Correlation between hippocampal sulcus width and severity of obstructive sleep apnea syndrome

The aim of the present study was to evaluate the relationship between obstructive sleep apnea syndrome (OSAS) severity and the hippocampal sulcus width in a cohort of subjects with OSAS and controls. A total of 149 OSAS patients and 60 nonapneic controls were included in the study. Overnight polysomnograpy was performed in all patients. Hippocampal sulcus width of the patients was measured by a radiologist blinded to the diagnosis of the patients. Other variables noted for each patient were as follows: gender, age, body mass index, apnea hypopnea index, Epworth sleepiness scale, sleep efficacy, mean saturation, lowest O-2 saturation, longest apnea duration, neck circumference, waist circumference, hip circumference. A total of 149 OSAS patients were divided into three groups: mild OSAS (n = 54), moderate OSAS (n = 40), severe OSAS (n = 55) groups. The control group consisted of patients with AHI < 5 (n = 60). Hippocampal sulcus width was 1.6 +/- A 0.83 mm in the control group; while 1.9 +/- A 0.81 mm in mild OSAS, 2.1 +/- A 0.60 mm in moderate OSAS, and 2.9 +/- A 0.58 mm in severe OSAS groups (p < 0.001). Correlation analysis of variables revealed that apnea hypopnea index (rs = 0.483, p < 0.001) was positively correlated with hippocampal sulcus width. Our findings demonstrated that severity of OSAS might be associated with various pathologic mechanisms including increased hippocampal sulcus width

Changes in the obstructive sleep apnea symptoms in heart transplantation patients

3rd World Heart Failure Congress -- NOV 29-DEC 02, 2012 -- Istanbul, TURKEYWOS: 00031169820005

Obstructive sleep apnea syndrome and gastroesophageal reflux disease: the importance of obesity and gender

WOS: 000352909700022PubMed ID: 25173794It is claimed that gastroesophageal reflux disease (GERD) increases in patients with obstructive sleep apnea syndrome (OSAS). We aimed to evaluate the prevalence of GERD in patients with OSAS and primary snoring and identify OSAS-related risk factors associated with GERD. In this prospective, cross-sectional, multicenter study, in total 1,104 patients were recruited for polysomnography: 147 subjects were in non-OSAS (primary snoring) and 957 patients were in OSAS group. All patients completed a validated GERD questionnaire. Demographic, anthropometric characteristics, and medical history were recorded. The prevalence of GERD was similar in OSAS (38.9 %) and non-OSAS (32.0 %) groups (p = 0.064). There was no difference in terms of major gastroesophageal reflux (GER) symptoms (heartburn/acid regurgitation) between non-OSAS and mild, moderate, and severe OSAS groups. The prevalence of GERD was increased in female OSAS patients (46.6 %) compared to males (35.7 %) (p = 0.002). In OSAS patients with GERD, body mass index was greater (34.0 +/- 7.0 vs. 33.1 +/- 6.8, p = 0.049), waist (115.5 +/- 13.9 vs. 113.1 +/- 13.4, p = 0.007) and hip (117.9 +/- 13.7 vs. 114.2 +/- 12.8, p < 0.0001) circumferences were larger, and Epworth sleepiness scores were higher (10.3 +/- 6.0 vs. 8.8 +/- 5.6, p < 0.0001) than OSAS patients without GERD. Multivariate analysis showed that GERD was significantly associated with female gender, hip circumference, and daytime sleepiness. In this large cohort, the prevalence of GERD was significantly increased in those with primary snoring and OSAS compared to the general population, but severity of OSAS did not influence GERD prevalence. The present results suggest that OSAS was not likely a causative factor but female gender, obesity, and sleepiness were related with prevalence of GERD in OSAS patients

The effect of methyl palmitate on treatment of experimental asthma

Objective: To determine the effects of methyl palmitate on murine model of chronic asthma

MISTLETOE EXTRACT HELIXOR TREATMENT ATTENUATES ALLERGIC AIRWAY REMODELING IN A MOUSE MODEL OF ASTHMA

Background: Mistletoe extracts (Viscum album extracts. VAE), widely used in complementary and alternative cancer therapy, possess cytotoxic, as well as immunostimulatory and anti-inflammatory effects. We investigated anti-inflammatory effect of Mistletoe extract Helixor as a possible approach for preventing ovalbumin-induced airway remodeling in a mouse model of asthma