Upper Bounds on the Capacity of Binary Channels with Causal Adversaries

In this work we consider the communication of information in the presence of a causal adversarial jammer. In the setting under study, a sender wishes to communicate a message to a receiver by transmitting a codeword $(x_1,...,x_n)$ bit-by-bit over a communication channel. The sender and the receiver do not share common randomness. The adversarial jammer can view the transmitted bits $x_i$ one at a time, and can change up to a $p$-fraction of them. However, the decisions of the jammer must be made in a causal manner. Namely, for each bit $x_i$ the jammer's decision on whether to corrupt it or not must depend only on $x_j$ for $j \leq i$. This is in contrast to the "classical" adversarial jamming situations in which the jammer has no knowledge of $(x_1,...,x_n)$, or knows $(x_1,...,x_n)$ completely. In this work, we present upper bounds (that hold under both the average and maximal probability of error criteria) on the capacity which hold for both deterministic and stochastic encoding schemes.Comment: To appear in the IEEE Transactions on Information Theory; shortened version appeared at ISIT 201

The benefit of a 1-bit jump-start, and the necessity of stochastic encoding, in jamming channels

We consider the problem of communicating a message $m$ in the presence of a malicious jamming adversary (Calvin), who can erase an arbitrary set of up to $pn$ bits, out of $n$ transmitted bits $(x_1,\ldots,x_n)$. The capacity of such a channel when Calvin is exactly causal, i.e. Calvin's decision of whether or not to erase bit $x_i$ depends on his observations $(x_1,\ldots,x_i)$ was recently characterized to be $1-2p$. In this work we show two (perhaps) surprising phenomena. Firstly, we demonstrate via a novel code construction that if Calvin is delayed by even a single bit, i.e. Calvin's decision of whether or not to erase bit $x_i$ depends only on $(x_1,\ldots,x_{i-1})$ (and is independent of the "current bit" $x_i$) then the capacity increases to $1-p$ when the encoder is allowed to be stochastic. Secondly, we show via a novel jamming strategy for Calvin that, in the single-bit-delay setting, if the encoding is deterministic (i.e. the transmitted codeword is a deterministic function of the message $m$) then no rate asymptotically larger than $1-2p$ is possible with vanishing probability of error, hence stochastic encoding (using private randomness at the encoder) is essential to achieve the capacity of $1-p$ against a one-bit-delayed Calvin.Comment: 21 pages, 4 figures, extended draft of submission to ISIT 201

Application of the codon-shuffling method : Synthesis and selection of de novo proteins as antibacterials

Library-based methods of non-rational and part-rational designed de novo peptides are worthy beacons in the search for bioactive peptides and proteins of medicinal importance. In this report, we have used a recently developed directed evolution method called "codon shuffling" for the synthesis and selection of bioactive proteins. The selection of such proteins was based on the creation of an inducible library of "codon-shuffled" genes that are constructed from the ligation-based assembly of judiciously designed hexamer DNA duplexes called dicodons. Upon induction with isopropyl 1-thio-beta-D-galactopyranoside, some library members were found to express dicodon-incorporated proteins. Because of this, the host cells, in our case Escherichia coli, were unable to grow any further. The bactereostatic/lytic nature of the dicodon proteins was monitored by growth curves as well as by zone clearance studies. Transmission electron microscopy of the affected cells illustrated the extent of cell damage. The proteins themselves were overexpressed as fusion partners and subsequently purified to homogeneity. One such purified protein was found to strongly bind heparin, an indication that the interaction of the de novo proteins may be with the nucleic acids of the host cell, much like many of the naturally occurring antibacterial peptides, e.g. Buforin. Therefore, our approach may help in generating a multitude of finely tuned antibacterial proteins that can potentially be regarded as lead compounds once the method is extended to pathogenic hosts, such as Mycobacteria, for example

COLECCIÓN ANTONIO GONZÁLEZ. CRONISTA OFICIAL DE TELDE [Material gráfico]

Copia digital. Madrid : Ministerio de Educación, Cultura y Deporte. Subdirección General de Coordinación Bibliotecaria, 201

Case Report A Case of Cutaneous Plasmablastic Lymphoma in HIV/AIDS with Disseminated Cryptococcus

We present a case of a patient with HIV/AIDS who presented with a tender left lower extremity cutaneous mass over a site of previous cryptococcal infection and was found to have plasmablastic lymphoma (PBL). The incidence of PBL is estimated to account for less than 5% of all cases of non-Hodgkin lymphoma (NHL) in HIV-positive individuals. In fact, there were only two reports of extraoral PBL at the time of a 2003 review. PBL in HIV-positive individuals is an aggressive malignancy that tends to occur in middle-aged males with low CD4 counts, high viral loads, and chronic HIV infection. The definitive diagnosis can be made with biopsy which typically shows malignant lymphoid cells that stain positive for plasma cell markers and negative for B-cell markers. The most common treatment is chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens, but the overall survival rate is poor despite its relative responsiveness to chemotherapy. This case highlights the challenges that remain in improving clinical outcomes, the importance of antiretroviral therapy and HIV disease control, and a potential association between a chronic inflammatory state caused by disseminated Cryptococcus and tumorigenesis in individuals with PBL

Development of a water-based cooling system for the Muon Chamber detector system of the CBM experiment

A water-based cooling system is being investigated to meet the cooling requirement of the Gas Electron Multiplier (GEM) based Muon Chamber (MuCh) detector system of the Compressed Baryonic Matter (CBM) experiment at GSI, Germany. The system is based on circulating cold water through the channels inside an aluminium plate. The aluminium plate is attached to a GEM chamber. A feasibility study is conducted on one small and two real-size prototype cooling plates. A microcontroller based unit has been built and integrated into the system to achieve automatic control and monitoring of temperature on plate surface. The real-size prototypes have been used in a test beam experiment at the CERN SPS (Super Proton Synchrotron) with the lead beam on a lead target. A setup using three prototype modules has been prepared in the lab for testing in a simulated real life environment. This paper discusses the working principle, mechanical design, fabrication, and test results of the cooling prototypes in detail.Comment: 8 pages, 12 figures, 2 table

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe