Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin

Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines

In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities. One of the compounds 2f has shown good in vitro antimycobacterial activity. All the synthesized compounds have shown moderate to good antibacterial activity

Elucidation of photocatalysis, photoluminescence and antibacterial studies of ZnO thin films by spin coating method

The ZnO thin films have been prepared by spin coating followed by annealing at different temperatures like 300 °C, 350 °C, 400 °C, 450 °C, 500 °C & 550 °C and ZnO nanoparticles have been used for photocatalytic and antibacterial applications. The morphological investigation and phase analysis of synthesized thin films well characterized by X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Photoluminescence (PL), Transmission Electron Microscopy (TEM) and Raman studies. The luminescence peaks detected in the noticeable region between 350 nm to 550 nm for all synthesized nanosamples are associated to the existence of defects of oxygen sites. The luminescence emission bands are observed at 487 nm (blue emission), and 530 nm (green emission) at the RT. It is observed that there are no modification positions of PL peaks in all ZnO nanoparticles. In the current attempt, the synthesized ZnO particles have been used photocatalytic and antibacterial applications. The antibacterial activity of characterized samples was regulated using different concentrations of synthesized ZnO particles (100 μg/ml, 200 μg/ml, 300 μg/ml, 400 μg/ml, 500 μg/ml and 600 μg/ml) against gram positive and gram negative bacteria (S. pnemoniae, S. aureus, E. coli and E. hermannii) using agar well diffusion assay. The increase in concentration, decrease in zone of inhibition. The prepared ZnO morphologies showed photocatalytic activity under the sunlight enhancing the degradation rate of Rhodamine-B (RhB), which is one of the common water pollutant released by textile and paper industries

Synthesis and biological evaluation of a new series of benzothiazole-benzothiadiazine conjugates as antibacterial agents

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin