Electronic-photonic millimeter-wave sensing element based on monolithically integrated LNA and triple-cavity ring modulator

We demonstrate CMOS-integrated mm-wave-to-optical sensing elements comprising LNAs and triple-ring modulators that break the conversion-bandwidth tradeoff, showing a projected noise figure of 24 dB at 57 GHz (30 mW/element, -45dBm RF-input, 6dBm laser LO). The elements are tileable at small pitches, enabling photonic disaggregation of large-scale phased arrays.000000000000000000000000000000000000000000000000000000010759 - The Regents of the University of California (dba UniversityAccepted manuscrip

Fast-tuning adiabatic microrings for CROW filters and athermal WDM receivers in a 45 nm SOI CMOS process

Adiabatic microrings with opposing p/n contacts achieve full carrier sweepout in reverse bias and energy-efficient carrier injection in forward bias, exhibiting 200GHz/V peak shift in C-band for athermal tuning over a 220 GHz range.Accepted manuscrip

Toward quantum electronic-photonic systems-on-chip: a monolithic source of quantum-correlated photons with integrated frequency locking electronics and pump rejection

We demonstrate a CMOS electronic-photonic photon-pair source with integrated feedback-controlled frequency locking, >80 dB on-chip pump rejection, and signal/idler demultiplexing, achieving a CAR of ≃5 at ≃40 ccps pair rate.Accepted manuscrip

Monolithically integrated high-order vernier filters and tuning circuits for electronic-photonic quantum system-on-chip

We demonstrate a monolithically integrated 6th-order filter, with heater driver circuits implemented alongside photonics in a zero-change 45 nm CMOS platform, achieving 80 dB on-chip pump power suppression.Accepted manuscrip

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Analog Optical Links: Modeling and Implementation

As next generation wireless and sensing systems scale to massive array sizes, so too scales the cost and complexity of data transmission and aggregation across the array. Silicon photonic links offer promising solutions to meet the high bandwidth and energy efficiency requirements of these future systems. This work addresses three challenges facing input/output scaling in photonic links. First, a new photonic system design framework called Berkeley Photonics Generator (BPG) is presented. BPG is an open-sourced, modular, and easy-to-use framework for end-to-end photonic system design. BPG aims to create an agile, robust, and easily adoptable workflow with a rich set of reusable libraries to boost the photonic design ecosystem. The design philosophy, plugin-based architecture, and technology-agnostic design workflow are described, and several design results enabled by BPG are discussed. Next, a new framework for modeling crosstalk and insertion loss penalty in digital optical links is presented. This framework provides intuitive understanding for the receive-filter imposed limitations of channel densification in optical links. The major sources of signal impairment are identified as functions of technology parameters and system design choices, such as channel spacing. The framework is used to derive optimal filter design parameters, and the utility of higher order filters is considered. Finally, analog modulation in optical links is proposed as an alternative signaling modality for high-bandwidth links. The fundamental gain and noise performance are derived for a generic analog optical link, and the performance of a microring in GlobalFoundries 45CLO platform is validated for use as a WDM compatible analog optical modulator. A proof-of-concept microring-resonator-based analog WDM link system is designed for data remoting in magnetic resonance imaging (MRI), demonstrating an SFDR3 of 63 dBHz2/3

Lab-on-Chip for Everyone: Introducing an Electronic-Photonic Platform for Multiparametric Biosensing Using Standard CMOS Processes

The recent pandemic has shown that accurate and on-demand information on various infections requires highly versatile, Point-of-Care (PoC) platforms providing diagnostic and prognostic multiparametric information, personalized to each patient. Despite the significant progress made over the last years in various biosensing technologies, existing solutions fail to meet the power and area requirements needed for highly scalable and portable next-generation PoC devices. This work presents a solution based on a first of its kind fully integrated electronic-photonic platform in a zero-change high volume CMOS-SOI process, tailored towards molecular and ultrasound sensing applications. Leveraging co-integration of $10\mu \text{m}$ micro-ring resonators (MRRs) with on-chip electronics, we address the current needs of scalability, power and area by providing nanophotonic sensing and readout processing on a monolithic electronic-photonic system-on-chip (EPSoC). This work unlocks the door towards complete and self-contained Lab-on-Chip (LoC) systems, capable of providing multiparametric biosensing information

Monolithically integrated feedback control of photon-pair generation by a nonlinear microring cavity in 45 nm CMOS

We demonstrate integrated feedback control of C-band four-wave mixing in a silicon microring cavity in zero-change 45 nm CMOS based on carrier sweepout, operating in-situ in both the stimulated and spontaneous regimes.Accepted manuscrip