H2O. The difference spectra are compared with infrared spectra of model compounds, i.e. the (5Z,10Z,15Z)- and (5Z,10Z,15E)-isomers of 2,3,7,8,12,13,17,18-octaethyl-bilindion (Et8-bilindion), 2,3-dihydro-2,3,7,8,12,13,17,18-octaethyl-bilindion (H2Et8-bilindion), and protonated H2Et8-bilindion in various solvents. The spectra of the model compounds show that only for the protonated forms can clear differences between the two isomers be detected. Since considerable differences are present between the spectra of Et8-bilindion and H2Et8-bilindion, it is concluded that only the latter compound can serve as a model system of phytochrome. The 2H2O effect on the difference spectrum of phytochrome supports the view that the chromophore in red-absorbing phytochrome is protonated and suggests, in addition, that it is also protonated in far-red-absorbing phytochrome. The spectra show that protonated carboxyl groups are influenced. The small amplitudes in the difference spectra exclude major changes of protein secondary structure

Schneefernerhaus as a mountain research station for clouds and turbulence

Cloud measurements are usually carried out with airborne campaigns, which are expensive and are limited by temporal duration and weather conditions. Ground-based measurements at high-altitude research stations therefore play a complementary role in cloud study. Using the meteorological data (wind speed, direction, temperature, humidity, visibility, etc.) collected by the German Weather Service (DWD) from 2000 to 2012 and turbulence measurements recorded by multiple ultrasonic sensors (sampled at 10 Hz) in 2010, we show that the Umweltforschungsstation Schneefernerhaus (UFS) located just below the peak of Zugspitze in the German Alps, at a height of 2650 m, is a well-suited station for cloud–turbulence research. The wind at UFS is dominantly in the east–west direction and nearly horizontal. During the summertime (July and August) the UFS is immersed in warm clouds about 25 % of the time. The clouds are either from convection originating in the valley in the east, or associated with synoptic-scale weather systems typically advected from the west. Air turbulence, as measured from the second- and third-order velocity structure functions that exhibit well-developed inertial ranges, possesses Taylor microscale Reynolds numbers up to 104, with the most probable value at ~ 3000. In spite of the complex topography, the turbulence appears to be nearly as isotropic as many laboratory flows when evaluated on the "Lumley triangle"

Optical Properties of Radio-selected Narrow Line Seyfert 1 Galaxies

We present results from the analysis of the optical spectra of 47 radio-selected narrow-line Seyfert 1 galaxies (NLS1s). These objects are a subset of the First Bright Quasar Survey (FBQS) and were initially detected at 20 cm (flux density limit ~1 mJy) in the VLA FIRST Survey. We run Spearman rank correlation tests on several sets of parameters and conclude that, except for their radio properties, radio-selected NLS1 galaxies do not exhibit significant differences from traditional NLS1 galaxies. Our results are also in agreement with previous studies suggesting that NLS1 galaxies have small black hole masses that are accreting very close to the Eddington rate. We have found 16 new radio-loud NLS1 galaxies, which increases the number of known radio-loud NLS1 galaxies by a factor of ~5.Comment: 18 pages, 20 figures, Accepted for publication in Ap

The Jet of 3C 17 and the Use of Jet Curvature as a Diagnostic of the X-ray Emission Process

We report on the X-ray emission from the radio jet of 3C 17 from Chandra observations and compare the X-ray emission with radio maps from the VLA archive and with the optical-IR archival images from the Hubble Space Telescope. X-ray detections of two knots in the 3C 17 jet are found and both of these features have optical counterparts. We derive the spectral energy distribution for the knots in the jet and give source parameters required for the various X-ray emission models, finding that both IC/CMB and synchrotron are viable to explain the high energy emission. A curious optical feature (with no radio or X-ray counterparts) possibly associated with the 3C 17 jet is described. We also discuss the use of curved jets for the problem of identifying inverse Compton X-ray emission via scattering on CMB photons.Comment: 6 pages, 6 figure (3 in color), 4 tables, ApJ accepte